Bilateral breast involvement in acute myelogenous leukemia

Khoury, Nabil; Al-Kass, F. M. Hanna; Jaafar, Hassan; Taher, Ali T.; Shamseddine, Ali

doi:10.1007/s003300051059

Cited by 21 publications

(18 citation statements)

References 2 publications

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“…Of 235 patients with AML, only four had involvement of the breast (1.7%). Although few cases have been described, breast infiltration seems more likely to occur in patients with AML rather than those with ALL [34]. The mechanism of extramedullary infiltration is unclear.…”

Section: Discussionmentioning

confidence: 99%

Relapse of Biphenotypic Acute Leukemia as a Breast Mass

Shin

2016

J Breast Cancer

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In acute leukemia, leukemic infiltration of the breast is extremely rare. We report a case of biphenotypic acute leukemia (BAL) that presented as a breast mass. A 30-year-old woman presented with a 4-month history of a right breast mass with nipple discharge and easy fatigue. She had received chemotherapy and peripheral blood stem cell transplantation for BAL and had been in complete remission for the last 2 years. Core needle biopsy of the breast mass revealed monomorphous infiltrates of blast cells with round nuclei and fine chromatin, consistent with leukemic infiltration. Subsequent bone marrow biopsy showed diffuse infiltration of immature cells. However, bone marrow karyotyping showed 46, XY, suggesting complete engraftment of transplanted donor cells. This is the report of BAL recurring as a breast mass. In the differential diagnosis of a breast mass, extramedullary relapse should be considered when the patient has a history of leukemia.

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Section: Discussionmentioning

confidence: 99%

Relapse of Biphenotypic Acute Leukemia as a Breast Mass

Shin

2016

J Breast Cancer

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“…The ultrasound observations for GS of the breast are absent of characteristic appearances and often present as a hypoechoic and well-defined mass, with color flow imaging and without areas of calcification (7). Few case reports have previously described the mammographic appearance of GS of the breast (8,9). GS has been commonly described as a non-calcified mass in the breast.…”

Section: Discussionmentioning

confidence: 99%

Granulocytic sarcoma of the breast in acute myeloid leukemia: Two case reports

Luo

2013

Oncology Letters

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Granulocytic sarcoma (GS) of the breast is extremely rare in patients with acute myeloid leukemia (AML) and therefore, is often misdiagnosed as lymphoma or other benign tumors. The current report presents two cases of GS of the breast, of which, one was considered to be a fibroma, as observed by fine-needle aspiration, and the other was misdiagnosed as lymphoma by frozen section. Previous literature that described the clinical and pathological characteristics, treatments and prognosis of GS of the breast in AML were reviewed. In addition to the treatment of mastectomy with/without radiotherapy, lumpectomy may also be received as a good treatment plan.

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“…The involvement of the breasts in cases of acute myeloid leukemia has been described as areas of mixed echogenicity, with or without acoustic shadowing (2, 10). Another study described the microscopic results of breast involvement in an acute leukemia case study of an autopsy series (1).…”

Section: Discussionmentioning

confidence: 99%

“…The mammographic findings in cases of leukemia in the breasts can be normal (5, 6), enlarged with diffusely coarse breast parenchyma (2), ill-defined margin with an irregular shaped mass (5, 6), or well-defined bordered lesions with a benign appearance (6). …”

Section: Discussionmentioning

confidence: 99%

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Acute Lymphoblastic Leukemia Presented as Multiple Breast Masses

et al. 2009

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Breast metastases in cases leukemia are very rare and occur primarily in patients with acute myeloid leukemia. We report the involvement of breast metastases in a 30-year-old woman with acute T cell lymphoblastic leukemia. The patient's mammograms revealed an extremely dense pattern with ill-defined, denser mass-like lesions in both breasts. A bilateral breast ultrasonographic evaluation revealed lobular-shaped and partly ill-defined hypoechoic masses with a multi-septated nodular (mottled) appearance.

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Bilateral breast involvement in acute myelogenous leukemia

Cited by 21 publications

References 2 publications

Relapse of Biphenotypic Acute Leukemia as a Breast Mass

Relapse of Biphenotypic Acute Leukemia as a Breast Mass

Granulocytic sarcoma of the breast in acute myeloid leukemia: Two case reports

Acute Lymphoblastic Leukemia Presented as Multiple Breast Masses

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