Bilateral Metabolic Cataracts in 10-yr-old boy with newly diagnosed Type 1 Diabetes Mellitus

Patel, Chetanbabu; Plummer-Smith, Laura; Ugrasbul, Figen

doi:10.1111/j.1399-5448.2008.00453.x

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Also ketoacidosis, through a further decrease in antioxidant availability for lens proteins (9), could become a triggering factor in the development of acute cataract in newly diagnosed IDDM children. IDDM patients may have a longer preclinical phase than that appreciated previously (11), but while the preclinical phase may be protracted, the interval between the development of glucose intolerance and the emergence of overt hyperglycemia is short.…”

Section: Discussionmentioning

confidence: 93%

“…However, aldose‐reductase‐mediated insult alone is not sufficient to explain the occurrence of lens opacities in IDDM children. In fact, hyperglycemia, together with elevated percentages of HbA1c, represents a common finding of childhood‐onset type 1 diabetes (10), whereas acute diabetic cataract has been reported only in a very small number of patients (2–12). Thus, mechanisms other than osmotic stress should be claimed to explain the development of IDDM‐related hyperacute cataract.…”

Section: Discussionmentioning

confidence: 99%

“…Cataract represents one of the most frequent eye complications that patients with type 1 diabetes develop many years after the onset of the disease (1). Contrarily, acute cataract seen in young diabetic patients at the onset of the disease occurs more rarely (2–12). However, the mechanism of type 1 diabetic cataract formation has not been completely clarified; in fact, not all children with diabetes mellitus (DM) develop cataracts nor, on the other hand, all reported childhood cataracts are attributable to diabetes.…”

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confidence: 99%

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Acute juvenile cataract in newly diagnosed type 1 diabetic patients: a description of six cases

et al. 2011

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Cataract represents one of the most frequent eye complications in type 1 and type 2 patients; contrarily, acute cataract in young diabetic patients occurs very rarely. The aim of this study was to describe six cases of acute cataract in adolescents at the onset of type 1 diabetes. Eight hundred and twenty-six patients with type 1 diabetes were retrospectively studied. A multivariate analysis was applied to verify the weight of the following laboratory findings taken on admission (independent variables): glycemia, glycated hemoglobin (HbA1c), pH, base excess (BE),and on the occurrence of cataract (dependent variable). Six patients (0.7%) presented with acute lens opacities. Cataract development was significantly correlated with HbA1c and glycemia. The relative risk increases about twice for each percentage point from 12.8 to 14.1% of HbA1c; glycemic blood levels represent a moderate risk factor for cataractogenesis. Ketoacidosis and BE were not significantly correlated.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Acute juvenile cataract in newly diagnosed type 1 diabetic patients: a description of six cases

et al. 2011

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“…Early cataract was described as a rare ocular complication in pediatric patients at diabetes onset by a series of case reports and single center studies 11–18 . Simunovic et al reviewed the literature and found 16 publications describing 74 pediatric patients with cataract.…”

Section: Introductionmentioning

confidence: 99%

Cataract in children and adolescents with type 1 diabetes. Insights from the German/Austrian DPV registry

et al. 2022

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Objective: To study diabetic cataract in type 1 diabetes in a large pediatric cohort. Methods:The 92,633 patients aged 0.5-21 years from German/Austrian multicenter diabetes registry (DPV) were analyzed. The 235 patients (0.25%) with diabetic cataract were found, 200 could be categorized: 67 with early cataract (3 months before diabetes onset -12 months afterwards), 133 with late cataract (>12 months after diabetes onset). Regression models adjusted for age and gender were used to compare clinical parameters at diabetes onset. Regression models for patients with late cataract were implemented for the total documentation period and additionally adjusted for diabetes duration.Results: Rate of cataract development shows a peak at diabetes onset and declines with longer diabetes duration. Patients with cataract showed strong female preponderance. Patients developing early cataract were older at diabetes onset (12.8 years [11.8/13.9] vs. 8.9 [8.9/9.0]; p < 0.001) and showed higher HbA1c than patients without cataract (9.

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Current literature in diabetes

2009

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Bilateral Metabolic Cataracts in 10-yr-old boy with newly diagnosed Type 1 Diabetes Mellitus

Cited by 7 publications

References 11 publications

Acute juvenile cataract in newly diagnosed type 1 diabetic patients: a description of six cases

Acute juvenile cataract in newly diagnosed type 1 diabetic patients: a description of six cases

Cataract in children and adolescents with type 1 diabetes. Insights from the German/Austrian DPV registry

Current literature in diabetes

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