Bilateral Massive Retinal Gliosis Associated With Retinopathy of Prematurity

Houston, Samuel K.; Bourne, T. David; Lopes, M. Beatriz S.; Ghazi, Nicola G.

doi:10.5858/133.8.1242

Cited by 19 publications

(7 citation statements)

References 12 publications

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“…MRG represents a benign, intraocular, reactive proliferation of glial tissue occurring in response to variable insults. The reported inciting factors include chronic inflammation, trauma, vascular abnormalities, glaucoma, and retinal diseases such as long-standing retinal detachment and retinopathy of prematurity [4,5]. In our case, the presentation was late in onset and no triggering events were found.…”

Section: Discussionmentioning

confidence: 58%

Massive Retinal Gliosis in Microphthalmic Globe With Cyst Masquerading as a Neoplasm

Goel¹,

Raghav²,

Agarwal³

et al. 2021

Cureus

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We report a rare case of a bilaterally blind, 33-year-old male, who presented with rapidly progressive, painless swelling in the right orbit for two months, in the absence of ocular trauma. Suspecting an intraocular neoplasm, a contrast-enhanced MRI (CE-MRI) orbit was performed, which was suggestive of a right-sided superomedial eccentric soft-tissue lesion with bilateral rudimentary globes associated with cyst, hypoplastic optic nerves, and focal areas of calcification. Diffusion-weighted MRI demonstrated diffusion restriction and yielded an indeterminate value of apparent diffusion coefficient (ADC). A right enucleation with excision of the cyst was performed. Histopathological examination confirmed the diagnosis of a rightsided massive retinal gliosis (MRG) with bilateral microphthalmia with cyst. This case demonstrates the role of a detailed histopathological analysis along with immunohistochemistry (IHC) in differentiating MRG from a neoplasm.

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Section: Discussionmentioning

confidence: 58%

Massive Retinal Gliosis in Microphthalmic Globe With Cyst Masquerading as a Neoplasm

Goel¹,

Raghav²,

Agarwal³

et al. 2021

Cureus

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“…In humans, massive retinal gliosis is a rare, benign, intraocular condition that develops in association with other ocular diseases and is mainly constituted by Müller cell activation [ 150 ]. There are only a couple, not very recent, case reports describing the association between massive retinal gliosis and ROP [ 151 , 152 ]. One of them reported the presence of bilateral massive gliosis in a 39-year-old man born prematurely that developed severe ROP with retinal detachment [ 151 ], suggesting that severe ROP may have deleterious effects during the patient life.…”

Section: The Impact Of Rop In the Central Nervous Systemmentioning

confidence: 99%

“…There are only a couple, not very recent, case reports describing the association between massive retinal gliosis and ROP [ 151 , 152 ]. One of them reported the presence of bilateral massive gliosis in a 39-year-old man born prematurely that developed severe ROP with retinal detachment [ 151 ], suggesting that severe ROP may have deleterious effects during the patient life. Although no clinical evidence indicates that gliosis may participate in ROP pathogenesis, results in preclinical models suggest this possibility.…”

Section: The Impact Of Rop In the Central Nervous Systemmentioning

confidence: 99%

Neurosensory Alterations in Retinopathy of Prematurity: A Window to Neurological Impairments Associated to Preterm Birth

et al. 2022

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Retinopathy of prematurity (ROP) is one of the main blinding diseases affecting preterm newborns and is classically considered a vascular disorder. The premature exposure to the extrauterine environment, which is hyperoxic in respect to the intrauterine environment, triggers a cascade of events leading to retinal ischemia which, in turn, makes the retina hypoxic thus setting off angiogenic processes. However, many children with a history of ROP show persistent vision impairment, and there is evidence of an association between ROP and neurosensory disabilities. This is not surprising given the strict relationship between neuronal function and an adequate blood supply. In the present work, we revised literature data evidencing to what extent ROP can be considered a neurodegenerative disease, also taking advantage from data obtained in preclinical models of ROP. The involvement of different retinal cell populations in triggering the neuronal damage in ROP was described along with the neurological outcomes associated to ROP. The situation of ROP in Italy was assessed as well.

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“…Massive retinal gliosis (MRG) is a rare, benign intraocular condition that may develop in association with longstanding eye conditions, including chronic inflammation, vascular disorders, glaucoma, trauma, prematurity retinopathy, surgery, and congenital abnormalities (microphthalmos and cyst). [1][2][3][4][5] It may represent a non-neoplastic reactive tissue response to retinal injury. 6 We describe an unusual case of MRG-like, which occurred 20 years after evisceration.…”

mentioning

confidence: 99%

“…The differential diagnosis of such an intraocular lesion includes uveal melanoma, astrocytic hamartoma, retinal hemangioblastomas, tumours of the retinal pigment epithelium, metastasis, schwannoma of ciliary nerves, and vasoproliferative tumours of the retina. [1][2][3][4][5]8,9 This case is differentiated from these alternative diagnoses based on patient history and previous clinical examinations data and on the histopathological features and immunohistochemistry of the lesions.…”

mentioning

confidence: 99%