Bilateral acute posterior multifocal placoid pigment epitheliopathy (APMPPE) following SARS-CoV-2 mRNA vaccine

The characteristics of white dot syndromes following COVID-19 Vaccines: a systematic review

“…VF: paracentral scotoma with mean deviation of 5.57 db in the OD. The paracentral scotoma was prominent in the inferior nasal area in the OD, which was corresponding to her flashing lights symptom and the white dots lesion in the fundus imaging MVC COVID-19 Vaccination 1 2 Mild fatigue, and the highest recorded body temperature was 37.5° Celsius Da Silva et al [ 24 ] Detrick et al [ 73 ] Suggestive of AMN in both cases Unremarkable for both cases Case 1: Blood tests: showed reduced neutrophil count and very mild thrombo- cytopenia (141 000/μL – reference values 150–450 000/μL) Vaxzervria 1 NA NA Detrick et al [ 73 ] Diafas Et al [ 48 ] Hyperreflectivity and disruption to the outer retinal layers from outer plexiform layer (OPL) to the RPE in both foveae correlating well-circumscribed lesions with early dense hypofluoroescence, followed by late hyperfluoroescence Serological investigations and a chest X-ray ruled out infectious, autoimmune, and inflammatory aetiologias while MRI of the brain ruled out central nervous system (CNS) vasculitis Pfizer-BioNTech-BioNTech Manufacturing 2 NA NA Diafas Et al [ 48 ] Dumitru [ 49 ] Multifocal highly reflective lesions at the junction of the outer plexiform layer (OPL) and outer nuclear layers (ONL), with disruption of the underlying ellipsoid and interdigitation zones (EZ/IZ) consistent with AMN Subtle macular hypoautofluorescence was observed on the left side Initial laboratory work- up revealed inflammatory syndrome with high-level of C-Reactive protein (54 mg/L) and a leukopenia (2.6 G/L) Platelets were normal (278 G/L). Coagulation screening tests, including prothrombin time and activated partial thromboplastin time were normal.…”