Bifidobacterium breve Bif11 supplementation improves depression-related neurobehavioural and neuroinflammatory changes in the mouse

Sushma, Gunuputi; Vaidya, Bhupesh; Sharma, Shikha; Devabattula, Geetanjali; Bishnoi, Mahendra; Kondepudi, Kanthi Kiran; Sharma, Shyam Sunder

doi:10.1016/j.neuropharm.2023.109480

Cited by 7 publications

(3 citation statements)

References 91 publications

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“…39 The use of anti-inflammatory drugs to suppress microglia-mediated inflammation has been shown to alleviate depressive symptoms, and a growing body of evidence suggests that depressive-like phenotypes can arise owing to the imbalance between pro-and anti-inflammatory cytokine production. 38,40 Here, engeletin was found to promote the upregulation of anti-inflammatory IL-10 within the mPFC in CSDS model mice while suppressing the expression of pro-inflammatory IL-1β, IL-6 and TNFα. As peripheral cytokines are generally limited in their ability to cross the blood-brain barrier, microglia serve as a main source of these inflammatory mediators within the CNS, promoting neuroinflammation that is central to the pathogenesis of CSDS-associated depressive-like behaviours.…”

Section: Lcn2 Overexpression Abrogates the Impact Of Engeletin On The...mentioning

confidence: 87%

“…After stimulation by external pathogenic factors, such as LPS and chronic stress, microglia transform into the amoeboid‐state and secrete a large number of inflammatory mediators and cytotoxic molecules, leading to damage in peripheral nerve cells 39 . The use of anti‐inflammatory drugs to suppress microglia‐mediated inflammation has been shown to alleviate depressive symptoms, and a growing body of evidence suggests that depressive‐like phenotypes can arise owing to the imbalance between pro‐ and anti‐inflammatory cytokine production 38,40 . Here, engeletin was found to promote the upregulation of anti‐inflammatory IL‐10 within the mPFC in CSDS model mice while suppressing the expression of pro‐inflammatory IL‐1β, IL‐6 and TNF‐α.…”

Section: Discussionmentioning

confidence: 99%

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Engeletin alleviates depressive‐like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway

Zhang,

Song,

Huo

et al. 2024

J Cellular Molecular Medi

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Microglial polarization and associated inflammatory activity are the key mediators of depression pathogenesis. The natural Smilax glabra rhizomilax derivative engeletin has been reported to exhibit robust anti‐inflammatory activity, but no studies to date have examined the mechanisms through which it can treat depressive symptoms. We showed that treatment for 21 days with engeletin significantly alleviated depressive‐like behaviours in chronic stress social defeat stress (CSDS) model mice. T1‐weighted imaging (T1WI), T2‐weighted imaging (T2WI) imaging revealed no significant differences between groups, but the bilateral prefrontal cortex of CSDS mice exhibited significant increases in apparent diffusion coefficient and T2 values relative to normal control mice, with a corresponding reduction in fractional anisotropy, while engeletin reversed all of these changes. CSDS resulted in higher levels of IL‐1β, IL‐6, and TNF‐a production, enhanced microglial activation, and greater M1 polarization with a concomitant decrease in M2 polarization in the mPFC, whereas engeletin treatment effectively abrogated these CSDS‐related pathological changes. Engeletin was further found to suppress the LCN2/C‐X‐C motif chemokine ligand 10 (CXCL10) signalling axis such that adeno‐associated virus‐induced LCN2 overexpression ablated the antidepressant effects of engeletin and reversed its beneficial effects on the M1/M2 polarization of microglia. In conclusion, engeletin can alleviate CSDS‐induced depressive‐like behaviours by regulating the LCN2/CXCL10 pathway and thereby altering the polarization of microglia. These data suggest that the antidepressant effects of engeletin are correlated with the polarization of microglia, highlighting a potential avenue for future design of antidepressant strategies that specifically target the microglia.

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Section: Lcn2 Overexpression Abrogates the Impact Of Engeletin On The...mentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Engeletin alleviates depressive‐like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway

Zhang,

Song,

Huo

et al. 2024

J Cellular Molecular Medi

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“…In our study, the Mod group norank_f_Muribaculacea , Lactobacillus was elevated, and the abundance of these two genera decreased significantly after the intervention of Ziyan green tea. Bifidobacterium has been associated with beneficial psychobiological effects ( Rothenberg and Zhang, 2019 ), Bifidobacterium breve CCFM1025 was validated to have an antidepressant-like effect in mice, supplementation of Bifidobacterium breve CCFM1025 and Bifidobacterium breve Bif11 to depressed patients and animals can alleviate their depressive behaviors, and their antidepressant mechanisms include attenuating over-responsiveness of the HPA axis and inhibiting the expression of inflammatory factors, enhancing the expression of 5-hydroxytryptophan (5-HT) in the intestines and the brain, and ameliorating the damage of intestinal permeability ( Tian et al, 2020 , 2022 ; Sushma et al, 2023 ). Faecalibaculum was associated with NCPB (negative cognitive processing bias) and depressive symptoms, it was demonstrated that NCPB levels were positively correlated with depressive symptoms and anxiety symptoms ( p < 0.01).…”

Section: Discussionmentioning

confidence: 99%

Investigating the antidepressant effect of Ziyan green tea on chronic unpredictable mild stress mice through fecal metabolomics

Jia,

Tang,

Zou

et al. 2023

Front. Microbiol.

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IntroductionSome studies have shown the effectiveness of tea in reducing depression. Gut flora dysfunction is strongly associated with depression. The mechanism by which Ziyan green tea ameliorates depression is not clear.MethodsIn this study, we examined the impact of Ziyan green tea on mice exhibiting symptoms similar to depression. We specifically focused on the role of intestinal flora and its metabolites. We first established a chronic unpredictable mild stress (CUMS) mouse model to induce depressive symptoms and conducted behavioural tests, biochemical tests, and pathological tissue analysis. We also investigated gut microbiota changes by 16S rRNA sequencing and measured faecal metabolites in mice using UHPLC-MS/MS.ResultsThe results showed that Ziyan green tea intervention improved depression-like behaviour, neurobiochemical factors, and reduced levels of pro-inflammatory factors in CUMS mice. Spearman’s correlation analysis showed that different microbial communities (Corynebacterium, Faecalibaculum, Enterorhabdus, Desulfovibrio) correlation with differential metabolites (Cholic acid, Deoxycholic acid, etc.) and depression-related biochemical indicators (5-HT, DA, BDNF, IL-6, and TNF-α).DiscussionIn conclusion, our findings suggest that both low and high-dose interventions of Ziyan green tea have positive preventive effects on CUMS mice without dose dependence, partly because they mainly affect intestinal Purine Metabolism, Bile Acid Biosynthesis and Cysteine Metabolism in CUMS mice, thus stimulating brain 5-HT, DA and BDNF, and decreasing the inflammatory factors IL-6, TNF-α, activate the composition of intestinal flora, improve the intestinal flora environment and thus promote the production of intestinal metabolites, which can be used for depression treatment. It is suggested that Ziyan green tea may achieve an antidepressant effect through the gut-microbiota-brain axis.

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Effect of Clemizole on Alpha-Synuclein-Preformed Fibrils-Induced Parkinson’s Disease Pathology: A Pharmacological Investigation

Vaidya,

Gupta,

Biswas

et al. 2024

Neuromol Med

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Bifidobacterium breve Bif11 supplementation improves depression-related neurobehavioural and neuroinflammatory changes in the mouse

Cited by 7 publications

References 91 publications

Engeletin alleviates depressive‐like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway

Engeletin alleviates depressive‐like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway

Investigating the antidepressant effect of Ziyan green tea on chronic unpredictable mild stress mice through fecal metabolomics

Effect of Clemizole on Alpha-Synuclein-Preformed Fibrils-Induced Parkinson’s Disease Pathology: A Pharmacological Investigation

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