Bilateral central toxic keratopathy after laser in situ keratomileusis

Abd‐Elmaksoud, Ahmed; Khoo, Nigel Terk-Howe; Hanoot, Hala; Ibrahim, Osama

doi:10.1136/bcr-2015-212423

Cited by 6 publications

(8 citation statements)

References 17 publications

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“…In addition, recent in vivo confocal microscopy findings in CTK did not support inflammatory cells in CTK but showed keratocyte loss in contrast to steroid-sensitive DLK. Collectively, these findings further provide limited support regarding the role of steroids in the management of CTK 7 , 11 , 12 . Despite these controversial treatment recommendations, we thought that steroid treatment had a pronounced effect on recovery, and we were able to get a good response to a potent steroid in a short time.…”

Section: Discussionmentioning

confidence: 86%

“…Collectively, these findings further provide limited support regarding the role of steroids in the management of CTK. [7,11,12] Despite these controversial treatment recommendations, we thought that steroid treatment had a pronounced effect on recovery and we were able to get a good response to a potent steroid in a short time. Since washing the corneal interface in these patients would increase the pathology more, we never thought of interface washing.…”

Section: Accepted Manuscriptmentioning

confidence: 95%

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Central Toxic Keratopathy after Small Incision Lenticule Extraction

Gülmez

Fatihoglu

2022

Klin Monbl Augenheilkd

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Small incision lenticule extraction (SMILE) is a corneal refractive surgical procedure based on flapless extraction of the intrastromal lenticule created by a femtosecond laser. Central toxic keratopathy is a rare, non-inflammatory complication of flap laser surgery using the femtosecond laser. This disorder is typically characterized by the triad of noninflammatory central corneal opacification, striae, and loss of stromal bed tissue, and it results in a hyperopic shift that causes a reduction in vision quality and it is not among the complications we are familiar with after the SMILE. Because of the growing number of refractive surgical procedures worldwide there may be an increasing incidence of this disorder. A differentiation from an inflammatory or infectious etiology and appropriate treatment is necessary for recovery. In this case report, we report a case of central toxic keratopathy in a 25 years old male patient after SMILE laser surgery.

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Section: Discussionmentioning

confidence: 86%

Section: Accepted Manuscriptmentioning

confidence: 95%

Central Toxic Keratopathy after Small Incision Lenticule Extraction

Gülmez

Fatihoglu

2022

Klin Monbl Augenheilkd

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“…Central toxic keratopathy (CTK), a rare complication after laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK), is characterized by central corneal opacities and hyperopic shifts. 3 , 4 Tissue destruction due to abnormal secretion of MMPs has been suggested to be the pathogenesis of CTK. 4 Our patient had not undergone LASIK or PPK but similar processes of tissue destruction might have occurred.…”

Section: Discussionmentioning

confidence: 99%

Case of progressive hyperopia due to flattening of cornea

Hirai

Maruoka

Yoshikawa

et al. 2018

American Journal of Ophthalmology Case Reports

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PurposeTo report a case that had a progressive decrease in the visual acuity caused by a progressive increase in the hyperopia due to a flattening of the cornea.ObservationsA 50-year-old woman complained of decreased vision in both eyes. Her decimal best-corrected visual acuity was 1.2 in the right and 0.5 in the left eyes, and the refractive error (spherical equivalent) was +3.75 diopters (D) for the right eye and +6.5 D for the left eye. Slit-lamp examinations showed clear corneas but Descemet‘s folds and fine pigmentations and opacities were present beneath the corneal epithelium in both eyes. Analysis of the corneal shape by anterior segment optical coherence tomography showed that the corneas were flattened, and the corneal refractive power was decreased in both eyes. The large values of the higher-order aberration in the cornea and total eye displayed bilateral irregular astigmatism. She obtained good vision by wearing hard contact lenses but her refractive power continued to decrease for at least 1 year.Conclusionsand Importance: We report a rare case of progressive hyperopia and irregular astigmatism due to a flattening of the cornea. Folds were present in Descemet‘s membrane but the cornea was not edematous.

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“…Forty case reports, reviews, and other articles in the peerreviewed literature between 1986 and 2019 relating to the topic of TASS (Table 3). Another 22 reports and articles on DLK [1][2][3][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63] (Table 4) were identified. Only 5 of these 62 total studies reported specifically investigating the potential role of autoclave reservoirs and their associated biofilms as the potential cause of TASS or DLK.…”

Section: Literature Reviewmentioning

confidence: 99%