Bifidobacterium pseudolongum reduces triglycerides by modulating gut microbiota in mice fed high-fat food

Bo, Tingbei; Wen, Jing; Zhao, Yuanchun; Tian, Shuang-Jie; Zhang, Xueying; Wang, Dehua

doi:10.1016/j.jsbmb.2020.105602

Cited by 64 publications

(37 citation statements)

References 53 publications

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“…This result is consistent with the previous findings that Ama promotes the growth of probiotic bacteria in vitro, including Bifidobacterium [23]. Additionally, supplementation of Bifidobacterium pseudolongum significantly decreases the plasma TG levels in obese mice [24]. The current study found a strong negative correlation between the abundance of Bifidobacteriaceae and liver TG concentration.…”

Section: Discussionsupporting

confidence: 93%

Amaranth Supplementation Improves Hepatic Lipid Dysmetabolism and Modulates Gut Microbiota in Mice Fed a High-Fat Diet

Yang

Fukui

Jia

et al. 2021

Foods

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Diet-induced obesity is often associated with gut microbiota dysbiosis, lipid metabolism disorders, and chronic inflammation. Consumption of the pseudocereal Amaranthus mangostanus has multiple nutritional benefits. We investigated the effects of dietary amaranth on lipid metabolism and gut microbiota in high-fat (HF) diet-fed mice. C57BL/6J mice were provided either a control diet, HF diet, or HF diet containing 10% amaranth powder (Ama) for 8 weeks. Ama supplementation significantly reduced the levels of triglycerides, total cholesterol, and phospholipids in the liver. Moreover, Ama supplementation downregulated the expression of lipogenesis-related genes including Hmgcr, Fdt1, and Sgle in the liver. The gut microbiota analysis showed that Ama supplementation reversed HF diet-induced reduction in bacterial diversity and richness. Additionally, beta diversity analysis of the inter-group variability in community structure showed a clear separation between the HF and Ama groups. Linear discriminant analysis effect size analysis revealed that 11 taxa were enriched in the Ama group, whereas 9 taxa were increased in the HF group. We found that family Porphyromonadaceae and unclassified S24-7 showed a strong positive and negative correlation with the lipid parameters, respectively. Taken together, these results indicated that dietary Ama may attenuate HF diet-induced deterioration of gut microbiota structure and hepatic lipid metabolism.

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Section: Discussionsupporting

confidence: 93%

Amaranth Supplementation Improves Hepatic Lipid Dysmetabolism and Modulates Gut Microbiota in Mice Fed a High-Fat Diet

Yang

Fukui

Jia

et al. 2021

Foods

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“…Adzuki bean is rich in polyphenols, dietary fiber, and protein ( Supplementary Table S1 ), which may contribute to the enrichment of Bifidobacterium . Importantly, Bifidobacterium supplementation has been reported to significantly reduce plasma TG level in obese mice [ 39 ]. In addition, Bifidobacterium can alleviate obesity, regulate glucose homeostasis, and produce short-chain fatty acids (SCFAs) [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Zhao

Hou

et al. 2021

Nutrients

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Adzuki bean consumption has many health benefits, but its effects on obesity and regulating gut microbiota imbalances induced by a high-fat diet (HFD) have not been thoroughly studied. Mice were fed a low-fat diet, a HFD, and a HFD supplemented with 15% adzuki bean (HFD-AB) for 12 weeks. Adzuki bean supplementation significantly reduced obesity, lipid accumulation, and serum lipid and lipopolysaccharide (LPS) levels induced by HFD. It also mitigated liver function damage and hepatic steatosis. In particular, adzuki bean supplementation improved glucose homeostasis by increasing insulin sensitivity. In addition, it significantly reversed HFD-induced gut microbiota imbalances. Adzuki bean significantly reduced the ratio of Firmicutes/Bacteroidetes (F/B); enriched the occurrence of Bifidobacterium, Prevotellaceae, Ruminococcus_1, norank_f_Muribaculaceae, Alloprevotella, Muribaculum, Turicibacter, Lachnospiraceae_NK4A136_group, and Lachnoclostridium; and returned HFD-dependent taxa (Desulfovibrionaceae, Bilophila, Ruminiclostridium_9, Blautia, and Ruminiclostridium) back to normal status. PICRUSt2 analysis showed that the changes in gut microbiota induced by adzuki bean supplementation may be associated with the metabolism of carbohydrates, lipids, sulfur, and cysteine and methionine; and LPS biosynthesis; and valine, leucine, and isoleucine degradation.

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“…Bifidobacterium pseudolongum enhances antitumor immunity ( Mager et al., 2020 ), exerts an anti-influenza effect ( Zhang et al., 2020 ), enhances the efficacy of anti-CTLA4 treatment ( Research, A. A for C. 2020 ), and treated obesity ( Bo et al., 2020 ) in an animal model, which inspired us to explore its mechanism from the perspectives of immunity and metabolism. Desulfovibrio piger was found to be significantly increased in patients with inflammatory bowel disease ( Loubinoux et al., 2002 ), but in recent population surveys it was used to predict preserved residual beta cell function in patients with type-1 diabetes ( de Groot et al., 2021 ), and was found to improve hyperglycemia and reduce insulin resistance ( Doumatey et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

919 Syrup Alleviates Postpartum Depression by Modulating the Structure and Metabolism of Gut Microbes and Affecting the Function of the Hippocampal GABA/Glutamate System

Tian

Xing

Zheng

et al. 2021

Front. Cell. Infect. Microbiol.

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Postpartum depression (PPD) is a mental disorder that affects pregnant women around the world, with serious consequences for mothers, families, and children. Its pathogenesis remains unclear, and medications for treating PPD that can be used during lactation remain to be identified. 919 syrup (919 TJ) is a Chinese herbal medicine that has been shown to be beneficial in the treatment of postpartum depression in both clinical and experimental studies. The mechanism of action of 919 TJ is unclear. 919 syrup is ingested orally, making the potential interaction between the drug and the gut microbiome impossible to ignore. We therefore hypothesized that 919 syrup could improve the symptoms of postpartum depression by affecting the structure and function of the intestinal flora, thereby altering hippocampal metabolism. We compared changes in hippocampal metabolism, fecal metabolism, and intestinal microflora of control BALB/c mice, mice with induced untreated PPD, and mice with induced PPD treated with 919 TJ, and found that 4-aminobutyric acid (GABA) in the hippocampus corresponded with PPD behaviors. Based on changes in GABA levels, multiple key gut bacterial species (Mucispirillum schaedleri, Bifidobacterium pseudolongum, Desulfovibrio piger, Alloprevotella tannerae, Bacteroides sp.2.1.33B and Prevotella sp. CAG:755) were associated with PPD. Metabolic markers that may represent the function of the intestinal microbiota in mice with PPD were identified (Met-Arg, urocanic acid, thioetheramide-PC, L-pipecolic acid, and linoleoyl ethanolamide). The relationship between these factors is not a simple one-to-one correspondence, but more likely a network of staggered functions. We therefore believe that the composition and function of the entire intestinal flora should be emphasized in research studying the gut and PPD, rather than changes in the abundance of individual bacterial species. The introduction of this concept of “GutBalance” may help clarify the relationship between gut bacteria and systemic disease.

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Bifidobacterium pseudolongum reduces triglycerides by modulating gut microbiota in mice fed high-fat food

Cited by 64 publications

References 53 publications

Amaranth Supplementation Improves Hepatic Lipid Dysmetabolism and Modulates Gut Microbiota in Mice Fed a High-Fat Diet

Amaranth Supplementation Improves Hepatic Lipid Dysmetabolism and Modulates Gut Microbiota in Mice Fed a High-Fat Diet

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

919 Syrup Alleviates Postpartum Depression by Modulating the Structure and Metabolism of Gut Microbes and Affecting the Function of the Hippocampal GABA/Glutamate System

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