Bifurcation analysis of a tuberculosis progression model for drug target identification
Eliezer Flores-Garza,
Rogelio Hernández-Pando,
Ibrahim García-Zárate
et al.
Abstract:Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. The emergence and rapid spread of drug-resistant M. tuberculosis strains urge us to develop novel treatments. Experimental trials are constrained by laboratory capacity, insufficient funds, low number of laboratory animals and obsolete technology. Systems-level approaches to quantitatively study TB can overcome these limitations. Previously, we proposed a mathematical model describing the key regulatory mechanisms underlying the pathologi… Show more
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