Bilateral Basal Ganglia Lesion after Glufosinate Ammonium (BASTA<sup>®</sup>) Intoxication

Abstract

Background: Glufosinate ammonium (Basta®) was developed in Japan in 1994 and was introduced to Korea as a non-selective herbicide. Recently, there is increasing concern about the glufosinate ammonium (GLA) intoxication. Case Report: We report a bilateral basal ganglia lesion that developed after Basta® ingestion. Hippocampal cytotoxic edema is usually encountered after GLA intoxication because profound hypotension or prolonged generalized tonic clonic seizures are usually accompanied. However, profound hypotensive episode or elevated creatine kinase was not observed during the hospital admission. After conservative ventilator support and antibiotic care for aspiration pneumonia, the patient was discharged to a chronic care facility. Conclusion: Bilateral striatal lesion except hippocampal involvement is one of the features of GLA intoxication. Toxic properties for GLA and other additives in Basta® should be thoroughly investigated.

A Narrative Review of Contemporary Lethal Pesticides: Unveiling the Ongoing Threat of Pesticide Poisoning

“…In the clinical course of acute GAH poisoning (85,86,(89)(90)(91)(92)(93)(94), the following should be noted: 1) "Frequent elevation of plasma ammonia levels" from the early phase of poisoning, 2) The presence of "various CNS toxic symptoms and signs", necessitating critical care support in moderate to severe poisoning, 3) The potential for "a latent period up to 48 hours" following GAH exposure Management If the patient seeks medical attention within 1 hour of ingestion, gastric lavage is performed, and activated charcoal should be administered. Activated charcoal administration can help treat up to several hours after exposure.…”

Neurotological Findings in a Patient with Glufosinate Ammonium Intoxication

“…Various neurological symptoms including loss of consciousness, convulsion, and memory impairment due to acute GLA intoxication have been reported [1][2][3][4][5][6][7]. However, no study has reported brainstem and cerebellar dysfunction associated with GLA.…”