Bilateral decrease in interictal hippocampal blood flow in unilateral mesiotemporal epilepsy

Rougier, Aline; Lurton, Dominique; Bahh, Bouchaib El; Lespinet, Véronique; Bidabé, A.M.; Guillot, M; Caillé, J. M.

doi:10.3171/jns.1999.90.2.0282

Cited by 12 publications

(8 citation statements)

References 40 publications

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“…Functionally, cerebral blood flow and volume was not altered in the hippocampus at 2 days post pilocarpine SE but was increased at 14 days when vessel density increased 23 . In human temporal lobe epilepsy bilateral decreases in cerebral blood flow were found in unilateral epilepsy which was unrelated to neuronal loss 42 . Given the paucity of studies on regional vessel density, use of different models and time points it is difficult to craft a picture of how the vasculature responds to SE.…”

Section: Discussionmentioning

confidence: 99%

Vascular topology is acutely impacted by experimental febrile status epilepticus

Salehi

Salari

Daglian

et al. 2022

Preprint

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Febrile status epilepticus (FSE) is an important risk factor for temporal lobe epilepsy and early identification is vital. In a rat model of FSE, we identified an acute novel MRI signal in the basolateral amygdala (BLA) at 2 hours post FSE that predicted epilepsy in adulthood. This signal remains incompletely understood and hypothesized that it might derive from changes to vascular topology. Experimental FSE was induced in rat pups and compared to normothermic littermate controls. We examined cerebral vascular topology at 2 hours, using a novel vessel painting and analysis protocol. Blood vessel density of the cortical vasculature was significantly reduced in FSE rats, and this effect was lateralized, as reported for the MRI signal. The middle cerebral artery (MCA) exhibited abnormal topology in FSE pups but not in controls. In the BLA, significant vessel junction reductions and decreased vessel diameter were observed, together with a strong trend for reduced vessel length. In summary, FSE results in acute vascular topological changes in the cortex and BLA that may underlie the acute MRI signal that predicts progression to future epilepsy. The altered vasculature may be amenable to intervention treatments to potentially reduce the probability of progression to epilepsy following FSE.

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Section: Discussionmentioning

confidence: 99%

Vascular topology is acutely impacted by experimental febrile status epilepticus

Salehi

Salari

Daglian

et al. 2022

Preprint

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“…XeCT CBF has also been used to demonstrate a region of increased flow as a marker for the site of seizure activity in patients with chronic epilepsy 122,123 (class IV).…”

Section: Marker Of Seizure Focusmentioning

confidence: 99%

Guidelines and Recommendations for Perfusion Imaging in Cerebral Ischemia

Latchaw¹,

Yonas²,

Hunter³

et al. 2003

Stroke

274

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“…Previous studies have followed this approach using an asymmetry index with a manual definition of the region of interest ( 5 – 9 ). This has been exploited for the detection of the epileptic focus with hypoperfusion or hypometabolism in interictal SPECT ( 5 ) or 18 F-fluorodeoxyglucose positron emission tomography ( 6 , 7 ) and hyperperfusion in internal carotid artery stenosis with post-surgery SPECT ( 8 , 9 ). However, its applicability in the diagnosis of epilepsy in comparison to P-I subtraction methods has not been established.…”

Section: Introductionmentioning

confidence: 99%

“…An asymmetry method, comparing ipsilateral and contralateral regions, can be performed by single acquisition of brain images as a clinically feasible method. Previous studies have followed this approach using an asymmetry index with a manual definition of the region of interest (5)(6)(7)(8)(9). This has been exploited for the detection of the epileptic focus with hypoperfusion or hypometabolism in interictal SPECT (5) or 18 F-fluorodeoxyglucose positron emission tomography (6,7) and hyperperfusion in internal carotid artery stenosis with post-surgery SPECT (8,9).…”

Section: Introductionmentioning

confidence: 99%

Developing an Asymmetry Method for Detecting Postictal Hyperperfusion in Poststroke Epilepsy

Fukuma

Takaya²,

Tojima

et al. 2022

Front. Neurol.

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Using dual single-photon emission computed tomography (SPECT) scanning, we recently found the postictal-interictal (P-I) subtraction method frequently detects prolonged postictal hyperperfusion in poststroke epilepsy (PSE) and thus may be valuable for auxiliary diagnosis. This study aimed to determine if the asymmetry method can localize hyperperfusion to reflect epileptic activity in PSE using a single postictal SPECT scan. Sixty-four patients with PSE who had undergone perfusion SPECT two times (postictal and interictal) were enrolled. We formulated a novel asymmetry method (subtraction analysis of reversed postictal SPECT from postictal SPECT, co-registered to magnetic resonance imaging) to identify paradoxical asymmetric increase, defined as a higher perfusion area adjacent to stroke lesions compared to the contralateral side. The postictal hyperperfusion area and detection rates were determined by the asymmetry and P-I subtraction methods independently. We subsequently calculated the sensitivity and specificity of the asymmetry method, compared to the gold standard P-I subtraction method. We also evaluated lateralization concordance between the asymmetry method and other clinical findings. Among 64 patients (median age, 75 years), prolonged postictal hyperperfusion was detected in 43 (67%) by the asymmetry, and 54 (84%) the P-I, method. The asymmetry method had high sensitivity (80%) and specificity (100%) in detecting postictal hyperperfusion, showing high lateralization concordance with seizure semiology (97%) and epileptiform electroencephalography findings (interictal/ictal epileptiform discharges or periodic discharges) (100%). The present study demonstrated the advantages of the objective asymmetry method for detecting prolonged hyperperfusion through using one postictal SPECT scan in PSE.

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Bilateral decrease in interictal hippocampal blood flow in unilateral mesiotemporal epilepsy

Cited by 12 publications

References 40 publications

Vascular topology is acutely impacted by experimental febrile status epilepticus

Vascular topology is acutely impacted by experimental febrile status epilepticus

Guidelines and Recommendations for Perfusion Imaging in Cerebral Ischemia

Developing an Asymmetry Method for Detecting Postictal Hyperperfusion in Poststroke Epilepsy

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