The health, wellness and adaptation response of astronauts during spaceflight is a key component for the success of any manned mission. Physiological and psychological responses of astronauts during spaceflight have been monitored from the first manned missions sixty years ago. However, limited communication networks to and within the spacecraft have limited methods to monitor the health, wellness and adaptation response of astronauts in real-time. This has resulted in a paradigm of astronaut monitoring as discontinuous samplings of physiological data that are captured on board the spacecraft and transported to Earth on storage devices for retrospective down sampled analysis. In 2009, as part of prior research, McGregor proposed a big data analytics framework and platform, that enables the capture and processing of physiological data and other clinical data in real-time for new approaches to real-time health monitoring. The platform, was named the Artemis platform after the Greek goddess of childbearing as the first domain it was used was neonatal intensive care. Its efficacy and reliability as a new approach for real-time health monitoring has been demonstrated in the critical care domain and specifically within the domain of neonatal intensive care. McGregor previously proposed the application of Artemis as an approach for autonomous health monitoring within the spacecraft to support missions within and beyond low Earth orbit. This would enable sophisticated realtime health, wellness and adaptation assessment that did not require the transmission of data beyond the spacecraft. Artemis Cloud has been proposed as a cloud-based approach to provide remote health monitoring. Artemis Cloud enables Health Analytics as a Service and has been demonstrated utilizing the Ontario Research and Innovation Optical Network (ORION) in Ontario and Artemis Cloud instances located at the Compute Ontario advanced research computing node within the Centre for Advanced Computing, Queen's University, Ontario providing remote health monitoring of neonatal intensive care patients at two hospitals in Ontario, Canada.There is great potential for this Health Analytics as a Service model enabled through Artemis Cloud to support the assessment of health, wellness and adaptation response of astronauts in space, however, robust and reliable networks are required. The next stage of space exploration will see unmanned missions using robots that will require prognostics and health management. This will be followed by manned lunar orbiters, Moon bases and Mars missions that will all require the support of health, wellness and adaptation assessment of astronauts engaged in those missions. Deep space hybrid radio frequency and optical networks have great potential to address the current gap in space communication networks. This paper presents a framework and infrastructure to enable real-time equipment monitoring for prognostics and health management and astronaut health monitoring through cloud-based Health Analytics as a Service utilizing space da...