Bilateral breast cancer in China: A 10‐year single‐center retrospective study (2006–2016)

Jiang, Hanfang; Zhang, Ruyan; Liu, Xiaoran; Ran, Ran; Zhang, Jiayang; Liu, Yaxin; Gui, Xinyu; Chen, Yifei; Li, Kun; Shao, Bin; Yan, Ying; Xu, Liang; Song, Gonghua; Di, Lijun; Li, Huiping

doi:10.1002/cam4.4141

Cited by 8 publications

(4 citation statements)

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“…19 Consider unpredictable metachronous BBC has higher mortality than synchronous BBC, 12,15 and recent study has displayed metachronous primary BBC has better prognosis than synchronous BBC. 15,20 We evaluated the risks for metachronous primary BBC and synchronous BBC after the second breast surgery for patients with non-metastatic BC, so the rst-site-locoregional recurrence was compared concerning special survival and CRD risks. 21 Furthermore, we found differences in annual pattern of incidence according to metastatic sites and cancer-related deaths, which is largely consistent with the research.…”

Section: Discussionmentioning

confidence: 99%

Nomograms to Predict Individual Potential Benefit from Targeted Therapy for patients with lymph node positive Luminal B (HER2-) breast cancer

Yue,

Meng,

et al. 2024

Preprint

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Purpose To construct nomograms combining clinicopathological characteristics, bone metastases (BM), viscera metastases (VM) and cancer-related deaths (CRD) to predict the higher-risk patients with lymph node positive (N+) Luminal B (HER2-) breast cancer (BC). Method Kaplan-Meier survival analysis, Venn diagram, Bar charts were used to describe the data for subsequent metastasis and CRD. Thirty-six clinicopathological characteristics were extracted in univariate and multivariate Cox regression analyses to develop nomogram to predict potential risk of BM, VM and CRD among patients with N+ Luminal B (HER2-) BC. The calibration plots, concordance index and receiver operating characteristics (ROC) analysis were applied to determine the nomogram accuracy. Result The median age of 8139 patients was 51 years, with a median follow-up of 124 months (4–216 months). There was no statistical difference between the metachronous primary bilateral BC and synchronous primary bilateral BC. The number-peak period of patients with subsequent BM was the third year, VM was the 4th year and CRD was the 6th year (range second–6th year, 4th–6th year and third–8th year, respectively). BM, VM and CRD nomograms showed outstanding performance and discriminative ability (C-index 0.69, 0.68 and 0.71, respectively). The calibration curves and ROC curves analysis demonstrated the considerable clinical usefulness of the combined nomogram. Three clinical examples showed results differences in optimal period who had similar pathological stage. Conclusion The developed nomogram model consisting of time-event-dependent clinicopathological characteristics could reliable in predicting BM, VM and CRD probability of patients with N+ Luminal B (HER2-) BC.

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Section: Discussionmentioning

confidence: 99%

Nomograms to Predict Individual Potential Benefit from Targeted Therapy for patients with lymph node positive Luminal B (HER2-) breast cancer

Yue,

Meng,

et al. 2024

Preprint

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“…In other countries, bilateral BCs are equally uncommon and demonstrate an increased risk of recurrence, metastasis, relapse and overall poor survival compared to unilateral BC. [36][37][38][39] There were 49 BRCA-positive patients, and the majority were…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the prevalence and general lack of data in SA indicate that bilateral and recurrent BCs are rare both in KZN and nationally. In other countries, bilateral BCs are equally uncommon and demonstrate an increased risk of recurrence, metastasis, relapse and overall poor survival compared to unilateral BC 36‐39 …”

Section: Discussionmentioning

confidence: 99%

Recent trends in hereditary breast cancer incidence by race and age in KwaZulu‐Natal, South Africa: An 11‐year single‐centre retrospective study (2011‐2021)

Makhetha

Chabilal²,

Aldous

2023

Intl Journal of Cancer

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Breast cancer incidence has increased globally in the last decade, especially in low‐ and middle‐income countries. In Sub‐Saharan Africa, breast cancer trends have been described only in a few populations owing to the scarcity of population‐specific data. Using data collected between 2011 and 2021 at Inkosi Albert Luthuli Central Hospital, this retrospective study describes demographic and genetic trends for hereditary breast cancer patients in the KwaZulu‐Natal province, South Africa. Six hundred and forty‐five patients were included, of whom 44.3% were Black, 36.8% Indian, 15.6% White and 3.2% Coloured. The number of annual new cases increased from eight in 2011 to 145 in 2021, with a notable increase among Blacks. The mean onset age was 46 years, and Black patients were diagnosed ~10 years earlier than White and Indian patients. Triple‐negative breast cancers accounted for 20.3% of hereditary cases, and 51.1% of them were Black. Bilateral and recurrent breast cancers constituted 7.4%, while pathogenic sequence variants in BRCA1/2 were reported in 10.4% of all patients, and the majority were Blacks and Indians. Overall, the KwaZulu‐Natal province has seen an increase in hereditary breast cancer incidence in the past decade. Despite testing negative for pathogenic sequence variants, Black women frequently presented with breast cancers that are BRCA1‐like, while Indians presented with extensive family history. This suggests that South African patients may require unique approaches to interventions, such as early detection and awareness programs among Blacks and increased genetic screening among Indians.

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“…According to the aforementioned aims, this study focuses on patients with a diagnosis of pure unilateral DCIS at CNB/VAB, as the presence of ipsilateral and/or contralateral invasive cancer and the presence of bilateral DCIS are known to influence surgical management [ 35 , 36 ], acting as strong potential confounding factors.…”

Section: Methodsmentioning

confidence: 99%

Preoperative breast MRI positively impacts surgical outcomes of needle biopsy–diagnosed pure DCIS: a patient-matched analysis from the MIPA study

Cozzi,

Di Leo,

Houssami

et al. 2023

Eur Radiol

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Objectives To investigate the influence of preoperative breast MRI on mastectomy and reoperation rates in patients with pure ductal carcinoma in situ (DCIS). Methods The MIPA observational study database (7245 patients) was searched for patients aged 18–80 years with pure unilateral DCIS diagnosed at core needle or vacuum-assisted biopsy (CNB/VAB) and planned for primary surgery. Patients who underwent preoperative MRI (MRI group) were matched (1:1) to those who did not receive MRI (noMRI group) according to 8 confounding covariates that drive referral to MRI (age; hormonal status; familial risk; posterior-to-nipple diameter; BI-RADS category; lesion diameter; lesion presentation; surgical planning at conventional imaging). Surgical outcomes were compared between the matched groups with nonparametric statistics after calculating odds ratios (ORs). Results Of 1005 women with pure unilateral DCIS at CNB/VAB (507 MRI group, 498 noMRI group), 309 remained in each group after matching. First-line mastectomy rate in the MRI group was 20.1% (62/309 patients, OR 2.03) compared to 11.0% in the noMRI group (34/309 patients, p = 0.003). The reoperation rate was 10.0% in the MRI group (31/309, OR for reoperation 0.40) and 22.0% in the noMRI group (68/309, p < 0.001), with a 2.53 OR of avoiding reoperation in the MRI group. The overall mastectomy rate was 23.3% in the MRI group (72/309, OR 1.40) and 17.8% in the noMRI group (55/309, p = 0.111). Conclusions Compared to those going directly to surgery, patients with pure DCIS at CNB/VAB who underwent preoperative MRI had a higher OR for first-line mastectomy but a substantially lower OR for reoperation. Clinical relevance statement When confounding factors behind MRI referral are accounted for in the comparison of patients with CNB/VAB-diagnosed pure unilateral DCIS, preoperative MRI yields a reduction of reoperations that is more than twice as high as the increase in overall mastectomies. Key Points • Confounding factors cause imbalance when investigating the influence of preoperative MRI on surgical outcomes of pure DCIS. • When patient matching is applied to women with pure unilateral DCIS, reoperation rates are significantly reduced in women who underwent preoperative MRI. • The reduction of reoperations brought about by preoperative MRI is more than double the increase in overall mastectomies.

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Bilateral breast cancer in China: A 10‐year single‐center retrospective study (2006–2016)

Cited by 8 publications

References 50 publications

Nomograms to Predict Individual Potential Benefit from Targeted Therapy for patients with lymph node positive Luminal B (HER2-) breast cancer

Nomograms to Predict Individual Potential Benefit from Targeted Therapy for patients with lymph node positive Luminal B (HER2-) breast cancer

Recent trends in hereditary breast cancer incidence by race and age in KwaZulu‐Natal, South Africa: An 11‐year single‐centre retrospective study (2011‐2021)

Preoperative breast MRI positively impacts surgical outcomes of needle biopsy–diagnosed pure DCIS: a patient-matched analysis from the MIPA study

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