Bilateral Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Breast: A Very Rare Entity and Review of the Literature

Majid, Noura; Amrani, M.; Ghissassi, Ibrahim El; Cadi, Mina Ait El; Bouzidi, M. El; Kabous, M. El; Kherbach, Aicha; Errihani, Hassan

doi:10.1155/2013/964568

Cited by 6 publications

(8 citation statements)

References 16 publications

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“…pPNET often occur in the thoracopulmonary region (Askin tumor), retroperitonium, and extremities [ 11 ]. Uncommon locations include the thyroid [ 12 ], kidney [ 13 ], breast [ 14 ], nose [ 15 ], adrenal gland [ 16 ], prostate [ 17 ], head and neck [ 18 ], abdomen, pelvic soft tissues [ 9 ], and bone [ 19 ]. Our patients had tumors in bone ( n = 19: limbs 11, vertebrae 4, craniofacial skeleton 4), soft tissue ( n = 10: pelvis 2, retroperitoneum 2, groin 1, nasopharynx 1, chest wall 2, mediastinum 2), and organs ( n = 7: parotid 1, pulmonary 4, spleen 1, liver 1).…”

Section: Discussionmentioning

confidence: 99%

Peripheral primitive neuroectodermal tumor: Dynamic CT, MRI and clinicopathological characteristics - analysis of 36 cases and review of the literature

Tan

Zhang

et al. 2014

Oncotarget

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BackgroundThe peripheral primitive neuroectodermal tumor (pPNET) is a rare malignant tumor originating from neuroectoderm. The accurate diagnosis is essential for the treatment of pPNET.Methodswe performed the largest cases of retrospective analysis thus far to review the unique computed tomography (CT), magnetic resonance imaging (MRI), and clinicopathological features of pPNET. The tumor location, morphological features, signal intensity, contrast enhancement characteristics, and involvement of local soft tissues of 36 pPNETs were assessed.ResultsOur results showed that there were more men (25/36) than women pPNETs patients. Unenhanced MRI (16 cases) showed that 14 cases were isointense and 2 cases were hypointense on T1WI. Nine cases were isointense and 7 were hyperintense on T2WI. Most pPNETs had heterogeneous signal intensity with small necrosis (CT: 31/36; MRI: 14/16) as well as heterogeneous enhancement (CT: 34/30; MRI: 15/16). The tumors usually had ill-defined borders and irregular shapes (CT: 30/36; MRI: 15/16). Pathologic exam showed small areas of necrosis in all tumors.ConclusionsThe diagnosis of pPNET should be suggested in young men when the imaging depicts a single large ill-defined solid mass with small area of necrosis, especially for those whose images show iso-intense on T1WI and T2WI and have heterogeneous enhancement.

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Section: Discussionmentioning

confidence: 99%

Peripheral primitive neuroectodermal tumor: Dynamic CT, MRI and clinicopathological characteristics - analysis of 36 cases and review of the literature

Tan

Zhang

et al. 2014

Oncotarget

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“…The thoracopulmonary region (Askin tumor) is the single most common primary site. PNET in the breast is extremely rare and has been reported only nine times earlier in the world literature [2][3][4][5][6][7][8][9][10]. This is the third case being reported from India.…”

Section: Discussionmentioning

confidence: 99%

Primitive Neuroectodermal Tumour of Breast—A Case Report

Mahajan

Raju

Rehmani

et al. 2014

Indian J Surg Oncol

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“…Further ESFTs in bladder and prostate noted in this cohort were rarely reported. [42][43][44][45][46][47] Metastatic disease involving lung, lymph nodes, and several organs has been described 12,48,49 ; however, primary ESFTs of breast, [50][51][52] lung, [53][54][55] intestine, 56,57 and brain 22,[58][59][60][61][62] were rarely reported.…”

Section: Clinical Pathologymentioning

confidence: 99%

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Murthy

Challa

Raju

et al. 2020

Clin Med�Insights�Pathol

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Introduction: The diagnosis of Ewing sarcoma family of tumours (ESFT) is challenging, especially in adults and in extra-skeletal or visceral location. Several morphologic mimics with varied treatment options and prognosis confer diagnostic dilemmas. Application of ancillary diagnostic modalities in surgical pathology in clinical routine has enabled accurate diagnosis of ESFT in bone, soft tissues, and viscera. Aim: The study aims to assess the clinicopathological features including molecular test results of ESFT with emphasis on sex, age, and location, especially extra-skeletal soft tissue and visceral location. Material and Methods: Data of clinicopathological, molecular tests (wherever performed), diagnosis rendered in 302 ESFT over a decade from our centre were reviewed. Statistical comparison of skeletal and extra-skeletal tumours with reference to age and sex was done using SPSS package. The P value of <.05 was considered significant. Results: The cohort included 302 ESFTs with 49% skeletal and 51% extra-skeletal tumours. Thigh was most common site among skeletal tumours; chest wall, paraspinal location, and retroperitoneum among soft tissues (39.4%); and kidney, ovary, and cervix among visceral tumours (11.3%). Fluorescence in situ hybridisation for EWSR1 gene rearrangement was positive in 54 patients and reverse-transcriptase polymerase chain reaction in 19 patients. Predominance of male sex, younger age and location in extremities among skeletal tumours and lack of gender predilection, higher age and axial location in extra-skeletal tumours were noted, which were statistically significant. Molecular tests were performed more frequently in extra-skeletal tumours, especially in visceral tumours to establish the diagnosis. Conclusions: The study showed statistically significant differences in the age, sex, and location between skeletal and extra-skeletal ESFT. The increased percentage of extra-skeletal tumours especially in viscera was attributed to the increased awareness and availability of ancillary techniques.

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Bilateral Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Breast: A Very Rare Entity and Review of the Literature

Cited by 6 publications

References 16 publications

Peripheral primitive neuroectodermal tumor: Dynamic CT, MRI and clinicopathological characteristics - analysis of 36 cases and review of the literature

Peripheral primitive neuroectodermal tumor: Dynamic CT, MRI and clinicopathological characteristics - analysis of 36 cases and review of the literature

Primitive Neuroectodermal Tumour of Breast—A Case Report

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

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