Bihemispheric ischemic strokes in patients with COVID-19

Kurian, Christeena; Mayer, Stephan A.; Kaur, Gurmeen; Sahni, Ramandeep; Samaan, Mena; Viswanathan, Divya; Sami, Tamarah; Ali, Syed Atif; Alshammari, Hussein; Bloomfield, Jessica; Bravo, M. I. S.; Nuoman, Rolla; Gulko, Edwin; Gandhi, Chirag D.; Al‐Mufti, Fawaz

doi:10.1016/j.jns.2021.119901

Cited by 5 publications

(5 citation statements)

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“…They reported in detail 5 cases of bihemispheric ischemic stroke associated with COVID-19 infection; the patients were under 70 years of age, had elevated D-dimer, ferritin, and interleukin-6, and showed severe viral inflammation and hypercoagulability. [ 4 ] We also reported a case of cerebral infarction in the insular cortex after the COVID-19 conventional strain pneumonia. [ 5 ] In a multivariate analysis controlling for race and ethnicity, COVID-19 infection is significantly and independently associated with large vessel occlusive stroke, with an odds ratio of 2.4.…”

Section: Discussionmentioning

confidence: 99%

Beware of bihemispheric stroke after Omicron variant infection in the elderly

Nagamine¹

2023

Brain Circ

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Section: Discussionmentioning

confidence: 99%

Beware of bihemispheric stroke after Omicron variant infection in the elderly

Nagamine¹

2023

Brain Circ

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“…The COVID-19 pandemic brought on by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had and will continue to impact human life world significantly [168,169]. The incidence of complications, such as acute respiratory distress syndrome, septic shock, and ischemic stroke, is more significant in infected patients undergoing emergency surgery [162].…”

Section: Potential Implication Of Covid-19 In Pocdmentioning

confidence: 99%

Bridging the Gap: Investigating the Link between Inflammasomes and Postoperative Cognitive Dysfunction

Zhang¹,

Liu²,

Sun³

et al. 2023

Aging and disease

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Postoperative cognitive dysfunction (POCD) is a cluster of cognitive problems that may arise after surgery. POCD symptoms include memory loss, focus inattention, and communication difficulties. Inflammasomes, intracellular multiprotein complexes that control inflammation, may have a significant role in the development of POCD. It has been postulated that the NLRP3 inflammasome promotes cognitive impairment by triggering the inflammatory response in the brain. Nevertheless, there are many gaps in the current literature to understand the underlying pathophysiological mechanisms and develop future therapy. This review article underlines the limits of our current knowledge about the NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome and POCD. We first discuss inflammasomes and their types, structures, and functions, then summarize recent evidence of the NLRP3 inflammasome's involvement in POCD. Next, we propose a hypothesis that suggests the involvement of inflammasomes in multiple organs, including local surgical sites, blood circulation, and other peripheral organs, leading to systemic inflammation and subsequent neuronal dysfunction in the brain, resulting in POCD. Research directions are then discussed, including analyses of inflammasomes in more clinical POCD animal models and clinical trials, studies of inflammasome types that are involved in POCD, and investigations into whether inflammasomes occur at the surgical site, in circulating blood, and in peripheral organs. Finally, we discuss the potential benefits of using new technologies and approaches to study inflammasomes in POCD. A thorough investigation of inflammasomes in POCD might substantially affect clinical practice.

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“…During the COVID-19 pandemic, multiple strokes occurred in many elderly people (Nagamine, 2023). Stroke after COVID-19 is characterized by abnormal microvascular circulation and microthrombus formation, leading to multifocal lesions (Kurian et al, 2022). The increase in multifocal cerebral infarcts due to COVID-19 infection may have increased the formation of right-sided predominantly multifocal lesions, as in this patient, resulting in increased secondary mania during the COVID-19 pandemic.…”

Section: Typical Case Presentationmentioning

confidence: 99%

Poststroke Mania During the COVID-19 Pandemic

Nagamine

2023

J Nerv Ment Dis

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The pandemic of coronavirus infection 2019 (COVID-19) is stressing people's daily lives and making them more susceptible to various mental illnesses. Depression and suicide attempt as well as, strangely enough, manic patients are on the rise. The main complication of COVID-19 infection is ischemic stroke. Multiple lacunar infarcts in the white matter of the right middle cerebral artery region induce an imbalance of blood flow in the left and right cerebral cortex and risk causing mania. The increase in mania during the COVID-19 must be considered not only a primary increase due to stress but also poststroke mania secondary to COVID-19 infection.

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Bihemispheric ischemic strokes in patients with COVID-19

Cited by 5 publications

References 0 publications

Beware of bihemispheric stroke after Omicron variant infection in the elderly

Beware of bihemispheric stroke after Omicron variant infection in the elderly

Bridging the Gap: Investigating the Link between Inflammasomes and Postoperative Cognitive Dysfunction

Poststroke Mania During the COVID-19 Pandemic

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