Bilateral choroidal detachment and myopic shift after acetazolamide intake for laser capsulotomy

Musetti, Donatella; Nicolò, Massimo; Bagnis, Alessandro; Cutolo, Carlo Alberto; Traverso, Carlo Enrico

doi:10.1177/1120672120974284

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…The timings symptom-onset, choroidal detachment and symptom-resolution were similar to reported cases in which acetazolamide has been used prophylactically in ocular surgery. Symptoms are usually present the next day, as in our case, and fully resolve by 5–14 days 7 8. Our case had resolution of symptoms at 7 days.…”

Section: Discussionsupporting

confidence: 69%

Bilateral choroidal effusions after taking acetazolamide for altitude sickness

Rothwell¹,

Anderson²

2022

BMJ Case Rep

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A fit and healthy 44-year-old woman took a single dose of oral acetazolamide (125 mg) in preparation for a hiking trip to Everest base camp. She awoke the next morning with profoundly blurred distance vision. She presented to eye casualty later that morning, approximately 18 hours postingestion: examination demonstrated myopia and bilateral choroidal effusions. Acetazolamide is used to minimise symptoms of altitude sickness. Rarely, its use can be linked with ophthalmic side effects, such as myopia. A handful of case reports also describe choroidal effusions secondary to its use as part of ophthalmic treatment (eg, postoperatively). This is the first reported case in which choroidal effusions have been demonstrated as a side effect of its prophylactic use against altitude sickness.

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Section: Discussionsupporting

confidence: 69%

Bilateral choroidal effusions after taking acetazolamide for altitude sickness

Rothwell¹,

Anderson²

2022

BMJ Case Rep

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“…Sulfonamideʼs derivatives, such as topiramate, hydrochlorothiazide, and acetazolamide, have been rarely reported to induce ciliochoroidal effusion 3 , 4 . Acetazolamide administration, specifically, has been associated with a transient myopic shift, iridocorneal angle closure with or without ocular hypertension, and a ciliochoroidal detachment 1 , 5 – 23 . To our knowledge, this rare adverse reaction has only been reported in 23 patients since 1956, including our patient ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

“…A uveal effusion was observed in about half of the patients. When acetazolamide was stopped, all cases recovered completely after a median of 5 days (2 – 14), with the aid of additional cycloplegia, anti-glaucomatous agents, and/or steroid treatment in about a quarter, a third, and more than half of the patients, respectively 1 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 .…”

Section: Discussionmentioning

confidence: 99%

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Acute Myopic Shift after a Single Dose of Acetazolamide: A Case Report and Review of the Literature

Kaisari,

Abouzeid,

Magnin

et al. 2024

Klin Monbl Augenheilkd

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We report the case of a 32-year-old male who presented with an acute myopic shift as a result of uveal effusion following a single administration of 250 mg acetazolamide. The drug was discontinued and following cycloplegia and topical steroid therapy, we observed progressive deepening of the anterior chamber, reopening of the iridocorneal angle, and complete resolution of the myopic shift after 5 days. A literature review since 1956 identified 23 cases, including ours, which developed a myopic shift after a median time of 24 h (3 – 24) following a median dose of 500 mg (125 – 1000) acetazolamide, with about a third complicated by angle closure ocular hypertension. This presumed idiosyncratic reaction can occur without prior drug exposure and independent of the phakic status. Treatment options include systematic drug withdrawal associated with cycloplegia, anti-glaucomatous agents, and/or corticosteroids. Full recovery is achieved within about 5 days (2 – 14). Given the widespread use of acetazolamide, awareness of this idiosyncratic reaction is crucial to avoid complications of acute angle-closure glaucoma.

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“…Sulfa drugs (e.g., topiramate, acetazolamide, hydrochlorothiazide, methazolamide) [ 6 , 69 , 73 – 78 ]…”

Section: Introductionmentioning

confidence: 99%

Medical Therapy and Scleral Windows for Uveal Effusion Syndrome: A Case Series and Literature Review

Hunter

Thomson

et al. 2022

Ophthalmol Ther

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Introduction: Uveal effusion syndrome (UES) is a rare ocular disease causing idiopathic uveal effusion, often with associated ciliochoroidal and retinal detachment. UES diagnosis is challenging because of overlapping features with other ocular inflammatory, neoplastic, iatrogenic, and drug-induced causes of uveal effusion. While several successful surgical treatments have been described, such as fullthickness or partial-thickness sclerectomy, medical therapies may also have a therapeutic role.Objective: To provide an updated review of the published literature on the course of the disease, medical and surgical management strategies, as well as newer treatment modalities.

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Bilateral choroidal detachment and myopic shift after acetazolamide intake for laser capsulotomy

Cited by 5 publications

References 8 publications

Bilateral choroidal effusions after taking acetazolamide for altitude sickness

Bilateral choroidal effusions after taking acetazolamide for altitude sickness

Acute Myopic Shift after a Single Dose of Acetazolamide: A Case Report and Review of the Literature

Medical Therapy and Scleral Windows for Uveal Effusion Syndrome: A Case Series and Literature Review

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