Bihemispheric developmental alterations in basal ganglia volumes following unilateral perinatal stroke

Hassett, Jordan; Carlson, Helen L.; Babwani, Ali; Kirton, Adam

doi:10.1016/j.nicl.2022.103143

Cited by 6 publications

(11 citation statements)

References 55 publications

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“…Regarding volumes, we observe a decrease in the volume of structures in the lesioned hemisphere of NAIS participants, which confirms the results of previous studies ( Hassett et al, 2022 ); ( Ilves et al, 2022 ). Additionally, there appears to be a slight increase in volumes in the contra-lesional hemisphere, as already reported in studies of the contra-lesional thalamus after perinatal stroke ( Craig et al, 2019 ).…”

Section: Resultssupporting

confidence: 91%

“…Then, we could discuss the limited sample size. Nevertheless, our study cohort is comparable in size to other studies investigating NAIS ( Hassett et al, 2022 ); ( Lee et al, 2005 ) and was already considered for previous work ( Al Harrach et al, 2019 , Al Harrach et al, 2021 ); ( Dinomais et al, 2016 ). Moreover, this is a unique homogeneous cohort in terms of patients’ characteristics (term newborns aged 7 years), lesion characteristics (precise timing of the injury in the neonatal period, infarct localization in the MCA territory), and imaging conditions (monocentric data acquisition using a 3 T MRI scanner).…”

Section: Discussionmentioning

confidence: 51%

“…Direct damage to the basal ganglia and/or thalamus typically does not occur in NAIS in the MCA territory, even if in cases of proximal M1 occlusion, damage to the basal ganglia can occur. Additionally, long-term direct or indirect structural alterations of these structures have been described in both hemispheres following NAIS ( Craig et al, 2019 , Hassett et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…Accurately predicting hand motor function in both the affected and ‘unaffected’ hands from morphometric MRI remains a complex task. Indeed, many studies have provided conflicting or sparse results ( Dinomais et al, 2016 , Craig et al, 2019 , Hassett et al, 2022 , Ilves et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…Craig et al ( Craig et al, 2019 ) did not find this association for the thalamus. Interestingly, Hasset et al ( Hassett et al, 2022 ) also found an association between the volume of the ipsilesional putamen and affected hand function, without analyzing the volume of the thalamus, yet closely linked to basal ganglia in brain motor function.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Hand function after neonatal stroke: A graph model based on basal ganglia and thalami structure

Coupeau,

Démas,

Fasquel

et al. 2024

NeuroImage: Clinical

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Section: Resultssupporting

confidence: 91%

Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hand function after neonatal stroke: A graph model based on basal ganglia and thalami structure

Coupeau,

Démas,

Fasquel

et al. 2024

NeuroImage: Clinical

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Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke

Shinde

Craig

Hassett

et al. 2023

Sci Rep

Self Cite

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Perinatal stroke causes most hemiparetic cerebral palsy and cognitive dysfunction may co-occur. Compensatory developmental changes in the intact contralesional hemisphere may mediate residual function and represent targets for neuromodulation. We used morphometry to explore cortical thickness, grey matter volume, gyrification, and sulcal depth of the contralesional hemisphere in children, adolescents, and young adults after perinatal stroke and explored associations with motor, attention, and executive function. Participants aged 6–20 years (N = 109, 63% male) with unilateral perinatal stroke underwent T1-weighted imaging. Participants had arterial ischemic stroke (AIS; n = 36), periventricular venous infarction (PVI; n = 37) or were controls (n = 36). Morphometry was performed using the Computational Anatomy Toolbox (CAT12). Group differences and associations with motor and executive function (in a smaller subsample) were assessed. Group comparisons revealed areas of lower cortical thickness in contralesional hemispheres in both AIS and PVI and greater gyrification in AIS compared to controls. Areas of greater grey matter volume and sulcal depth were also seen for AIS. The PVI group showed lower grey matter volume in cingulate cortex and less volume in precuneus relative to controls. No associations were found between morphometry metrics, motor, attention, and executive function. Cortical structure of the intact contralesional hemisphere is altered after perinatal stroke. Alterations in contralesional cortical morphometry shown in perinatal stroke may be associated with different mechanisms of damage or timing of early injury. Further investigations with larger samples are required to more thoroughly explore associations with motor and cognitive function.

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Ultra-low-field paediatric MRI in low- and middle-income countries: super-resolution using a multi-orientation U-Net

Baljer,

Zhang,

Bourke

et al. 2024

Preprint

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PurposeOwing to the high cost of modern MRI systems, their use in clinical care and neurodevelopmental research is limited to hospitals and universities in high income countries. Ultra-low-field systems with significantly lower scanning costs bear the potential for global adoption, however their reduced SNR compared to 1.5 or 3T systems limits their applicability for research and clinical use.MethodsIn this paper, we describe a deep-learning based super-resolution approach to generate high-resolution isotropic T2-weighted scans from low-resolution inputs. We train a ‘multi-orientation U-Net’, which uses multiple low-resolution anisotropic images acquired in orthogonal orientations to construct a super-resolved output.ResultsOur approach exhibits improved quality of outputs compared to current state-of-the-art methods for super-resolution of ultra-low-field scans in paediatric populations. The average correlation value between volume estimates from high-field scans and super-resolved outputs rises to 0.77 using our method, compared to 0.71 using earlier techniques.ConclusionOur research serves as proof-of-principle of the viability of training deep-learning based super-resolution models for use in neurodevelopmental research and presents the first U-Net trained exclusively on paired ultra-low-field and high-field data from infants.

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Bihemispheric developmental alterations in basal ganglia volumes following unilateral perinatal stroke

Cited by 6 publications

References 55 publications

Hand function after neonatal stroke: A graph model based on basal ganglia and thalami structure

Hand function after neonatal stroke: A graph model based on basal ganglia and thalami structure

Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke

Ultra-low-field paediatric MRI in low- and middle-income countries: super-resolution using a multi-orientation U-Net

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