Bilateral endogenous Scedosporium prolificans endophthalmitis after lung transplantation

Vagefi, M. Reza; Kim, Eleanore T; Alvarado, Richard G.; Duncan, Jacque L.; Howes, Ed L.; Crawford, J. Brooks

doi:10.1016/j.ajo.2004.08.005

Cited by 57 publications

(32 citation statements)

References 4 publications

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“…[1][2][3] This may have a significant impact on successful treatment because of the inherent resistance of some Scedosporium species to amphotericin, an agent often employed to treat Aspergillus species infection. Direct PCR followed by DNA sequencing for fungi was performed in the second case.…”

Section: Discussionmentioning

confidence: 99%

“…Scedosporium sp usually enter via the respiratory tract or the skin after trauma. Invasive and airway disease has been described in several lung transplant recipients, [1][2][3][4] as well as in other solid-organ and bone marrow transplant recipients. 5,6 Mortality from disseminated S apiospermum infection has been reported to be as high as 61% despite anti-fungal therapy, 5 and may be as high as 100% in lung transplantation.…”

mentioning

confidence: 99%

“…5,6 Mortality from disseminated S apiospermum infection has been reported to be as high as 61% despite anti-fungal therapy, 5 and may be as high as 100% in lung transplantation. [1][2][3] Because Scedosporium sp resemble Aspergillus sp morphologically, empirical therapy targeted at Aspergillus sp to which Scedosporium sp are often resistant may contribute to this high mortality. Therefore, earlier diagnosis and targeted therapy are likely to be important in reducing mortality from invasive disease.…”

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confidence: 99%

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Successful Treatment of Disseminated Scedosporium Infection in 2 Lung Transplant Recipients: Review of the Literature and Recommendations for Management

Musk

Chambers

Chin

et al. 2006

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Successful Treatment of Disseminated Scedosporium Infection in 2 Lung Transplant Recipients: Review of the Literature and Recommendations for Management

Musk

Chambers

Chin

et al. 2006

The Journal of Heart and Lung Transplantation

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“…This type of endophthalmitis is more common among immunocompromised hosts, patients receiving chemotherapy or total parenteral nutrition, and i.v. drug users (67,130,133,259,283,335,451,482). P. boydii has been identified as the etiologic agent in a case of endogenous endophthalmitis from an infected porcine allograft of the aortic valve (417) and even in a patient without recognizable risk factors (324).…”

Section: Ii) Extrapulmonary Infections (A) Cutaneous and Subcutaneoumentioning

confidence: 99%

Infections Caused byScedosporiumspp

et al. 2008

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SUMMARY Scedosporium spp. are increasingly recognized as causes of resistant life-threatening infections in immunocompromised patients. Scedosporium spp. also cause a wide spectrum of conditions, including mycetoma, saprobic involvement and colonization of the airways, sinopulmonary infections, extrapulmonary localized infections, and disseminated infections. Invasive scedosporium infections are also associated with central nervous infection following near-drowning accidents. The most common sites of infection are the lungs, sinuses, bones, joints, eyes, and brain. Scedosporium apiospermum and Scedosporium prolificans are the two principal medically important species of this genus. Pseudallescheria boydii, the teleomorph of S. apiospermum, is recognized by the presence of cleistothecia. Recent advances in molecular taxonomy have advanced the understanding of the genus Scedosporium and have demonstrated a wider range of species than heretofore recognized. Studies of the pathogenesis of and immune response to Scedosporium spp. underscore the importance of innate host defenses in protection against these organisms. Microbiological diagnosis of Scedosporium spp. currently depends upon culture and morphological characterization. Molecular tools for clinical microbiological detection of Scedosporium spp. are currently investigational. Infections caused by S. apiospermum and P. boydii in patients and animals may respond to antifungal triazoles. By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans.

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“…Accumulating clinical experience suggests that it may be the preferred antifungal option. 16 The only 2 survivors in these series were treated with this agent. Posaconazole has in vitro activity similar to that of voriconazole.…”

Section: Discussionmentioning

confidence: 99%

Implantable cardioverter-defibrillator infection due to Scedosporium apiospermum

Sarvat

Sarria

2007

Journal of Infection

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Bilateral endogenous Scedosporium prolificans endophthalmitis after lung transplantation

Cited by 57 publications

References 4 publications

Successful Treatment of Disseminated Scedosporium Infection in 2 Lung Transplant Recipients: Review of the Literature and Recommendations for Management

Successful Treatment of Disseminated Scedosporium Infection in 2 Lung Transplant Recipients: Review of the Literature and Recommendations for Management

Infections Caused byScedosporiumspp

Implantable cardioverter-defibrillator infection due to Scedosporium apiospermum

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