Bilateral Anterior Uveitis Associated with Clomiphene Citrate

Myers, Thomas D.; Fraunfelder, Fredrick W.

doi:10.1080/09273940701799155

Cited by 10 publications

(2 citation statements)

References 4 publications

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“…Similarly, the postpartum decrease in female hormones is thought to increase the risk of uveitis 18 . There was a case report on a PCOS patient with bilateral anterior uveitis after using clomiphene citrate, an anti-estrogen used to induce ovulation 19 . This also suggests the anti-inflammatory potential of female hormones in the development of uveitis.…”

Section: Discussionmentioning

confidence: 99%

Association between polycystic ovary syndrome and non-infectious uveitis

Lee

et al. 2023

Sci Rep

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Polycystic ovary syndrome (PCOS) is a common endocrine disease in young women. It has been reported that increased proinflammatory cytokines can induce systemic inflammation. However, the association between PCOS and uveitis remains elusive. In this study, we investigate the possible association between PCOS and uveitis using Korean National Health Insurance Service-National Sample Cohort. The incidence of non-infectious uveitis was compared between patients with and without PCOS before and after propensity score matching. Hazard ratios were determined using univariate and multivariate Cox regression models. Of 558,302 female participants, 2039 had PCOS and 8122 had non-infectious uveitis. The incidence of non-infectious uveitis was 35.1 per 10,000 person-years in the PCOS patients compared to 16.6 in non-patients (P < .001). This tendency remained after 1:3 propensity score matching. The hazard ratio of PCOS using a multivariate Cox regression model was 2.79 (95% CI, 1.92–4.05; P < .001) and 2.87 (95% CI, 1.77–4.67; P < .001) before and after matching, respectively. Our results suggests that PCOS is associated with non-infectious uveitis, particularly in women of reproductive age. This may be due to hormonal changes and proinflammatory factors. Future investigations should examine the clinical features and underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Association between polycystic ovary syndrome and non-infectious uveitis

Lee

et al. 2023

Sci Rep

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“…Myers and Fraunfelder 98 reported a patient who developed bilateral anterior uveitis while on ovulation induction therapy with clomiphene. The patient was treated with topical steroids successfully but developed a recurrence of the bilateral anterior uveitis on rechallenge with clomiphene 3 months later.…”

Section: Clomiphenementioning

confidence: 99%

Drug-induced Uveitis

Shifera¹,

Kopplin²,

Lin³

et al. 2015

International Ophthalmology Clinics

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Current awareness: Pharmacoepidemiology and drug safety

2008

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Bilateral Anterior Uveitis Associated with Clomiphene Citrate

Abstract: Ovulation induction therapy with clomiphene citrate may precipitate uveitis.

Cited by 10 publications

References 4 publications

Association between polycystic ovary syndrome and non-infectious uveitis

Association between polycystic ovary syndrome and non-infectious uveitis

Drug-induced Uveitis

Current awareness: Pharmacoepidemiology and drug safety

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