Bifurandione. II. Hydrogenation

Holmquist, H. E.; Marsh, F. D.; Sauer, J. C.; Engelhardt, V. A.

doi:10.1021/ja01523a047

Cited by 7 publications

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“…Noncommercial epoxides tested in this work were made by the standard method from the corresponding olefins and m -CPBA. Specimens for the comparison of noncommercial vic -diols and α-ketols involved in this work as well as of δ-acetoxypentanoic acid, 4-oxooctanedioic acid, 4-hydroxyoctanedioic acid γ-lactone, and 1,4-cyclooctanedione were prepared according to literature procedures. Specimens of 1-hydroperoxy-2-octanol ( 5IIa ) and -decanol ( 5IIb ) free of the respective regioisomer I were prepared from the corresponding epoxides and alkaline hydrogen peroxide adapting the procedure described in the literature 26 for analogous 1-hydroperoxy-2-hydroxy derivatives.…”

Section: Methodsmentioning

confidence: 99%

Efficient Oxidative Cleavage of Olefins to Carboxylic Acids with Hydrogen Peroxide Catalyzed by Methyltrioctylammonium Tetrakis(oxodiperoxotungsto)phosphate(3−) under Two-Phase Conditions. Synthetic Aspects and Investigation of the Reaction Course

et al. 1998

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The oxidative cleavage of alkenes to carboxylic acids with 40% w/v aqueous hydrogen peroxide catalyzed by methyltrioctylammonium tetrakis(oxodiperoxotungsto)phosphate(3-) (Ia) is reported to occur in high yields and selectivities under two-phase conditions in the absence of organic solvents. On the basis of a study of the reaction, two main reaction pathways leading to acids have been recognized, the first one involving the perhydrolysis and the second one the hydrolysis of the epoxide initially formed. The "perhydrolytic" reaction pathway appears to play a primary role in the oxidation of medium- and long-chain alkenes to acids, while it intervenes to a rather limited extent in the oxidation of arylalkenes and C(5)-C(7) cycloalkenes. The occurrence of this pathway has been proved by the isolation of the intermediate beta-hydroperoxy alcohols and their transformation into acids with H(2)O(2) and Ia. The course of this transformation, involving an initial oxidation (to alpha-oxo hydroperoxide) or decomposition (to carbonyl compounds) of the beta-hydroperoxy alcohol intermediate, is described. The primary oxidation products, alpha-hydroperoxy ketones, have been isolated in the case of internal beta-hydroperoxy alcohols, whereas their presence has been evidenced with terminal beta-hydroperoxy alcohols bearing a secondary hydroxy group. Hydrogen peroxide concentration appears to exert a remarkable influence on medium acidity, and its effects on the reaction efficiency are shown.

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