Bilateral high-frequency electrical impulses to the thalamus reduce voice tremor: acoustic and electroglottographic analysis. A case report

Moringlane, J. R.; Pützer, Manfred; Barry, William J.

doi:10.1007/s00405-003-0684-x

Cited by 19 publications

(15 citation statements)

References 15 publications

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“…31 The importance of these parameters in the differentiation of voice production patterns has been documented in a number of recent studies. 12,14,18,25,26,31,32 The phonatory and articulatory behavior of the patients was analyzed at group and at individual level with and without stimulation. The patients' group and individual behavior was also compared with normal speakers' articulation and phonatory behavior (10 male and 10 female speakers).…”

Section: Measures and Experimental Proceduresmentioning

confidence: 99%

“…[8][9][10][11][12][13][14][15] But, the effect of DBS on all the components of speech production at the same time has rarely been investigated. 16 The purpose of this study is to investigate the two speech subsystems (the phonation system and the glottal-supraglottal articulation system) using synchronically registered speech material, which allows us to analyze glottal-supraglottal articulation and phonation behavior together.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Effect of Deep Brain Stimulation on Different Speech Subsystems in Patients with Multiple Sclerosis

Pützer¹,

Barry²,

Moringlane³

2007

Journal of Voice

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Section: Measures and Experimental Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Effect of Deep Brain Stimulation on Different Speech Subsystems in Patients with Multiple Sclerosis

Pützer¹,

Barry²,

Moringlane³

2007

Journal of Voice

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“…34,35 However, the paucity of literature associated with DBS and vocal tremor may reflect the primary goal of this management approach; to regain mobility or improved control of limbs and hands.…”

Section: Introductionmentioning

confidence: 97%

Perception of Vocal Tremor During Sustained Phonation Compared With Sentence Context

2012

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“…Our findings suggest that the optimal target for VT might be a slightly different than the target for limb tremor [48]. Future studies may obtain even better VT control with unilateral stimulation of the most ventral and medial part of the “dominant” Vim nucleus [27, 42]. This is in contrast to stimulation-induced dysarthria which is caused by the electrodes placed more laterally and is more common following bilateral than unilateral stimulation [28, 49, 50].…”

Section: Discussionmentioning

confidence: 99%

Unilateral Thalamic Deep Brain Stimulation for Voice Tremor

Avecillas-Chasín

Poologaindran

Morrison

et al. 2018

Stereotact Funct Neurosurg

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Background: Voice tremor (VT) is the involuntary and rhythmical phonatory instability of the voice. Recent findings suggest that unilateral deep brain stimulation of the ventral intermediate nucleus (Vim-DBS) can sometimes be effective for VT. In this exploratory analysis, we investigated the effect of Vim-DBS on VT and tested the hypothesis that unilateral thalamic stimulation is effective for patients with VT. Methods: Seven patients with VT and previously implanted bilateral Vim-DBS were enrolled in the study. Each patient was randomized and recorded performing sustained phonation during the following conditions: left thalamic stimulation, right thalamic stimulation, bilateral thalamic stimulation (Bil-ON), and no stimulation (Bil-OFF). Perceptual VT ratings and an acoustic analysis to find the rate of variation of the fundamental frequency measured by the standard deviation of the pitch (f0SD) were performed in a blinded manner. For the purposes of this study, a “dominant” side was defined as one with more than twice as much reduction in VT following Vim-DBS compared to the contralateral side. The Wilcoxon signed-rank test was performed to compare the effect of the dominant side stimulation in the reduction of VT scores and f0SD. The volume of activated tissue (VAT) of the dominant stimulation side was modelled against the degree of improvement in VT to correlate the significant stimulation cluster with thalamic anatomy. Finally, tractography analysis was performed to analyze the connectivity of the significant stimulation cluster. Results: Unilateral stimulation was beneficial in all 7 patients. Five patients clearly had a “dominant” side with either benefit only seen following stimulation of one side or more than twice as much benefit from one side compared to the other. Two patients had similar benefit with unilateral stimulation from either side. The Wilcoxon paired test showed significant differences between unilateral dominant and unilateral nondominant stimulation for VT scores (p = 0.04), between unilateral dominant and Bil-OFF (p = 0.04), and between Bil-ON and unilateral nondominant stimulation (p = 0.04). No significant differences were found between Bil-ON and unilateral dominant condition (p = 0.27), or between Bil-OFF and unilateral nondominant (p = 0.23). The dominant VAT showed that the significant voxels associated with the best VT control were located in the most ventral and medial part of the Vim nucleus and the ventralis caudalis anterior internus nucleus. The connectivity analysis showed significant connectivity with the cortical areas of the speech circuit. Conclusions: Unilateral dominant-side thalamic stimulation and bilateral thalamic stimulation were equally effective in reducing VT. Nondominant unilateral stimulation alone did not significantly improve VT.

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Bilateral high-frequency electrical impulses to the thalamus reduce voice tremor: acoustic and electroglottographic analysis. A case report

Cited by 19 publications

References 15 publications

Effect of Deep Brain Stimulation on Different Speech Subsystems in Patients with Multiple Sclerosis

Effect of Deep Brain Stimulation on Different Speech Subsystems in Patients with Multiple Sclerosis

Perception of Vocal Tremor During Sustained Phonation Compared With Sentence Context

Unilateral Thalamic Deep Brain Stimulation for Voice Tremor

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