Bifunctional tetrazole–carboxylate ligand based Zn(ii) complexes: synthesis and their excellent potential anticancer properties

Abstract

Two Zn(ii) complexes based on tetrazol were prepared. Nanoparticles of the complexes can inhibit the proliferation of cancer cells in vitro. This work provided a strategy on designing anticancer materials based on coordination complexes.

An efficient one-pot synthesis of pyrazole complexes formed in situ: synthesis, crystal structure, Hirshfeld surface analysis and in vitro biological properties

“…In recent years, a great effort has been devoted to the selfassembly of inorganic molecules in the solid state, because it allows the design of new solids with specific properties, especially playing an important role in bio-inorganic, coordination and medicinal inorganic chemistry. In situ metal-ligand synthesis reactions have attracted continuous attention in recent years, because they, as a bridge between coordination chemistry and organic chemistry, may simplify the synthesis and purification of organic ligands and/or the construction of new coordination complexes (Hayashi, 2016;Ou et al, 2015;Tan et al, 2022;Zhang, 2005).…”

A multi-spectroscopic and molecular docking approach for DNA/protein binding study and cell viability assay of first-time reported pendent azide bearing Cu(II)-quercetin and dicyanamide bearing Zn(II)-quercetin complexes

“…At the same time, the several side effects of cisplatin [ 41 ] boost chemists to develop nonplatinum metal complexes with effective biomedical applications. It is already proved that in anticancer drug development research, Cu and Zn complexes are acceptable non-platinum metal complexes [ [42] , [43] , [44] , [45] , [46] , [47] ] with effective anticancer properties. A thorough search discloses that Cu-quercetin and Zn-quercetin complexes have been already studied with respect to their DNA and HSA binding.…”