Bifidobacterium infantisstrains with and without a combination of Oligofructose and Inulin (OFI) attenuate inflammation in DSS-induced colitis in rats

Osman, Nadia; Adawi, Diya; Molin, Göran; Ahrné, Siv; Berggren, Anna; Jeppsson, Bengt

doi:10.1186/1471-230x-6-31

Cited by 121 publications

(91 citation statements)

References 35 publications

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“…This effect was counteracted by normalizing the calcium intake of the rats. 68,69 In contrast, Osman et al 70 showed a reduction of bacterial translocation to the liver in a dextran sulfate sodium (DSS)-induced colitis in rats fed oligofructose, whereas bacterial translocation was increased using a combination of oligofructose, inulin, and B. infantis DSM 15158. Mangell et al 71 showed that Lactobacillus plantarum 299v reduced bacterial translocation to liver and mesenteric lymph nodes in rats, whereas prebiotics (oatmeal) did not prevent this.…”

Section: Adverse Effects Of Prebioticsmentioning

confidence: 96%

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Prebiotics in Chronic Intestinal Inflammation

Langen

Dieleman

2009

Inflammatory Bowel Diseases

156

107

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Prebiotics are nondigestible fermentable fibers that are reported to have health benefits for the host. Older as well as more recent studies show beneficial effects in experimental colitis and lately also in human inflammatory bowel diseases (IBD), such as Crohn's disease, ulcerative colitis, and chronic pouchitis. In this review we give an overview of the benefits of prebiotics in rodent IBD models and in IBD patients and discuss their possible protective mechanisms. Commensal intestinal bacteria induce and perpetuate chronic intestinal inflammation, whereas others are protective. However, most of the current medications are directed against the exaggerated proinflammatory immune response of the host, some of them toxic and costly. Feeding prebiotics changes the composition of the intestinal microflora toward more protective intestinal bacteria and alters systemic and mucosal immune responses of the host. Therapy for IBD targeting intestinal bacteria and their function is just emerging. Prebiotics have the promise to be relatively safe, inexpensive, and easy to administer. Unraveling their protective mechanisms will help to develop rational applications of prebiotics. However, the initial promising results with dietary prebiotics in preclinical trials as well as small studies in human IBD will need to be confirmed in large randomized controlled clinical trials. Keywords ulcerative colitis; Crohn's disease; prebiotics; bifidobacteria; lactobacilli The incidence and prevalence of chronic inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), are increasing in the developed northern hemisphere. Bernstein et al 1 recently published data that showed that Canada has the highest incidence and prevalence of CD thus far reported. The incidence rate for CD ranged from 8.8-20.2 per 100,000 and the prevalence ranged from 161-319 per 100,000. The incidence and prevalence of UC was lower, ranging from 9.9-19.5 and 162-249 per 100,000, respectively. Approximately 0.5% of the Canadian population has IBD. Several studies concerning the pathogenesis of IBD indicate that a combination of factors such as genetic susceptibility, intestinal microflora, dietary factors, intestinal barrier dysfunction, and an abnormal immune response to intestinal bacteria lead to chronic intestinal inflammation. CIHR Author Manuscript CIHR Author Manuscript CIHR Author Manuscript Current IBD TherapeuticsThe current medical armamentarium to treat UC and CD consists of 5-aminosalicylic acid (ASA) compounds, corticosteroids, azathioprine/6-mercaptopurine, methotrexate, and cyclosporine. Recently several biologics have been added to this list. 5 Most patients respond well to these therapies, but for some patients it is still inadequate and/or induces intolerable and serious side effects. In addition, the current therapies are mostly directed against the overly aggressive adaptive immune response of the host, but fail to correct potential environmental triggers such as the intestinal microflora that induces a...

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Section: Adverse Effects Of Prebioticsmentioning

confidence: 96%

“…OFI alone or the B. infantis strains with and without OFI improved the DSS-induced acute colitis. 70 Two studies using oral administration of lactulose in a DSS rat model (300-1000 mg/kg twice daily) and TNBS rat model showed reduction of colonic inflammation after 6 or 14 days, respectively. This effect was dose-dependent.…”

Section: Dss-induced Colitismentioning

confidence: 99%

Prebiotics in Chronic Intestinal Inflammation

Langen

Dieleman

2009

Inflammatory Bowel Diseases

156

107

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“…Moreover the IFN-γ levels were significantly increased in the TNBS model in comparison with other acute and chronic models. Animal models of colitis have been employed to assess the anti-inflammatory effects of plant extracts or their components, polyherbal formulation and probiotics (Jagtap et al 2004;Mahgoub 2003;Osman et al 2006).…”

Section: Inflammation Dth/chs Reaction Carrageenan Paw Oedema Colimentioning

confidence: 99%

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Juhás¹,

Bujňáková²,

Rehák³

et al. 2008

Acta Vet. Brno

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Juhás Š., D. Bujňáková, P. Rehák, Š. Čikoš, S. Czikková, J. Veselá, G. Iľková, J. Koppel: Anti-Inflammatory Effects of Thyme Essential Oil in Mice. Acta Vet. Brno 2008, 77: 327-334. Plant essential oils are plant secondary metabolites possessing various pharmacological properties, primarily anti-oxidative, antimicrobial or immunomodulatory ones. The aim of this work was to study the effects of thyme essential oil dietary administration in murine DTH/ CHS reaction, carrageenan paw oedema and TNBS colitis. Thyme essential oil was added to the murine diet at three concentrations (5000, 2500 and 1250 ppm) and fed to Balb/c mice. The extent of ear swelling in DTH/CHS reaction and paw oedema induced by carrageenan application was measured using the Mitutoyo thickness gauge. In the model of TNBS colitis we evaluated the changes in body weight, the colon weight : body weight ratio, bacterial translocation to mesenteric lymph nodes, and macroscopical and histological scores. IL-1 and IL-6 messenger RNA expression in colonic samples of one experimental group were assessed using quantitative real-time reverse transcriptase PCR. Dietary supplementation with 5000 ppm of thyme essential oil significantly decreased paw oedema and ear swelling. This thyme essential oil concentration caused a significant inhibition of total mRNA IL-1 expression in the mouse colon, and markedly decreased the macroscopic and microscopic scores of colitis. On the other hand, the 1250 ppm of thyme essential oil in diet increased ear oedema induced by oxazolone application in mice. Our study indicates that thyme essential oil is able to affect murine experimental inflammatory models depending on the concentration used. It is concluded that the anti-inflammatory effects of thyme essential oil should be interpreted with a caution due to its contradictory, dose-related effects.

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“…15 A prebiotic mixture containing inulin and oligofructose administered for 2 weeks showed a 10-fold increase in the number of the bifidobacteria and lactobacilli in human intestine, 16 in addition to their immunomodulatory properties in clinical IBD patient trials 13 and in experimental colitis. 17,18 Inulin alone or in combination with Bifidibacterium infantis strains significantly improved the disease activity indexes and decreased both colonic MPO activity and expression of inflammatory mediators. 19 Lactulose, another synthetic prebiotic, also demonstrated a preventative anti-inflammatory effect in TNBS-induced colitis 5 and IBD patients.…”

Section: Discussionmentioning

confidence: 95%

Dietary Polydextrose Prevents Inflammatory Bowel Disease in Trinitrobenzenesulfonic Acid Model of Rat Colitis

Witaicenis

Fruet

Salem

et al. 2010

Journal of Medicinal Food

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Inflammatory bowel disease (IBD) is a multifactorial intestinal disorder that involves interactions among the immune system, genetic susceptibility, and environmental factors, especially the bacterial flora. Polydextrose, a polysaccharide constituted by 90% nondigestible and nonabsorbable soluble fibers, has several physiological effects consistent with those of dietary fibers, including proliferation of colon microflora. Because sulfasalazine presents serious side effects through long-term use at high doses, the aim of the present study was to evaluate the preventative effect of polydextrose on trinitrobenzenesulfonic acid-induced intestinal inflammation and its effects on the intestinal anti-inflammatory activity of sulfasalazine. Results indicated that polydextrose and its association with sulfasalazine present an anti-inflammatory effect that reduces myeloperoxidase activity, counteracts glutathione content, and promotes reductions in lesion extension and colonic weight=length ratio.

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Bifidobacterium infantisstrains with and without a combination of Oligofructose and Inulin (OFI) attenuate inflammation in DSS-induced colitis in rats

Cited by 121 publications

References 35 publications

Prebiotics in Chronic Intestinal Inflammation

Prebiotics in Chronic Intestinal Inflammation

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Dietary Polydextrose Prevents Inflammatory Bowel Disease in Trinitrobenzenesulfonic Acid Model of Rat Colitis

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