Bilateral Mesenchymal Hamartoma of the Chest Wall in a 3-Month-Old Boy: A Case Report and Review of the Literature

Alfaraidi, Mona; Alaradati, Hossam; Mamoun, Irfan; Mohammed, Shamayel

doi:10.1155/2017/2876342

Cited by 6 publications

(26 citation statements)

References 12 publications

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“…According to the literatures, there are two main treatment approaches for MHCW. For the patients of unilateral and larger volume of MHCW, with clinical respiratory symptoms, the surgical resection is a very suitable treatment [4] . For the smaller asymptomatic patients, the conservative management with imaging modality is recommended [17] .…”

Section: Discussionmentioning

confidence: 99%

“…Mesenchymal hamartoma of the chest wall(MHCW), also known as chondromesenchymal hamartoma, is a rare benign extrapleural lesion that arises from rib [1] . It has an incidence of about 0.03% among primary bone tumors [2,3] , and mostly occurs in fetal life, neonates or early infancy [4] . Multifocal or/and bilateral lesions are extremely rare.…”

Section: Introductionmentioning

confidence: 99%

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Congenital Bilateral and Multifocal Mesenchymal hamartoma of the chest wall: A Case in a Neonate and Differential Diagnosis

Zhang

et al. 2021

Preprint

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Background:Mesenchymal hamartoma of the chest wall(MHCW) is a rare benign extrapleural lesion that arises from rib or spine of neonates or early infancy, and commonly presents as a unilateral mass. Here, we describe a rare case of bilateral and multifocal MHCW in the right 5th rib and the left 11-12th thoracic and 1st lumbar vertebrae.Case presentation:A male neonate of 3700g weight transferred to our hospital with mild respiratory distress and an asymptomatic, progressively enlarging intra-thoracic mass. Computed tomography scan(CT) and magnetic resonance imaging(MRI) indicated a large well-circumscribed, heterogeneous enhancing mass, arising from the posterior-medial aspect of the right chest wall, involving 3-5th posterior ribs. Other smaller sizes lesions observed in vertebral arch and transverse process of the left 11-12th thoracic and 1st lumbar vertebrae. The thoracotomy with en bloc resection of the mass and the 5th rib was performed. Microscopically, the lesion was cystic and solid, consisted of hyaline cartilages, mesenchymal cells, and various-sized hemorrhagic spaces. Immunohistochemically, the cartilages and mesenchymal cells were positive for S-100, Smooth Muscle Actin(SMA), CD163 and CD68. The epithelium cells of aneurysmal bone cyst(ABC)-like were negative for CD34. Ki-67 estimated at 5%-10%. Fluorescence in situ hybridization(FISH) was negative for USP6 gene break-apart probe, which ruled out primary ABC. At 8-month follow-up postoperatively, the right chest walls with no sign of recurrence and the lesions of left vertebral arch and transverse process were stable, no increased in size.Conclusion:The bilateral and multifocal MHCW is considerably rare and related clinical research is limited. Fortunately, we clearly observed the tumor’s origin, growth process from the earlier pregnancy to delivery, different effects during the fetal periods, and differential diagnosis. This report may raise awareness regarding the MHCW.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Congenital Bilateral and Multifocal Mesenchymal hamartoma of the chest wall: A Case in a Neonate and Differential Diagnosis

Zhang

et al. 2021

Preprint

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“…A subclinical presentation of mesenchymal hamartoma of the chest wall may also occur, as in the present case, in which the finding was incidental. Due to the non-specific clinical presentation, the radiological appearance and the histological features seen on small needle biopsies may be suspicious for infection or malignancy [5–7].…”

Section: Discussionmentioning

confidence: 99%

“…The accuracy of early diagnosis of benign mesenchymal hamartoma of the chest wall is important, as in cases where chemotherapy has been initiated for the treatment of a presumed diagnosis of embryonal sarcoma, chemotherapy has been reported to result in patient mortality [11,12]. The treatment of mesenchymal hamartoma in symptomatic patients is surgical resection, which results in favorable prognosis [5]. Previous cases reports of spontaneous regression raise the possibility of a conservative treatment approach especially for smaller asymptomatic cases of mesenchymal hamartoma of the chest wall [13,14].…”

Section: Discussionmentioning

confidence: 99%

A Case of Mesenchymal Hamartoma of the Chest Wall in a 4-Month-Old Infant

et al. 2019

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Patient: Male, 4-months Final Diagnosis: Mesenchymal hamartoma Symptoms: Asymptomatic chest wall mass Medication: — Clinical Procedure: — Specialty: Radiology Objective: Rare disease Background: Mesenchymal hamartoma of the chest wall is a rare benign lesion that typically presents in early infancy. However, the clinical presentation can be atypical, with imaging features that mimic infection or malignancy. Imaging combined with histopathology is essential in the diagnosis. A case of mesenchymal hamartoma of the chest wall in a 4-month-old infant is presented. Case Report: A 4-month-old infant had an incidental finding of a large right-sided chest wall mass. Initial imaging included thoracoabdominal ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). Histology of an initial open biopsy was inconclusive. The diagnosis of mesenchymal hamartoma was confirmed by histology of the resection specimen, which showed a benign, mixed, chondroid, mesenchymal, and cystic hamartoma with areas of calcification and ossification. Conclusions: This case showed that the diagnosis of mesenchymal hamartoma of the chest wall, which is characterized by heterogeneous components, may require a combined approach for the diagnosis that includes imaging and histology. Increased clinical awareness of mesenchymal hamartoma in infants may help to guide the approach to the correct diagnosis and prevent unnecessarily radical treatment for this benign condition.

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“…Mesenchymal hamartoma of the chest wall (MHCW) is a tumor that arises from one or more ribs [1] , which typically appears during the neonatal period and in childhood [2] . MHCW generally presents as unilateral and solitary, but multiple or bilateral MHCW have been reported [3] .…”

Section: Introductionmentioning

confidence: 99%

A case of mesenchymal hamartoma of the chest wall of a child

Trung

Duc

Ngoc³

et al. 2021

Radiology Case Reports

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Mesenchymal hamartoma of the chest wall is a rare benign tumor that usually occurs in infants and children. The clinical presentations and imaging features are atypical and difficult to differentiate from malignant tumors. In this article, we present a case with a large mesenchymal hamartoma tumor of the chest wall. A large right-sided chest wall mass was discovered in a 6-month-old boy by his mother. Chest X-ray revealed a thoracic mass with well-defined margins on the right side that expanded into the right ribs. Chest computed tomography showed that the mass originated from the thoracic wall. The patient underwent complete removal of the mass, and histopathology results confirmed a mesenchymal hamartoma.

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Bilateral Mesenchymal Hamartoma of the Chest Wall in a 3-Month-Old Boy: A Case Report and Review of the Literature

Cited by 6 publications

References 12 publications

Congenital Bilateral and Multifocal Mesenchymal hamartoma of the chest wall: A Case in a Neonate and Differential Diagnosis

Congenital Bilateral and Multifocal Mesenchymal hamartoma of the chest wall: A Case in a Neonate and Differential Diagnosis

A Case of Mesenchymal Hamartoma of the Chest Wall in a 4-Month-Old Infant

A case of mesenchymal hamartoma of the chest wall of a child

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