Bilateral malignant cystosarcoma phyllodes

Notley, R. G.; Griffiths, H. J. L.

doi:10.1002/bjs.1800520511

Cited by 15 publications

(7 citation statements)

References 7 publications

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“…In 1958, Reich and Solomon (Reich and Solomon, 1958) reported the first case of bilateral histologically malignant cystosarcoma phyllodes with metastasis. A subsequent similar case has been reported by Notley and Griffiths (Notley and Griffiths, 1965).…”

Section: Introductionsupporting

confidence: 64%

“…The exact pathogenesis of the development of cystosarcoma is an enigma, but many of the tumors are thought to arise from pre-existing fibroadenomas (Cooper and Ackerman, 1943;Dyer et al, 1966;Hill and Stout, 1942;Lee and Pack, 1931;Notley and Griffiths, 1965). Patients have noted small lumps in their breasts for as many as 45 years before the nodule began to grow and the diagnosis of cystosarcoma phyllodes was made (Maier et al, 1968).…”

Section: Etiologymentioning

confidence: 99%

“…Eight percent (Adair and Henmann, 1946) to 38.9% (Obermaql965) of the lesions have been reported histologically malignant. The series of Lee and Pack (Lee and Pack, 1931) (one malignant case in 11 1 tumors) is usually disregarded when calculating incidences as it contains an exceptionally small percentage of malignant cases compared to other large series (Ariel, 1961;Notley and Griffiths, 1965). The accepted incidence of histologically malignant tumors appears to be 23%-27% of all cases (Notley and Griffiths, 1965;Treves and Sunderland, 1951).…”

Section: Incidencementioning

confidence: 99%

See 2 more Smart Citations

Metastatic cystosarcoma phyllodes: A case report and review of the literature

Kessinger¹,

Foley²,

Lemon³

et al. 1972

Journal of Surgical Oncology

149

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The breast tumor cystosarcoma phyllodes probably does not Rpresent an entity, but rather a spectrum of disease including a benign form, a histologically malignant form, and a metastatic form. In an attempt to better understand the metastatic variant, all 66 cases which could be found in the english literature and an additional case from this institution were reviewed.The tumor often arises from a fibroadenoma, but its etiology is uncertain. Factors that determine the benignity or malignancy of the tumor are unknown, but a lower fertility rate in patients with metastases warrants interest.Incidence is low; cystosarcoma makes up about 0.5% of alI breast tumors and only 3-12% of these are metastatic.The tumor presents as a breast mass, often of large size, but there is no clinical feature peculiar to the metastatic variant.Gross and microscopic pathologic findings cannot accurately forecast the metastatic potential of the tumor, but are of more predictive value than the clinical presentation. The clinical course is the only sure means of determining metastatic potential at present.

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Section: Introductionsupporting

confidence: 64%

Section: Etiologymentioning

confidence: 99%

Section: Incidencementioning

confidence: 99%

See 1 more Smart Citation

Metastatic cystosarcoma phyllodes: A case report and review of the literature

Kessinger¹,

Foley²,

Lemon³

et al. 1972

Journal of Surgical Oncology

149

View full text Add to dashboard Cite

show abstract

“…11) and 3 months later a sarcoma appeared in the right breast. This case has been previously reported (Notley and Griffiths 1965). Case 5 died of congestive cardiac failure two years after mastectomy with no clinical evidence of local recurrence or metastasis, but there was no necropsy.…”

Section: Follow-up Detailsmentioning

confidence: 64%

Sarcoma of breast.

Fawcett¹

1967

Br J Cancer

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“…The first report of malignant cystosarcoma phyllodes bilaterally was by Reich and Solomon in 1958 in which both breasts became involved in association with pregnancy [24]. Bader and Isaacson in 1961 reported another case with the apparent stimulus of pregnancy [2] and in 1965 Motley and G riffiths reported the third case of bilateral malignant cystosar coma phyllodes [17]. This was in a post-menopausal woman who died within 9 months of her disease.…”

Section: Literature Reviewmentioning

confidence: 94%