Biglycan expression in hypertensive subjects with normal or increased carotid intima-media wall thickness

Sardo, M.A.; Mandraffino, Giuseppe; Campo, Salvatore; Saitta, Carlo; Bitto, Alessandra; Alibrandi, Angela; Riggio, Stefania; Imbalzano, Egidio; Saitta, Antonino

doi:10.1016/j.cca.2009.05.024

Cited by 25 publications

(14 citation statements)

References 41 publications

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“…5,6 Some reports 3,4,7 have shown a significant association between inflammatory markers and elevated BP, consistent with our findings. Kim et al 8 reported that TNF-a level correlated with the BP index and IL-6 level correlated with the BP variability index, implying that inflammation may be a mediator for the link between BP variability and target organ damage.…”

Section: Discussionsupporting

confidence: 92%

Correlation of tumor necrosis factor alpha and interleukin 6 with hypertensive renal damage

Yang

2010

Renal Failure

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Background: Many efforts have been made to investigate the role played by cytokines in the development of hypertension. But few reports exist on the association between cytokines and hypertensive renal damage. This study was to observe the changes of the serum levels of cytokines, tumor necrosis factor alpha (TNF-a), and interleukin 6 (IL-6) in patients with hypertensive renal damage, whereby to study the correlation of TNF-a and IL-6 with the hypertensive renal damage. Methods: According to their urinary albumin excretion rate (UAER), 102 patients with essential hypertension were divided into three groups: normoalbuminuria hypertensive group (n = 37), microalbuminuria hypertensive group (n = 36), and proteinuric hypertensive group (n = 29). Serum TNF-a and IL-6 of all subjects were measured with radioimmune assay. Thirty age-and gendermatched normotensive persons were selected as normotensive control group. Results: Serum levels of TNF-a and IL-6 were significantly higher in patients with essential hypertension than those in normotensive control group (p < 0.5). Serum levels of TNF-a and IL-6 increased in proportion to UAER. The statistical significance was present among groups (p < 0.05). Both TNF-a and IL-6 were found to have a positive correlation with UAER (r = 0.79, p < 0.01; r = 0.75, p < 0.01), but not with the levels of blood pressure (BP). Conclusions: TNF-a and IL-6 are remarkably increased in hypertensive patients and may play an important role in the pathogenesis and the development of hypertensive renal damage.

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Section: Discussionsupporting

confidence: 92%

Correlation of tumor necrosis factor alpha and interleukin 6 with hypertensive renal damage

Yang

2010

Renal Failure

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“…15 Previously, we investigated the expression of BGN in circulating monocytes isolated from patients with essential hypertension. 17 We found an inflammatory pattern in these hypertensive patients, including elevated levels of interleukin (IL)-6, tumour necrosis factor (TNF)-a and C-reactive protein (CRP). In addition, increased BGN mRNA and protein expression was found in monocytes from these patients, which was associated with inflammatory markers, thus suggesting a role for BGN in inflammation and hypertension.…”

Section: Introductionmentioning

confidence: 96%

“…Previously, we investigated the expression of BGN in circulating monocytes isolated from patients with essential hypertension 17 . We found an inflammatory pattern in these hypertensive patients, including elevated levels of interleukin (IL)‐6, tumour necrosis factor (TNF)‐α and C‐reactive protein (CRP).…”

Section: Introductionmentioning

confidence: 99%

“…Beyond its classic role in influencing several biological processes, [21][22][23] AngII may act as a pro-inflammatory molecule, enhancing the expression of various factors in the inflammatory cascade. [24][25][26][27][28][29][30] Molecular studies may enable characterization of the role of AngII in mechanisms underlying vascular inflammation and atherosclerosis; therefore, in a previous study, we investigated whether AngII can induce BGN expression in blood monocyte cells 17 and found that the in vitro addition of AngII to peripheral blood monocytes stimulated the synthesis of BGN mRNA, particularly in hypertensive patients.…”

Section: Introductionmentioning

confidence: 99%

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Effects of the angiotensin II receptor blocker losartan on the monocyte expression of biglycan in hypertensive patients

Sardo¹,

Mandraffino²,

Riggio³

et al. 2010

Clin Exp Pharma Physio

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1. Recently, we demonstrated that biglycan (BGN) is increased in circulating monocyte cells from hypertensive patients and that angiotensin (Ang) II is able to increase BGN expression. The present study was designed to investigate the effects of treatment with the angiotensin AT(1) receptor antagonist losartan on monocyte BGN mRNA and protein expression in essential hypertension. 2. One hundred and twenty-six newly diagnosed hypertensive patients without additional risk factors for atherosclerosis and cardiovascular disease were treated with 100 mg losartan once daily for 6 months. Biglycan mRNA and protein expression was determined in monocytes isolated from peripheral blood before (T(0)) and after (T(1)) therapy. Plasma levels of interleukin (IL)-6, tumour necrosis factor (TNF)-alpha and high sensitivity C-reactive protein (hs-CRP) were also determined. In addition, BGN mRNA and protein expression was determined after the ex vivo addition of 1 micromol/L AngII to monocytes isolated from 20 randomly selected hypertensive patients. 3. Biglycan mRNA and protein expression, blood pressure and plasma levels of fibrinogen, IL-6, TNF-alpha and CRP were significantly lower at T(1) than at T(0). Variations in BGN expression were associated with inflammatory markers, but not directly with blood pressure. In AngII-stimulated monocytes, BGN mRNA and protein expression was significantly lower at T(1) that at T(0). Moreover, mean BGN mRNA expression in AngII-stimulated monocytes isolated from losartan-treated patients was similar to baseline expression in unstimulated monocytes from untreated patients. 4. The results of the present study show that losartan can reduce BGN expression in monocytes from hypertensive patients, without any linear association with blood pressure, suggesting that the effects of AngII on BGN expression in monocytes may be modulated, in part, by an AT(1) receptor blocker.

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“…This report describes a case of CAF to the right ventricle (RV) resulting in severe pulmonary hypertension, in a patient with end-stage renal disease (ESRD) on hemodialysis and rheumatoid arthritis [2]. The patient had a history of hypertension for over 30 years [3]. Computed tomographic pulmonary angiography ruled out pulmonary embolism, but it suggested a coronary fistula to the RV cavity.…”

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confidence: 99%

Left coronary artery fistula to right ventricle complicated heart failure in a patient on hemodialysis

et al. 2013

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Coronary artery fistulas (CAF) are rare, and are most often diagnosed by echocardiography or by coronary angiography. The incidence of this disease is very low, with a more frequent occurrence of fistulas originating in the right coronary artery. There is a higher incidence of CAF to right heart chambers, with CAF to the left ventricle (LV) being rare. Treatment can be surgical or percutaneous [1]. This report describes a case of CAF to the right ventricle (RV) resulting in severe pulmonary hypertension, in a patient with end-stage renal disease (ESRD) on hemodialysis and rheumatoid arthritis [2]. The patient had a history of hypertension for over 30 years [3]. Computed tomographic pulmonary angiography ruled out pulmonary embolism, but it suggested a coronary fistula to the RV cavity.A 61-year-old woman was referred for cardiac evaluation for chest pain and worsening dyspnea. The patient was on maintenance hemodialysis for the prior 2 years owing to ESRD. Clinical examination revealed tachycardia, crackles at both bases with no wheezes, rhonchi, or other adventitious sounds, a blood pressure of 160/70 mmHg. The patient had a radio-cephalic fistula constructed at the left wrist between the radial artery and the cephalic vein, using end-to-end anastomosis. An electrocardiogram showed evidence of a right bundle branch block, and signs of ventricular overload. Cross-sectional echocardiography with Doppler interrogation revealed a left ventricular ejection fraction of 55 %, and there was evidence of diastolic dysfunction, without important calcification or regurgitation of the valves.The right atrium and ventricle were dilatated ( Fig. 1a) with an abnormal flow jet pointed to the RV (Fig. 1b), and evidence of severe systolic pulmonary hypertension (PHT) (Fig. 1c) estimated to be 80 mmHg on continuous wave Doppler. There was moderate tricuspid regurgitation with RV function moderately depressed (tricuspid anular plane systolic excursion: 13 mm) [4]. To obtain precise information on the cause of the PHT, a 64-slice multidetector computed tomography (MDCT) was performed. MDCT confirmed right heart dilatation and revealed a CAF connecting the anterior descending artery to the RV cavity without any evidence of pulmonary thromboembolism (Fig. 1d). A coronary angiography showed an enlarged and tortuous aneurysm with a CAF (Fig. 1e) that protruded into the RV, with immediate closure percutaneous with a detachable helical coil (Fig. 1f). We doubt that it was a secondary form, manifested as a result of treatment of hemodialysis causing right heart failure.

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Biglycan expression in hypertensive subjects with normal or increased carotid intima-media wall thickness

Cited by 25 publications

References 41 publications

Correlation of tumor necrosis factor alpha and interleukin 6 with hypertensive renal damage

Correlation of tumor necrosis factor alpha and interleukin 6 with hypertensive renal damage

Effects of the angiotensin II receptor blocker losartan on the monocyte expression of biglycan in hypertensive patients

Left coronary artery fistula to right ventricle complicated heart failure in a patient on hemodialysis

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