BIiochemical Markers in Pregnancy Associated with Sj�gren�s Syndrome and Thrombophilia

Abstract

Sj�gren�s syndrome (SS) is a multisystemic disease mainly characterized by the hypofunction of the lachrymal and salivary glands and can be either primary or secondary, when related to other autoimmune pathologies. We present the case of a 35-year-old female admitted in the Department of Obstetrics and Gynecology for pregnancy monitoring. The patient had a personal history of a spontaneous abortion one year prior to admission at 5 months of gestation and a maternal history of SS. A multidisciplinary approach with solid obstetrical, rheumatological and neonatal monitoring is essential for best outcomes of the mother and fetus. An early detection of maternal and fetal immune-mediated threats and judicious use of medication is essential in women with autoimmune diseases who plan conceiving.

Umbilical cord lactate compared with pH as predictors of intrapartum asphyxia

“…Perinatal hypoxia is difficult to predict and avoid, as it can be the result of fetal malformations, prematurity, labor dystocia or unexpected events such as retroplacental hematoma (14,15). In addition, in some cases even less severe pathologies such as thrombophilia can be an important risk factor for perinatal hypoxic events (16)(17)(18). Thus, an objective mean of assessing fetal hypoxia is important for confirming or excluding intrapartum asphyxia and predicting neonatal long term morbidity and mortality (19,20).…”

Determining an Umbilical Cord pH Cutoff Value for Predicting Neonatal Morbidity Related to Intrapartum Hypoxia

“…Intrapartum hypoxia can have multiple causes starting with prematurity and distocic labor going to serious accidents such as retroplacental hematoma [11,12]. Umbilical cord gases are used to evaluate a newborn's acid-base status and the presence of hypoxia in acute and chronic fetal distress various etiologies [13].…”