Bilateral acute retinal necrosis and herpes simplex type 2 encephalitis in a neonate

Sympathetic ophthalmia following severe fungal keratitis

“…21 Finally, there was one case of HSV-2 in a neonate. 22 In our case, the only possible compromising factor was administration of dexamethasone over a 6-day period. However, this was given in addition to aciclovir and might be regarded as a standard part of his encephalitis therapy.…”

“…BARN following HSE could only be found in seven case reports. [17][18][19][20][21][22] The majority of patients in the unilateral ARN group had no other factors which might be associated with impaired host defence. In contrast, the reported cases of BARN following encephalitis all had some associated factors that may have reduced host defence.…”

Impaired Plasmacytoid Dendritic Cell Innate Immune Responses in Patients with Herpes Virus-Associated Acute Retinal Necrosis

“…Two patients (P01, P02) reported severe meningitis and/or encephalitis in early childhood (Table II), reminiscent of perinatal HSV-2 infections which were followed by immediate or delayed necrotic retinitis (49,50). HSV-1 encephalitis preceding ARN was described by our group (36) and others (51)(52)(53)(54).…”

Acute retinal necrosis (ARN) in the context of neonatal HSV-2 exposure and subconjunctival dexamethasone: case report and literature review

“…This is supported by the number of published cases of HSV-2 ARN with neonatal exposure, twice as many of which have been seen in the last decade, compared to those reported in the 1990s. 3,5,6,[9][10][11][12][13][14][15][16][17][18][19][20][21] Although many documented cases of HSV-2 ARN in the literature have a history of neonatal exposure, some patients do not have such histories and the question of how the infection was acquired remains. 21 Grose 21 proposed that neonatal HSV-2 infections may be contracted perinatally as a subclinical skin, eye, or mouth infection.…”