Bifunctional tissue‐engineered composite construct for bone regeneration: The role of copper and fibrin
Azam Bozorgi,
Mozafar Khazaei,
Maryam Bozorgi
et al.
Abstract:Bifunctional tissue engineering constructs promoting osteogenesis and angiogenesis are essential for bone regeneration. Metal ion‐incorporated scaffolds and fibrin encapsulation attract much attention due to low cost, nontoxicity, and tunable control over ion and growth factor release. Herein, we investigated the effect of Cu.nHA/Cs/Gel scaffold and fibrin encapsulation on osteogenic and angiogenic differentiation of Wharton's jelly mesenchymal stem cells (WJMSCs) in vitro and in vivo. Cu‐laden scaffolds were … Show more
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