Bilateral Cerebral Mediofrontal Hypoactivity in Tc-99m HMPAO SPECT Imaging

Cerebral perfusion pattern of idiopathic normal pressure hydrocephalus studied by SPECT and statistical brain mapping

“…A previous report described the relationship of urinary incontinence and the relative hypoperfusion area in the medial frontal lobe. 26 The area that we showed to have a more decreased CBF area in the urinary incontinence group matched the area shown as the region particularly important for the control of micturition. 27 Griffiths et al 2s reported that genuine urge incontinence with reduced bladder filling sensation was associated with a global decrease of the CBF and, more specifically, with hypoperfusion of the frontal areas of the brain, especially on the right, and suggested that their findings are consistent with PET scan observations, which showed that areas in the right anterior cingulate gyrus and right inferior frontal gyrus were involved in voluntary voiding in normal males.…”

Idiopathic normal-pressure hydrocephalus, cortical thinning, and the cerebrospinal fluid tap test

“…For example, most previous studies about cerebral perfusion patterns in iNPH patients emphasize diffuse or frontal dominant cerebral blood flow reduction [43,44], and frontal hypoperfusion and frontal subcortical white matter disintegration were also associated with symptoms including urinary incontinence and gait disturbance in iNPH patients [43,45,46]. Additionally, there was evidence that impaired functioning in the superior frontal gyrus could play a role in shunt-responsiveness of iNPH [44].…”

Identification of brain structures involved in micturition with functional magnetic resonance imaging (fMRI)

“…Urinary incontinence in poststroke patients was described by other authors [19][20][21]. Denays et al [22] describe bilateral cerebral mediofrontal hypoactivity in Tc-99m HMPAO SPECT, which was associated with various neurologic disorders, including urinary incontinence. Other SPECT scanning investigations demonstrated in patients with urge incontinence and reduced bladder Figure 1 Functional MRI maps of the experiment in two volunteers: increased brain activity was found in the inferior frontal gyrus, predominantly on the right side (A,C,D,F).…”