Bifidobacterium bifidum TMC3115 Can Characteristically Influence Glucose and Lipid Profile and Intestinal Microbiota in the Middle-Aged and Elderly

Wang, Ke; Yu, Xiao-Hong; Li, Yang; Guo, Yun; Lin, Ge; Pu, Fangfang; Ma, Xiaojing; Cui, Wenjing; Marrota, Francesco; He, Fang; Li, Ming

doi:10.1007/s12602-018-9441-8

Cited by 39 publications

(35 citation statements)

References 51 publications

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“…Lactulose supplementation significantly increased the fecal sodium and water in the HSLD‐fed mice (Figure B and Figure S4, Supporting Information) and lowered the serum sodium (Table ), indicating the positive effects of lactulose in alleviating salt‐sensitive hypertension. Bifidobacterium supplementation can relieve constipation and increase defecation frequency . In the present study, Bifidobacterium was significantly increased in the intestinal tracts of the HSLD‐fed mice and thus may be vital to relieving constipation.…”

Section: Discussionsupporting

confidence: 53%

Targeting the Gut Microbiota to Investigate the Mechanism of Lactulose in Negating the Effects of a High‐Salt Diet on Hypertension

Zheng

Zhao

Tian

et al. 2019

Molecular Nutrition Food Res

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Scope: High-salt diets (HSDs) are widely considered to cause health problems such as gut microecological imbalances, constipation, and hypertension. This study explores how lactulose as a safe molecule can stimulate bodily responses to alleviate salt-sensitive hypertension by regulating the gut microbiotas of HSD-fed mice. Methods and results: After 4 weeks, the blood pressures of mice fed a high-salt plus lactulose diet (HSLD) are significantly lower than those of the HSD-fed mice. The HSD increases the abundances of Alistipes and Ruminococcaceae UCG 009 and reduced the abundance of Lactobacillus in the gut, while lactulose supplementation increases the abundances of Bifidobacterium, Alloprevotella, and Subdoligranulum. Fecal metabolic profiling shows significant increases in metabolites involved in ATP-binding cassette transporter pathways, and tryptophan metabolism is significantly reduced in the HSLD group compared with the HSD group. Lactulose maintains the intestinal microenvironmental health in the HSD-fed mice by improving glycolipid metabolism, decreasing the small intestinal interleukin-17a (IL-17a) and interleukin-22 (IL-22) mRNA levels and serum IL-17a and IL-22 levels, relieving constipation, increasing fecal sodium, and reducing intestinal permeability. Conclusion: Lactulose negates salt-sensitive hypertension. Regulating the gut microbiota is a potential treatment for salt-sensitive hypertension.

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Section: Discussionsupporting

confidence: 53%

Targeting the Gut Microbiota to Investigate the Mechanism of Lactulose in Negating the Effects of a High‐Salt Diet on Hypertension

Zheng

Zhao

Tian

et al. 2019

Molecular Nutrition Food Res

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“…Waist circumference was measured midway between the lower rib margin and the iliac crest using a non-expandable measuring tape to the nearest 0.5 cm. body mass index (BMI) was calculated as the weight (kg) divided by squared height (m 2 ) and was interpreted according to the WHO 2000 guideline [ 3 ]. A sphygmomanometer was used to measure blood pressure after participants had rested for 5 min in the sitting position.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, the current challenge is to maintain “active longevity” by extending the healthy lifespan and reducing the duration of illness. The human intestinal microbiota play an important role in maintaining gastrointestinal homeostasis and are beneficial for host health [ 3 ]. Further, dysbiosis led to an imbalance of beneficial and harmful microorganisms [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The human intestinal microbiota play an important role in maintaining gastrointestinal homeostasis and are beneficial for host health [ 3 ]. Further, dysbiosis led to an imbalance of beneficial and harmful microorganisms [ 3 ]. Gut microbiota dysbiosis causes, and is associated with, several diseases, ranging from localized gastrointestinal disorders (including constipation) and metabolic alterations, to respiratory, liver, cardiovascular, and psychiatric neurological disorders [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Gut microbiota dysbiosis causes, and is associated with, several diseases, ranging from localized gastrointestinal disorders (including constipation) and metabolic alterations, to respiratory, liver, cardiovascular, and psychiatric neurological disorders [ 4 ]. Using probiotics has been proposed as a potential therapy to restore the balance of healthy human intestinal function and gut bacterial composition [ 3 ]. According to the official definition of the World Health Organization (WHO), probiotics are “live microorganisms, which when consumed in adequate amounts, confer a healthy effect on the host” [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between Altered Blood Parameters and Gut Microbiota after Synbiotic Intake in Healthy, Elderly Korean Women

et al. 2020

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Synbiotics intake can alter the composition of intestinal microbes beneficially. We aimed to detect the changes in the intestinal microbiomes of 37 healthy elderly Korean women after the intake of a synbiotic drink. This was a longitudinal study controlled with a temporal series, including a control period of 3 weeks before intake, synbiotic intake for 3 weeks, and a washout period of 3 weeks. Fecal microbiota composition was analyzed by sequencing the V3-V4 hypervariable regions of 16S rRNA. Physical fecal activity increased with improvement in fecal shape. Thirty intestinal bacterial taxa were observed to change only after the intake period. In particular, Ellagibacter appeared only after ingestion. In addition, the abundance of Terrisporobacter showed a positive correlation with C-reactive protein, triglyceride. Lachnospiraceae_uc, Eubacterium_g5, and Blautia had a positive correlation with creatinine, whereas PAC001100_g had a negative correlation with creatinine. Short-term (3 weeks) intake of symbiotic organisms changes the composition of the gut microbiota in healthy elderly Korean women.

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Screening Potential Probiotics Against Obesity and Metabolism Abnormalities in the Elderly

Shi²,

Cheng³

et al. 2023

Healthy Ageing and Longevity

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Bifidobacterium bifidum TMC3115 Can Characteristically Influence Glucose and Lipid Profile and Intestinal Microbiota in the Middle-Aged and Elderly

Abstract: ChiCTR-OOC-16010271.

Cited by 39 publications

References 51 publications

Targeting the Gut Microbiota to Investigate the Mechanism of Lactulose in Negating the Effects of a High‐Salt Diet on Hypertension

Targeting the Gut Microbiota to Investigate the Mechanism of Lactulose in Negating the Effects of a High‐Salt Diet on Hypertension

Association between Altered Blood Parameters and Gut Microbiota after Synbiotic Intake in Healthy, Elderly Korean Women

Screening Potential Probiotics Against Obesity and Metabolism Abnormalities in the Elderly

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