Bilateral Adrenal Masses Due to Histoplasmosis

Mukherjee, J. J.; Villa, Michael; Tan, Lenny; Lee, Kok-Onn

doi:10.1210/jc.2005-1868

Cited by 25 publications

(11 citation statements)

References 4 publications

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“…reported two immunocompetent patients with histoplasmosis who were treatment with oral itraconazole 200 mg daily for 6 months and 18 months respectively. [11] While the adrenal function was normal 9 years after therapy in the first patient, the second patient continued to have enlarged adrenals 18 months after therapy.…”

Section: Discussionmentioning

confidence: 99%

Persistence of histoplasma in adrenals 7 years after antifungal therapy

Kothari¹,

Chopra²,

Bhardwaj³

et al. 2013

Indian J Endocr Metab

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Adrenal histoplasmosis is an uncommon cause for adrenal insufficiency. The duration of treatment for adrenal histoplasmosis is not clear. Existing treatment regimens advocate antifungals given for periods ranging from 6 months to 2 years. We report here a rare case who showed persistence of histoplasma in adrenal biopsy 7 years after being initially treated with itraconazole for 9 months. This calls for a prolonged therapy with regular review of adrenal morphology and histology in these patients.

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Section: Discussionmentioning

confidence: 99%

Persistence of histoplasma in adrenals 7 years after antifungal therapy

Kothari¹,

Chopra²,

Bhardwaj³

et al. 2013

Indian J Endocr Metab

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“…Adrenal involvement is thought to occur in up to 10% of cases but histoplasmosis as a cause of adrenal failure is rare (Ͻ1%), with TB being the most common infective cause (20%). 2,3 As such, there is a justifiably low threshold for considering anti-tuberculous therapy in patients with adrenal failure. However, similarities in presentation and a high mortality associated with untreated disseminated histoplasmosis (between 80% and 100%) make it an important diagnosis to consider despite its relative rarity, especially in patients coming from endemic areas.…”

Section: Discussionmentioning

confidence: 99%

A case of hiccoughs

et al. 2011

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An elderly Asian man returned from Bangladesh with an 18-month history of intermittent hiccoughs, anorexia, weight loss and fever. He had type 2 diabetes on insulin therapy with deteriorating glycaemic control. Examination revealed a thin, pale man, with intermittent hiccoughs, darkening of palmar creases and mucous membranes, angular stomatitis, oral ulceration and mild epigastric tenderness. He appeared clinically dry. He was noted to have a spiking fever to 38.5ЊC and became notably hypotensive with a blood pressure 82/35 mm/Hg during his admission. Initial investigations are shown in Table 1. Chest radiography was unremarkable and an abdominal ultrasound noted a 13.5 cm splenomegaly. There was no evidence for a subphrenic abscess.

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“…Adrenal involvement is usually found in patients with disseminated histoplasmosis. The clinical, pathologic and radiologic presentation is similar to that of tuberculosis with diagnosis confirmed by adrenal gland biopsy [13,14]. In one series, primary adrenal insufficiency was reported in 41% of patients [15].…”

Section: Adrenal Histoplasmosismentioning

confidence: 96%

Unusual Presentations of Adrenal Masses

Kumar¹,

Singh²

2017

Clinical Management of Adrenal Tumors

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With the advancement in imaging technology and pathological evaluation, several unusual adrenal gland lesions have been identified over the years. Presently, the literature consists of case reports or small case series without a comprehensive review on these uncommon adrenal pathologies. The current chapter discusses the epidemiology, pathogenesis, pathology, imaging features and management principles of uncommonly reported infectious and neoplastic adrenal masses.

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Bilateral Adrenal Masses Due to Histoplasmosis

Cited by 25 publications

References 4 publications

Persistence of histoplasma in adrenals 7 years after antifungal therapy

Persistence of histoplasma in adrenals 7 years after antifungal therapy

A case of hiccoughs

Unusual Presentations of Adrenal Masses

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