Bilateral adrenal neuroblastoma

Abstract

Bilateral adrenal neuroblastoma is extremely rare, with isolated case reports considered to represent metastatic spread rather than simultaneous occurrence. This patient was found to have synchronous, separate, and equal size neoplasms that morphologically and ultrastructurally are neuroblastoma. We believe that these findings represent the unusual occurrence of simultaneous primary adrenal neuroblastoma reflecting multicentric origin of this neoplasm.

A rare case of bilateral stage IV adrenal neuroblastoma with multiple skin metastases in a neonate: Diagnosis, management, and outcome

“…Multifocal NB is extremely rare, [5][6][7] and to the best of our knowledge, there have been no reports about multifocal stage IV neuroblastoma with multiple skin, liver, ocular conjunctiva, and bone marrow metastases in neonate. Multifocal NB is usually associated with favorable biologic features, and patients usually have good prognosis unless there are major associated anomalies such as aganglionosis or Ondine's curse.…”

Bilateral hemorrhagic cystic adrenal neuroblastoma with liver and lymph nodal metastases in an infant

“…[3] Bilateral cystic adrenal neuroblastomas are very rare. Differential diagnosis includes adrenal hemorrhage, abscess, adrenal cytomegaly, dilated upper pole renal calyces etc.…”

Bilateral Adrenal Neuroblastoma

“…7 The other patient with stage IV disease who died received therapy with surgery, chemotherapy, and radiation therapy but died of disease 8 months after diagnosis. 25 The other 2 patients with stage IV disease received therapy with surgery and chemotherapy and one also received a stem cell transplant. 15,31 Both of these patients survived their disease.…”

“…The outcome of patients with bilateral disease correlates with stage of disease and does not seem to be influenced by the presence of bilateral lesions. 24 2 mo IVS (liver) None Died Kramer et al 25 3 mo IV (liver, labia) Surgery, XRT, chemotherapy Died Hann et al 26 5 mo Unknown Unknown Unknown Yoshida et al 27 4 mo IVS (liver) Surgery, XRT, chemotherapy Alive Kameoka et al 28 2 mo IVS (liver, skin marrow)…”