Bilateral Diffuse Uveal Melanocytic Proliferation Presenting as a Giant Unilateral Choroidal Nevus: A Case Report

Menezes, Carlos; Carvalho, Rui; Neves-Martins, Joana; Teixeira, Carla

doi:10.1159/000438944

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…After investigation, a lymphoma was discovered. Menezes 18 described a case of a 67-year-old male patient, with an elevated and pigmented macular lesion in the right eye with areas of giraffe-pattern pigmentation and an extensive retinal detachment. Left eye only showed a small hypopigmented area in the perimacular bundle, without evolution after 7 months of follow-up.…”

Section: Diffuse Uveal Melanocytic Proliferationmentioning

confidence: 99%

Unilateral Diffuse Uveal Melanocytic Proliferation: Case Report and Brief Review

Medina

Reis

Pereira

et al. 2024

RETINAL Cases &Amp; Brief Reports

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Purpose: To report a case of unilateral diffuse uveal melanocytic proliferation, in a patient with history of breast cancer, with bone and hepatic metastasis.Methods: Case report with funduscopic examination, fundus autofluorescence, and spectral-domain optical coherence tomography.Results: A 57-year-old female patient attended at our clinic for a routine glaucoma follow-up. Fundoscopy was normal on the right eye and showed multiple red patches in the posterior pole and inferior arcade. Multimodal examination was performed, compatible to diffuse uveal melanocytic proliferation on her left eye, and excluding other conditions, such as choroidal metastasis.Conclusion: Diffuse uveal melanocytic proliferation is a rare paraneoplastic condition, which usually is presented bilaterally. Unilateral cases of diffuse uveal melanocytic proliferation have been previously described only 5 times on the literature and are usually associated with breast cancer.

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Section: Diffuse Uveal Melanocytic Proliferationmentioning

confidence: 99%

Unilateral Diffuse Uveal Melanocytic Proliferation: Case Report and Brief Review

Medina

Reis

Pereira

et al. 2024

RETINAL Cases &Amp; Brief Reports

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“…Five reports of possible UDUMP have appeared in the literature, none of which were verify histologically. [18][19][20][21][22] Clinical follow-up when available was brief, averaging less than 6 months (Table, supplement). Since ocular sequential development of BDUMP is known to occur, the lack of sufficient clinical follow up raises concern that sequential or asymmetric ocular involvement had not been excluded.…”

Section: Unilateral Diffuse Uveal Melanocytic Proliferation (Udump)mentioning

confidence: 99%

Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy

et al. 2022

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Background: Dozens of paraneoplastic syndromes affect the visual system ranging from conjunctival pemphigoid to encephalopathy of the occipital cortex. The most profiled ocular syndromes are bilateral diffuse uveal melanocytic proliferation (BDUMP) and the autoimmune retinopathies. Purpose: To review the critical features of these 2 entities then concentrate on advancements in treatment made within the last 10 years. Study Design: Literature review with structured data abstraction. Results: Major insights into pathogenesis have been wanting. Plasmapheresis appears to improve vision in a substantial proportion of patients with BDUMP. The number of clinical variables that influence visual outcome in paraneoplastic retinopathies combined with the variety of local and systemic treatment options makes interpretation of clinical effectiveness difficult. Conclusions: The rarity of these disorders makes randomized clinical trials unlikely. It may be time for a clinical professional organization to use a modified Delphi method to establish a consensus algorithm for the diagnosis and management of retinal paraneoplastic syndromes to augment clinical communications and clinical trials.

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Diagnostic and therapeutic considerations in patients with bilateral diffuse uveal melanocytic proliferation

Kalogeropoulos,

Afshar,

De Salvo

et al. 2024

Int Ophthalmol

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Bilateral Diffuse Uveal Melanocytic Proliferation Presenting as a Giant Unilateral Choroidal Nevus: A Case Report

Cited by 5 publications

References 14 publications

Unilateral Diffuse Uveal Melanocytic Proliferation: Case Report and Brief Review

Unilateral Diffuse Uveal Melanocytic Proliferation: Case Report and Brief Review

Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy

Diagnostic and therapeutic considerations in patients with bilateral diffuse uveal melanocytic proliferation

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