Biflavonoid fraction from Garcinia kola seed ameliorates hormonal imbalance and testicular oxidative damage by anti-tuberculosis drugs in Wistar rats

Abstract

Kolaviron protects male reproductive system from oxidative damage by anti-tuberculosis drugs via the antioxidative mechanism.

Potential Antioxidative Effects of Kolaviron on Reproductive Function in Streptozotocin-Induced Diabetic Wistar Rats

“…Data from the current study showed that the body, testes, and epididymal weights were significantly lower in STZ-induced diabetic rats than the nondiabetic control group (Figures 3-6). These findings are in agreement with previous studies that also demonstrated a significant decrease in body, testicular, and epididymal weights in diabetic rats [5,18,27,28,33,45,47]. Moreover, variations in animal body and organ weights have been reported to affect spermatogenesis, sperm quality, and sperm concentration [5,18,27,28,33,45,47].…”

“…In other studies, KV restored antioxidant enzymes in the testes of diabetes-induced rats [5,49]. The protective effect of KV observed in the testes and epididymis of diabetic rats might either be due to the inhibition of glycation by the antioxidant enzymes or scavenging abilities of ROS, thus decreasing the formation of LPO [5,[27][28][29][30].…”

“…Thus, LPO in vivo has been implicated as the underlying mechanisms in numerous disorders and diseases such as cardiovascular diseases, cancer, neurological disorders, and aging. The mechanism of free radical-mediated LPO reactions include [46] abstraction of bisallylic hydrogen from polyunsaturated fatty acids to give carbon-centered radicals which rearranges to more stable cis, trans-pentadienyl radicals [33], addition of oxygen to the pentadienyl radical to give lipid peroxyl radicals [26], release of oxygen from the peroxyl radical to give oxygen and pentadienyl radicals, which rapidly react with oxygen to give a thermochemically more stable trans, trans form preferentially than cis, trans form, and [27] intramolecular addition of the peroxyl radical to the double bond to yield bicyclic prostaglandin-type products.…”

“…Garcinia kola (G. kola), commonly referred to as bitter kola, is one of such plants that has been widely used in ethnomedicine [25]. The therapeutic and medicinal values of Garcinia kola are the subject of many studies, and several researchers have described their functional health benefits [5,[26][27][28][29][30] G. kola is an angiosperm plant that belongs to the family of Guttiferae (Clusiaceae) [5,[28][29][30]. It adapts and grows up in moist lowland forest and subtropical or tropical region.…”

“…Polyphenolic compounds are composed of three benzene rings with hydroxyl (OH) groups which preserve antioxidant activity [31,32] (Figure 2). KV, extract from G. kola nut, has shown great potential for use in therapeutic medicine against many health-threatening chronic diseases of the liver and reproductive system and diabetes [5,[25][26][27][28][29][30]. It is widely used in traditional medicine in southern Nigeria for the treatment of different conditions associated with increased OS [5].…”