Biflavonoid quercetin protects against cyclophosphamide–induced organ toxicities via modulation of inflammatory cytokines, brain neurotransmitters, and astrocyte immunoreactivity

Onaolapo, Adejoke Yetunde; Ojo, Foluso Olamide; Onaolapo, Olakunle James

doi:10.1016/j.fct.2023.113879

Cited by 4 publications

(2 citation statements)

References 90 publications

(82 reference statements)

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“…Most relevant to our studies, quercetin has been shown to potentiate the anti-tumor action of Adriamycin-induced cardiotoxicity [37]. This finding is in line with the protective effects of phytochemicals against chemotherapy-induced toxicity, as also observed in other systems [38][39][40][41]. Overall, most of the studies have been conducted in vitro, thus limiting the translational significance of their findings as they do not consider critical variables such as the tumor ecosystem and in vivo bioavailability issues.…”

Section: Discussionsupporting

confidence: 64%

Complementarity between Microbiome and Immunity May Account for the Potentiating Effect of Quercetin on the Antitumor Action of Cyclophosphamide in a Triple-Negative Breast Cancer Model

Manni,

Sun,

Schell

et al. 2023

Pharmaceuticals

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Immunotherapy targeting program cell death protein 1 (PD-1) in addition to chemotherapy has improved the survival of triple-negative breast cancer (TNBC) patients. However, the development of resistance and toxicity remain significant problems. Using the translationally relevant 4T1 mouse model of TNBC, we report here that dietary administration of the phytochemical quercetin enhanced the antitumor action of Cyclophosphamide, a cytotoxic drug with significant immunogenic effects that is part of the combination chemotherapy used in TNBC. We observed that quercetin favorably modified the host fecal microbiome by enriching species such as Akkermansia muciniphilia, which has been shown to improve response to anti-PD-1 therapy. We also show that quercetin and, to a greater extent, Cyclophosphamide increased the systemic frequency of T cells and NK cells. In addition, Cyclophosphamide alone and in combination with quercetin reduced the frequency of Treg, which is consistent with an antitumor immune response. On the other hand, Cyclophosphamide did not significantly alter the host microbiome, suggesting complementarity between microbiome- and immune-mediated mechanisms in potentiating the antitumor action of Cyclophosphamide by quercetin. Overall, these results support the potential for microbiota-centered dietary intervention to overcome resistance to chemoimmunotherapy in TNBC.

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Section: Discussionsupporting

confidence: 64%

Complementarity between Microbiome and Immunity May Account for the Potentiating Effect of Quercetin on the Antitumor Action of Cyclophosphamide in a Triple-Negative Breast Cancer Model

Manni,

Sun,

Schell

et al. 2023

Pharmaceuticals

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“…As a result, quercetin, an antioxidant that increases these hormones, caused higher blood levels of testosterone and luteinizing hormone in rabbits exposed to cadmium (57). In addition, the antioxidant properties of quercetin reduce oxidative stress-induced organ toxicity in mice (58). In the same way, quercetin can protect against osteoarthritis (OA) by stopping NLRP3mediated alveolitis and reducing oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Effects of Quercetin on Codeine-Induced Reproductive Hormone Disorder

Mohammed,

Osama Adnan,

Abdaulteef Salih

2025

Egyptian Journal of Veterinary Sciences

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T HE CURRENT research studies quercetin's potential to attenuate its effects on adult male rats' codeine-induced reproductive disorders. Twenty-four male adult rats were separated into four sets, consisting of six male adult rats in every set, and a 56-day treatment was obtained. General, the first set is control, and the second set (Q1) obtained quercetin using a gavage needle administered at a specific dosage (300 mg/kg/day). In contrast, the third set (Q2) obtained codeine(50mg/kg/day) using a gavage needle, and the fourth group (Q3) obtained quercetin and codeine until 56 days. As a result of exposure to codeine, the rats› blood concentrations of luteinizing hormone (L.H.) and testosterone (T.) decreased. Nevertheless, the administration of quercetin caused an elevation in the levels of (L.H.) plus (T.) hormones in the set (Q3) compared with the set (Q2). In group (Q2), there were changes in the testicle›s structure and tissue, mainly in the Sertoli cells. In addition, there was amyloid accumulation inside the seminiferous tubules; these cells were disarrangements and lacked germ cells. Meanwhile, rats given quercetin (Q1) showed improvement in testicular histopathological abnormalities. The present study›s findings, taking quercetin with codeine (Q3), demonstrated that quercetin consumption can attenuate the harmful influences of exposure to codeine on male reproductive function. In conclusion, this study investigated quercetin›s capability to protect rat testis from the histological damage that codeine causes by oxidative stress.

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Assessment of the in-vitro toxicity and in-vivo therapeutic capabilities of Juglans regia on human prostate cancer and prostatic hyperplasia in rats

Stefanucci,

Marinaccio,

Llorent-Martínez

et al. 2024

Food Bioscience

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Biflavonoid quercetin protects against cyclophosphamide–induced organ toxicities via modulation of inflammatory cytokines, brain neurotransmitters, and astrocyte immunoreactivity

Cited by 4 publications

References 90 publications

Complementarity between Microbiome and Immunity May Account for the Potentiating Effect of Quercetin on the Antitumor Action of Cyclophosphamide in a Triple-Negative Breast Cancer Model

Complementarity between Microbiome and Immunity May Account for the Potentiating Effect of Quercetin on the Antitumor Action of Cyclophosphamide in a Triple-Negative Breast Cancer Model

Effects of Quercetin on Codeine-Induced Reproductive Hormone Disorder

Assessment of the in-vitro toxicity and in-vivo therapeutic capabilities of Juglans regia on human prostate cancer and prostatic hyperplasia in rats

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