Bilateral age-related atrophy in the planum temporale is associated with vowel discrimination difficulty in healthy older adults

Isler, Benjamin; Giroud, Nathalie; Hirsiger, Sarah; Kleinjung, Tobias; Meyer, Martin

doi:10.1016/j.heares.2021.108252

Cited by 6 publications

(7 citation statements)

References 108 publications

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“…Isler et al . 33 pointed out that age-related atrophy of the bilateral temporal plane was associated with difficulty in distinguishing vowels in healthy elderly people. There was a significant aging phenomenon in the function and structure of this area 34 that led to a decline in its function with increasing age.…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between multiparameter brain MRI phenotypes and age: evidence from Mendelian randomization

Wang,

Chen,

Liu

et al. 2024

Brain Communications

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To explore the causal relationship between age and brain health (cortical atrophy, white matter integrity, white matter hyperintensities, and cerebral microbleeds in various brain regions) related multiparameter imaging features using two-sample Mendelian randomization. Age was determined as chronological age of the subject. Cortical volume, white matter micro-integrity, white matter hyperintensity volume, and cerebral microbleeds of each brain region were included as phenotypes for brain health. Age and imaging of brain health related genetic data were analyzed to determine the causal relationship using inverse-variance weighted model, validated by heterogeneity and horizontal pleiotropy variables. Age is causally related to increased volumes of white matter hyperintensities (β= 0.151). For white matter micro-integrity, fibers of the inferior cerebellar peduncle (Axial diffusivity β= -0.128, orientation dispersion index β= 0.173), cerebral peduncle (Axial diffusivity β= -0.136), superior fronto-occipital fasciculus (isotropic volume fraction β= 0.163) and fibers within the limbic system were causally deteriorated. We also detected decreased cortical thickness of multiple frontal and temporal regions (p<0.05). Microbleeds were not related with aging p＞0.05). Aging is a threaten of brain health, leading to cortical atrophy mainly in the frontal lobes, as well as the white matter degeneration especially abnormal hyperintensity and deteriorated white matter integrity around the hippocampus.

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Section: Discussionmentioning

confidence: 99%

Causal relationship between multiparameter brain MRI phenotypes and age: evidence from Mendelian randomization

Wang,

Chen,

Liu

et al. 2024

Brain Communications

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“…Regarding variables of interest, superiority of use of constituent components of volume (surface area, thickness, and gyrification) was effectively emphasised nearly 10 years ago [28,60] and appears to have been well adopted since [e.g., 20,26,63]. Our aim was to further verify the value of surface area as well as thickness and local gyrification as variables when studying morphometrical asymmetry.…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…Here, morphometrical and connective both refer to structural measures: physical properties of the brain obtained with magnetic resonance imaging (MRI). The planum temporale is the emphasised due to being the foremost regionof-interest (ROI) in studies of lateralisation of speech [24][25][26][27]. Surface area is emphasised as the primary variable of interest to likewise adhere to extant trends in the literature [28,29].…”

Section: Study Aimsmentioning

confidence: 99%

Morphometrical asymmetries and tractography of speech-relevant cortex in relation to language lateralisation and rapid temporal processing

Bourke,

Cooper,

Forstmann

et al. 2024

Preprint

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Differences in the functional roles of the left and right cortices for speech-related processes have been known since the findings of Broca [1] and Wernicke [2]. Nearly 100 years later anatomical asymmetries of speech-related cortex was emphasised as a potential substrate to such functional lateralisations [3]. Exploration of associations of anatomical asymmetries and functional lateralisations in speech has since continued, with developing technologies and theoretical insights mutually affording increasingly refined understandings. The present study is another such continuance; we outline and report associations of neuroanatomical (morphometrical) and connective (diffusion tractography) measures of speech-related cortex with differences of participant speech lateralisation and rapid temporal acuity (a hypothesised general auditory ability that contributes to superior speech processing). Review and support of developments in methodological approaches to morphometry and tractography to are also provided. Overall, our study affirms complex and selectively overlapping relationships of anatomy and connectivity (especially in the planum temporale) with behavioural language lateralisation and the processing of rapid temporal acoustics. Implications, limitations, and recommendations are discussed.

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“…Different correlations between atrophy in AC areas and behavior between younger and older adults were also observed. By investigating the PT, older adults showed bilateral lower cortical volume, thickness and surface area (Isler et al, 2021 ). In older adults, these values correlated positively with performance in vowel discrimination meaning that higher atrophy was associated with lower performance.…”

Section: Anatomical Alterationsmentioning

confidence: 99%

Asymmetries and hemispheric interaction in the auditory system of elderly people

Angenstein

2024

Front. Neuroimaging

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Age-related changes of asymmetries in the auditory system and decreasing efficiency of hemispheric interaction have been discussed for some time. This mini-review discusses recent neuroimaging studies on alterations in lateralization of cortical processing and structural changes concerning the division of labor and interaction between hemispheres during auditory processing in elderly people with the focus on people without severe hearing loss. Several changes of asymmetries in anatomy, function and neurotransmitter concentration were observed in auditory cortical areas of older compared to younger adults. It was shown that connections between left and right auditory cortex are reduced during aging. Functionally, aging seems to lead to a reduction in asymmetry of auditory processing. However, the results do not always point into the same direction. Furthermore, correlations between function, anatomy and behavior in the left and right hemisphere appear to differ between younger and older adults. The changes in auditory cortex asymmetries with aging might be due to compensation of declining processing capacities, but at the same time these mechanisms could impair the balanced division of labor between the two hemispheres that is required for the processing of complex auditory stimuli such as speech. Neuroimaging studies are essential to follow the slow changes with aging as in the beginning no behavioral effects might be visible due to compensation. Future studies should control well for peripheral hearing loss and cognitive decline. Furthermore, for the interpretability of results it is necessary to use specific tasks with well-controlled task difficulty.

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Bilateral age-related atrophy in the planum temporale is associated with vowel discrimination difficulty in healthy older adults

Cited by 6 publications

References 108 publications

Causal relationship between multiparameter brain MRI phenotypes and age: evidence from Mendelian randomization

Causal relationship between multiparameter brain MRI phenotypes and age: evidence from Mendelian randomization

Morphometrical asymmetries and tractography of speech-relevant cortex in relation to language lateralisation and rapid temporal processing

Asymmetries and hemispheric interaction in the auditory system of elderly people

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