Bilateral acute depigmentation of the iris: a case report

Abstract

Bilateral acute depigmentation of the iris (BADI) is a new clinical entity of unknown etiology and is characterized by bilateral, symmetrical, and simultaneous depigmentation of the iris with focal or diffuse stromal atrophy; this condition generally has a good prognosis. We present a case of a 26-year-old woman who noted a spontaneous change in the iris color in both eyes in the last 2 months. The oph thal mological findings were atrophy of the iris stroma and pigmentation of the trabecular meshwork, without affecting the pigmented epithelium of the iris. Her intraocular pressure was normal and the visual acuity was 20/20 in both eyes.

Causes of Iris Depigmentation in Young and Middle Age. Clinical Example

“…Авторы исследования описывают данное заболевание одновременно у двух братьев и сестер. Кроме генетической имеется предположение об инфекционной природе заболевания [22,23].…”

Commentary: Bilateral acute depigmentation of iris

“…Bilateral acute depigmentation of iris[1] (BADI) is a rare, recently described entity of unknown etiology[2] first characterized in 2006 by Tukal-Tutkun et al . More common in middle-age females it presents asymptomatically with a unique bilateral symmetrical simultaneous depigmentation of iris and consequent focal/diffuse stromal atrophy and pigment dispersion in anterior segment, including the trabecular meshwork.…”

“…More common in middle-age females it presents asymptomatically with a unique bilateral symmetrical simultaneous depigmentation of iris and consequent focal/diffuse stromal atrophy and pigment dispersion in anterior segment, including the trabecular meshwork. What is unique is the iris pigment epithelia rarely goes in for atrophy with no transillumination defects,[3] nil pupillary abnormalities,[3] nil inflammatory parameters,[2] and repigmentation may occur spontaneously. [2]…”

“…What is unique is the iris pigment epithelia rarely goes in for atrophy with no transillumination defects,[3] nil pupillary abnormalities,[3] nil inflammatory parameters,[2] and repigmentation may occur spontaneously. [2]…”

“…With no confirmed causes, the speculated etiologies postulated includes[2] viral etiologies such as cytomegalovirus, herpes simplex, herpes zoster, toxic effects following fumigation therapy,[4] iris ischemia, and neurotrophic mechanisms. Preceded by flu-like illness, upper respiratory tract infections, oral moxifloxacin [sans topical moxifloxacin], increase in intraocular pressure (IOP) may occur with sparse inflammatory indices.…”