Bifunctional fluorescent benzimidazo[1,2-α]quinolines for Candida spp. biofilm detection and biocidal activity

Souza, Igor Oliveira Palagi de; Schrekker, Clarissa M. L.; Lopes, William; Orru, Romano V. A.; Hranjec, Marijana; Perin, Nataša; Machado, Michel Mansur; Oliveira, Luís Flávio Souza de; Donato, Ricardo K.; Stéfani, Valter; Schrekker, Henri Stephan

doi:10.1016/j.jphotobiol.2016.08.037

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…(LIII) against yeast cells and biofilms seemed promising. The compound showed significant activity against C. Albicans CA01 with MIC value of 4 μg/mL [51].…”

Section: -(1h-benzo[d]imidazol-2-yl)-2-(4-fluorophenyl)quinoline Deri...mentioning

confidence: 99%

Current Development in the Synthesis of Benzimidazole-Quinoline Hybrid Analogues and Their Biological Applications

Khalifa,

Upadhyay,

Kumari

et al. 2023

Strategies for the Synthesis of Heterocycles and Their Applications

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Heterocyclic compounds have an essential role in many domains of medicinal chemistry. Many pharmaceutical industries use and investigate nitrogen-containing heterocycles because they are crucial in discovering and developing novel therapeutically active compounds. The benzimidazole moiety is a fundamental component of many heterocyclic scaffolds, which play an important role in producing a wide range of biological activities. Similarly, quinoline is also a versatile bicyclic heterocyclic scaffold with many medicinal applications. It is an essential scaffold for drug discovery leads, and it plays a significant role in medicinal chemistry and has biological activities similar to benzimidazole scaffolds. The present chapter discusses the quinoline-benzimidazole hybrids scaffolds and their potential pharmacological activities.

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“…(LIII) against yeast cells and biofilms seemed promising. The compound showed significant activity against C. Albicans CA01 with MIC value of 4 μg/mL [51].…”

Section: -(1h-benzo[d]imidazol-2-yl)-2-(4-fluorophenyl)quinoline Deri...mentioning

confidence: 99%

Current Development in the Synthesis of Benzimidazole-Quinoline Hybrid Analogues and Their Biological Applications

Khalifa,

Upadhyay,

Kumari

et al. 2023

Strategies for the Synthesis of Heterocycles and Their Applications

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“…2.3 Antibiofilm activity of nanomaterials 2.3 Antimicrobial Models for Nanomaterials Evaluation evaluation of biocidal activity, various methodologies have been used, such as those proposed by the Environmental Protection Agency (EPA), American Society for Testing and Materials (ASTM), and European Standards (EN) for evaluation of bactericidal, fungicidal, parasiticidal, and virucidal activity (Bloomfield et al 2017;Malone et al 2017;Soltani and Pouypouy 2019); these protocols are developed to determine the ability of a chemical or microorganisms to destroy and control harmful organisms for use in medicine, agriculture, and industry (Chattopadhyay et al 2017;Parmar et al 2017;Allah et al 2019). Unfortunately, the methodologies to determine the biocidal activity continue with the problem of their visual reading and their techniques not robust or automated, so they have tried to apply fluorescent methods and flow cytometry in order to reduce these disadvantages but still without an approved protocol for global use (Tidwell et al 2015;de Souza et al 2016;Helmi et al 2018;Vanhauteghem et al 2019). A similar situation was the protocol for the evaluation of biofilms that despite having approved methodologies to evaluate both static biofilms using the MBEC assay (ASTM E2799) and inflow using CDC biofilm reactor (ASTM E2562), the automation of these tests to make them more reproducible and robust is still far from being a reality (Gazzola et al 2015;Kerstens et al 2015;Larimer et al 2016;Bogachev et al 2018).…”

Section: Antimicrobial Models For Nanomaterials Evaluationmentioning

confidence: 99%

Antimicrobial Activity of Nanomaterials: From Selection to Application

Bueno¹

2020

Nanotechnology in the Life Sciences

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The correct application of nanotechnology for the treatment and control of antimicrobial resistance requires the implementation of translational science protocols capable of selecting the most active products with the lowest toxicity and that can be applied in the different areas where they may be needed. In this order of ideas, the selection of a reproducible antimicrobial platform that can be scalable, robust, and automatable becomes a necessity to be solved by nanotechnology researchers. Thus, the design and development of nanomaterials should be together with the implementation of evaluation and toxicity protocols in order to determine the promising nanoproducts to be used in the different innovations. For this reason, the objective of this chapter is to analyze the elements to be considered in the selection, implementation, and standardization of the necessary platforms to translate

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“…A fluorescent benzimidazo[1,2-α] quinoline was identified within a set of nine benzimidazole derivatives as bifunctional Candida spp. biofilm detector and eradicator (de Souza et al 2016). Compound 37 (Fig.…”

Section: Antifungal Activitymentioning

confidence: 99%

Quinolines and Quinolones as Antibacterial, Antifungal, Anti-virulence, Antiviral and Anti-parasitic Agents

Šenerović

Opsenica

Morić

et al. 2019

Advances in Experimental Medicine and Biology

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Infective diseases have become health threat of a global proportion due to appearance and spread of microorganisms resistant to majority of therapeutics currently used for their treatment. Therefore, there is a constant need for development of new antimicrobial agents, as well as novel therapeutic strategies. Quinolines and quinolones, isolated from plants, animals, and microorganisms, have demonstrated numerous biological activities such as antimicrobial, insecticidal, antiinflammatory, antiplatelet, and antitumor. For more than two centuries quinoline/quinolone moiety has been used as a scaffold for drug development and even today it represents an inexhaustible inspiration for design and development of novel semi-synthetic or synthetic agents exhibiting broad spectrum of bioactivities. The structural diversity of synthetized compounds provides high and selective activity attained through different mechanisms of action, as well as low toxicity on human cells. This review describes quinoline and quinolone derivatives with antibacterial, antifungal, anti-virulent, antiviral, and anti-parasitic activities with the focus on the last 10 years literature.

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Bifunctional fluorescent benzimidazo[1,2-α]quinolines for Candida spp. biofilm detection and biocidal activity

Cited by 7 publications

References 25 publications

Current Development in the Synthesis of Benzimidazole-Quinoline Hybrid Analogues and Their Biological Applications

Current Development in the Synthesis of Benzimidazole-Quinoline Hybrid Analogues and Their Biological Applications

Antimicrobial Activity of Nanomaterials: From Selection to Application

Quinolines and Quinolones as Antibacterial, Antifungal, Anti-virulence, Antiviral and Anti-parasitic Agents

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