Bilateral acute angle-closure glaucoma induced by duloxetine

Atum, Mahmut; Tunc, Vildan; Demiryurek, Enes; Alagöz, Gürsoy

doi:10.18071/isz.70.0358

Cited by 10 publications

(5 citation statements)

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“…SSRI agents have been reported to increase the intraocular pressure in another review, but this did not require discontinuation of the drugs and only required follow-up by the Ophthalmology team [9]. However, some case reports have indicated that SNRIs such as Duloxetine [2,10] and Venlafaxine [11,12], and SSRIs such as sertraline [13], paroxetine [14], and citalopram [15] can cause angle-closure glaucoma. The reason is reported in these studies as the serotonin receptors in the iris, cornea, and ciliary body.…”

Section: Review Of the Baseline And 3rd Month Results Of The Patients...mentioning

confidence: 99%

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Evaluation of the effects of duloxetine treatment on anterior segment parameters by optical coherence tomography

et al. 2022

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Purpose: To evaluate the effects of Duloxetine on anterior segment parameters and intraocular pressure(IOP) in open angle eyes. Methods: 38 eyes of 38 patients with bromyalgia who had open or wide open angles according to the Shaffer classi cation. Anterior segment optic coherence tomography was performed before and after (month 3) Duloxetine treatment. IOP, central corneal thickness(CCT), corneal endothelial cell density(CECD) and anterior chamber depth(ACD) were also recorded and evaluated.Results: No statistically signi cant difference was determined in IOP, CCT and CECD(p > 0.05). However, a statistically signi cant increase was determined in both the temporal and nasal anterior chamber angle, angle opening distance, nasal trabecular-iris space area and ACD values between the baseline and month 3 (p < 0.001). Conclusion:We think that the short term use of Duloxetine does not lead to clinically signi cant changes despite their statistically signi cant effects on the anterior chamber parameters.

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Section: Review Of the Baseline And 3rd Month Results Of The Patients...mentioning

confidence: 99%

“…[1]. Some studies in the literature have reported that duloxetine [2,3] and Selective Serotonin Reuptake Inhibitors (SSRI) [4][5][6] may lead to angle-closure glaucoma. However, these have been in the form of case reports or case series.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effects of duloxetine treatment on anterior segment parameters by optical coherence tomography

et al. 2022

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“…Firstly, the causative relationship might be overestimated, considering that psychiatric disorders could be secondary to the glaucoma diagnosis even secondary to the use of antiglaucoma medication. Secondly, some antidepressants such as topiramate ( Kocamaz and Karadag, 2019 ), aripiprazole ( Shen et al, 2018 ), milnacipran ( Keks et al, 2018 ), and duloxetine ( Mahmut et al, 2017 ) have potential eye side effects, such as acute onset angle-closure glaucoma. Chen et al (2016) found that patients using selective serotonin reuptake inhibitors (SSRIs) have a 5.80-fold increased risk of angle-closure glaucoma in a week.…”

Section: Discussionmentioning

confidence: 99%

Mendelian randomization study shows no causal relationship between psychiatric disorders and glaucoma in European and East Asian populations

Zhang,

Fu,

Feng

et al. 2024

Front. Genet.

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Background: Glaucoma is a leading cause of blindness strongly associated with psychiatric disorders, but the causal association between glaucoma and psychiatric disorders remains uncertain because of the susceptibility of observational studies to confounding and reverse causation. This study aims to explore the potential causal association between glaucoma and three highly related psychiatric disorders (Depression, Insomnia, and Schizophrenia) in the European and East Asian populations using a two-sample Mendelian randomization analysis.Methods: Instrumental variables (IVs) of depression, insomnia, and schizophrenia in the European population were obtained after strict filtering. Summary-level data for glaucoma and glaucoma subtypes (primary open-angle glaucoma and primary closed-angle glaucoma) were obtained as outcomes. The inverse variance weighting (IVW) method was used as the primary method. Additionally, the causal effect was evaluated in the East Asian population using the same methods to validate analysis results. The robustness of these results was confirmed using heterogeneity, pleiotropy, and Steiger directionality test.Results: The primary MR results indicated that genetically driven psychiatric disorders were not causally associated with glaucoma (Depression: odds ratio (OR): 1.15, 95% confidence interval (CI): 0.93–1.42, p = 0.20; Insomnia: OR: 1.14, 95% CI: 0.63–2.05, p = 0.66; Schizophrenia: OR: 1.00, 95% CI: 0.93–1.08, p = 0.95), either with the risk of glaucoma subtypes in the European population. Meanwhile, results in the East Asian population were consistent with the results among the European population (Depression: OR = 1.38, CI 0.75–2.53, p = 0.30; Insomnia: OR = 0.99, CI 0.83–1.18, p = 0.93; Schizophrenia: OR = 1.06, CI 0.94–1.20, p = 0.34) with similar causal estimates in direction. Consistency was obtained by corroborating with other supporting methods. Besides, the robustness of the results was proved and the directionality test confirmed our estimation of potential causal direction (p < 0.001).Conclusion: This study found a non-causal association between psychiatric disorders and the risk of glaucoma in the European and East Asian populations, which contradicts many existing observational reports, indicating that increased psychiatric disorders in glaucoma patients were more likely modifiable rather not inheritable.

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“…The effect of lowering IOP is good, but the incidence of postoperative complications is high (26). OCT can directly image the lens, the measured lens thickness, and the relative position of the lens more objectively (27).…”

Section: Discussionmentioning

confidence: 99%

A system review and meta-analysis of the treatment of acute angle-closure glaucoma under optical coherence tomography

Chen

Peng

2021

Ann Palliat Med

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Background: A meta-analysis was conducted to investigate the value of treatment-related indicators of acute angle-closure glaucoma (AACG) based on optical coherence tomography (OCT) to evaluate the curative effect.Methods: Articles on the treatment of AACG in clinical research of OCT published from January 2010 to June 2020 were retrieved from the PubMed, Web of Science, and Spring databases. RevMan 5.3 software was used for the meta-analysis of the relevant data. The angle opening distance (AOD), trabecular-iris space area (TISA), angle recess area (ARA), anterior chamber depth (ACD), anterior chamber width (ACW), anterior chamber area (ACA), anterior chamber volume (ACV), lens vault (LV), iris thickness 750 (IT750), intraocular pressure (IOP), and pupil diameter (PD) values were observed and compared before and after the treatment.Results: A total of 12 articles were included in the meta-analysis. The results indicated that patients' ACD, I-Area, IOP, and PD values were lower after treatment than before treatment [mean deviation (MD):

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Bilateral acute angle-closure glaucoma induced by duloxetine

Cited by 10 publications

References 0 publications

Evaluation of the effects of duloxetine treatment on anterior segment parameters by optical coherence tomography

Evaluation of the effects of duloxetine treatment on anterior segment parameters by optical coherence tomography

Mendelian randomization study shows no causal relationship between psychiatric disorders and glaucoma in European and East Asian populations

A system review and meta-analysis of the treatment of acute angle-closure glaucoma under optical coherence tomography

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