“…We fully agree with the comments from Palamuthusingam and colleagues. 1 As we have pointed out in the last paragraph of our review article, 2 Any larger data acquisition endeavor will face current big data problems that include not only infrastructure but also ethical issues. This challenge holds for all kinds of data, in particular EHRs [electronic health records], for which regulating access, sharing, and the balance of commercial value versus open data is important.…”