Bilateral breast involvement in Sézary syndrome

Abstract

Cutaneous T-cell lymphoma is a term used for mycosis fungoides and Sézary syndrome, the distinct clinical entities where the skin is the primary organ of involvement. Sézary syndrome is the leukemic variant of mycosis fungoides, presenting with generalized erythroderma, lymphadenopathy, and atypical cells (the Sézary cells) in the peripheral blood and bone marrow. The dissemination of cutaneous T-cell lymphoma may occur with no exception of the organs; however, no prior report exists about the Sézary syndrome secondarily involving the breasts. We report the clinical and radiological findings of bilateral breast involvement in a case of Sézary syndrome.

Breast: Sezary Syndrome: A Unique Presentation

“…Most breast lymphomas are of B cell origin . T cell lymphomas of the breast and two cases of SS are also described in the literature.…”

“…Dissemination to organs is rare and is usually late in the course of the disease. Involvement of the breast is extremely rare with only two documented cases in the literature . “(RC1)” In this case report, we describe an unusual presentation of SS involving a right breast intramammary lymph node (IMLN) that was discovered on a routine screening mammogram, preceding the patient's skin rash.…”