BILAG-2004 index captures systemic lupus erythematosus disease activity better than SLEDAI-2000

Yee, Chee-Seng; Isenberg, David; Prabu, Athiveeraramapandian; Sokoll, K; Teh, Lee‐Suan; Rahman, Anisur; Bruce, Ian N.; Griffiths, Bridget; Akil, Mohammed; McHugh, Neil; D’Cruz, David; Khamashta, Munther A.; Maddison, Peter J.; Zoma, Asad; Gordon, Caroline

doi:10.1136/ard.2007.070847

Cited by 55 publications

(46 citation statements)

References 12 publications

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“…It is noteworthy that, in clinical practice, it is difficult in most cases of lupus nephritis to evaluate disease activity using only the established criteria. 21,22 Doubt is particularly common because criteria such as hematuria and proteinuria may not always reflect the real presence and intensity of glomerular damage or even translate into renal disease activity. Here an additional urinary biomarker would be useful.…”

Section: Discussionmentioning

confidence: 99%

Is there a role for urinary podocyte excretion assessment in lupus nephritis?

et al. 2016

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Objective To establish the occurrence and intensity of podocyturia and its relation to grade of disease activity, as defined by clinical and laboratory criteria. Methods Prospective, cross-sectional study involving 50 patients with lupus nephritis and 29 controls, which had podocyturia levels determined from random urine samples using an immunofluorescence technique. Disease activity was graded by BILAG (renal criteria) and an additional system used in the service (S2). Results Fifty patients with lupus nephritis (WHO classes III, IV and V), with a median age of 37 years, were evaluated. Of these, 86.5% were female, and 52% were BILAG A. Podocyturia quantification in the lupus nephritis and control groups differed significantly (p ¼ 0.009). This score was higher in relation to classes III, IV and V. The correlation with C3 consumption was stronger (p ¼ 0.011) than with C4. The highest levels were found in the most active groups (A and B of BILAG and S2). Lower podocyturia correlated with a lower dose of prednisone. There was no association with the intensity of proteinuria, hematuria or pyuria, serum creatinine levels, among others. Conclusions Podocyturia assessment, which was performed by immunofluorescence in this study, can be used as an indicator of disease activity with the advantage of being a urinary biomarker. The levels proved to be higher in patients with lupus nephritis than in the controls and were particularly higher in class IV. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Is there a role for urinary podocyte excretion assessment in lupus nephritis?

et al. 2016

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“…Skor SLEDAI juga sensitif terhadap perubahan aktivitas penyakit. [8][9][10][11][12][13] Pemantauan skor SLEDAI dapat dilakukan setiap 3-6 bulan atau ketika terdapat perubahan aktivitas penyakit. 1 Penelitian pada pasien LES dewasa yang dilakukan Ibanez dkk, 14 ) dan mengalami penurunan pada pengamatan bulan berikutnya.…”

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Penilaian Aktivitas Penyakit Lupus Eritematosus Sistemik dengan Skor SLEDAI di Departemen Ilmu Kesehatan Anak RSCM

Saleh

Kurniati

Syarif

2016

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Latar belakang. Keberhasilan tata laksana penyakit lupus eritematosus sistemik (LES) memerlukanpemantauan tertentu. Skor systemic lupus erythematosus disease activity index (SLEDAI) adalah alat ukuryang dapat digunakan untuk tata laksana sehari-hari. Saat ini belum ada data mengenai pemantauan aktivitaspenyakit LES anak menggunakan skor SLEDAI dengan rentang waktu tertentu.Tujuan. Memantau aktivitas penyakit LES anak dengan skor SLEDAI setiap 3 bulan selama satu tahunpengamatan.Metode. Studi deskriptif retrospektif menggunakan data rekam medik dari 01 Juli 2005 sampai dengan31 Juli 2013.Hasil. Tigapuluh rekam medik memenuhi kriteria penelitian. Manifestasi awal tersering berdasarkan skorSLEDAI adalah artritis, rash, demam, peningkatan dsDNA, dan komplemen darah rendah. Perubahan skorSLEDAI terutama terlihat pada pengamatan antara bulan ke-0 dengan bulan ke-3. Pada awal pengamatan,mayoritas pasien termasuk high activity, tetapi pada akhir pengamatan menjadi no activity.Kesimpulan. Penilaian skor SLEDAI setiap 3 bulan dapat digunakan untuk memantau aktivitas penyakitLES anak.

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“…In a subsequent study, it was shown that the BILAG-2004 index captures disease activity better than SLEDAI-2000. 13 In conclusion, although the title of this editorial highlights the multiplicity of disease activity indices available for the assessment of lupus patients, it must be borne in mind that these tools are a considerable advance on what was available prior to the mid-1980s. Furthermore, in the last three years the updated versions of SLEDAI, SLEDAI-2000 and BILAG, BILAG-2004 are likely to become, by far, the most widely used indices, but how they perform in the ongoing clinical trials will be critical in determining their long-term usage.…”

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confidence: 99%

BILAG, SLEDAI, SIS, ECLAM, WAM, SLAM …. Thank you MAM

Isenberg

2007

Lupus

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BILAG-2004 index captures systemic lupus erythematosus disease activity better than SLEDAI-2000

Cited by 55 publications

References 12 publications

Is there a role for urinary podocyte excretion assessment in lupus nephritis?

Is there a role for urinary podocyte excretion assessment in lupus nephritis?

Penilaian Aktivitas Penyakit Lupus Eritematosus Sistemik dengan Skor SLEDAI di Departemen Ilmu Kesehatan Anak RSCM

BILAG, SLEDAI, SIS, ECLAM, WAM, SLAM …. Thank you MAM

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