Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species

Chen, Shujie; Chen, Luyi; Qi, Yadong; Xu, Jiawen; Ge, Qiwei; Fan, Yuedan; Du, Chen; Zhang, Yawen; Wang, Lan; Hou, Tongyao; Yang, Xiaohang; Xi, Yongmei; Si, Jianmin; Kang, Lijun; Wang, Liangjing

doi:10.1038/s43587-021-00129-0

Cited by 23 publications

(19 citation statements)

References 69 publications

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“…Nematode Caenorhabditis elegans (C. elegans) is a extensively used as a powerful model organism for physiological, cell division, molecular biology and many other researches (25), and provide a perfect model to study the interaction between intestine and other organic systems (26,27). In order to test whether VK2 is a potent microbiota product to influence the health of host, we used C. elegans to test the biological effects of VK2 on aging and fat metabolism in this study.…”

Section: Introductionmentioning

confidence: 99%

Vitamin K2 Enhances Fat Degradation to Improve the Survival of C. elegans

Zhang

Huang

et al. 2022

Front. Nutr.

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The beneficial effects of vitamin K (VK) on various chronic age-related syndromes have generally been considered dependent on its antioxidant effects. However, due to the distinct bioavailability and biological activities of VKs, exactly which of these activities and by what mechanisms they might act still need to be elucidated. In this study, we found that VK2 can extend the lifespan of C. elegans and improve the resistance to pathogen infection, heat stress and H2O2-induced inner oxidative stress. Importantly, the roles of VK2 on aging and stress resistance were shown to be dependent on enhanced fat metabolism and not due to its antioxidant effects. Moreover, the genes related to fat metabolism that were up-regulated following VK2 treatment play key roles in improving survival. Obesity is a leading risk factor for developing T2DM, and taking VKs has been previously considered to improve the insulin sensitivity associated with obesity and T2DM risk. However, our results showed that VK2 can significantly influence the expression of genes related to fat metabolism, including those that regulate fatty acid elongation, desaturation, and synthesis of fatty acid-CoA. VK2 enhanced the fatty acid β-oxidation activity in peroxisome to degrade and digest fatty acid-CoA. Our study implies that VK2 can enhance fat degradation and digestion to improve survival, supporting the effectiveness of VK2-based medical treatments. VK2 is mainly produced by gut bacteria, suggesting that VK2 might facilitate communication between the gut microbiota and the host intestinal cells to influence fat metabolism.

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Section: Introductionmentioning

confidence: 99%

Vitamin K2 Enhances Fat Degradation to Improve the Survival of C. elegans

Zhang

Huang

et al. 2022

Front. Nutr.

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“…Our study found that Bifidobacterium pseudocatenulatum, Bifidobacterium longum, and Bifidobacterium adolescentis were decreased in participants of sarcopenia. Bifidobacterium, as probiotics, has been illustrated might be effective for aging due to its ability to modulate oxidative stress and inflammation (Chen et al, 2021;Fang et al, 2021). In addition, Shujie C. et al reported that supplementation with Bifidobacterium adolescentis resulted in an enhancement in skeletal muscle catalase enzyme activity and suppressed cellular senescence in mouse embryonic fibroblasts, and aroused alterations in oxidative stressassociated metabolites (Chen S. et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Metabolites of the gut microbiota may serve as precise diagnostic markers for sarcopenia in the elderly

He,

Cui,

Fang

et al. 2023

Front. Microbiol.

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Sarcopenia, a disease recognized by the World Health Organization, has posed a great challenge to the world in the current aging society. The vital role of the gut microbiome through the gut-muscle axis in sarcopenia is increasingly recognized. However, the working mechanisms by which the gut microbiota functions have not been fully explored in the multi-omics field. Here, we designed a cross-sectional study that recruited patients (n = 32) with sarcopenia and healthy old adults (n = 31). Diagnosis of sarcopenia was based on the Asian Working Group for Sarcopenia (AWGS) in 2019 criteria. Muscle mass was represented by appendicular skeletal muscle mass measured by using direct segmental multi-frequency bioelectrical impedance and muscle strength was evaluated using the handgrip strength. The Short Physical Performance Battery, the 5-time Chair Stand Test, and the 4-metre Walk Test were used to assess physical performance. Shotgun metagenomic sequencing was used to profile the gut microbiome in order to identify its construction and function. Metabolome based on untargeted metabolomics was applied to describe the features and structure of fecal metabolites. In clinical indexes including triglycerides and high-density lipoprotein cholesterol, we noted a significant decrease in triglycerides (TG) and a significant increase in high-density lipoprotein cholesterol (HDL-C) in patients with sarcopenia. Appendicular skeletal muscle mass of patients with sarcopenia was lower than the health group. Based on intestinal metagenomic and fecal metabolomic profiles, we found that the gut microbiome and metabolome were disturbed in patients with sarcopenia, with significant decreases in bacteria such as Bifidobacterium longum, Bifidobacterium pseudocatenulatum, and Bifidobacterium adolescentis, as well as metabolites such as shikimic acid. Also, we plotted supervised classification models at the species level of gut bacteria (AUC = 70.83–88.33) and metabolites (AUC = 92.23–98.33) based on machine learning, respectively. Based on the gut-muscle axis network, a potential mechanism is proposed along the gut microbiome - key metabolites - clinical index, that Phascolarctobacterium faecium affects appendicular skeletal muscle mass, calf circumference, handgrip strength, and BMI via Shikimic acid metabolites. This study elucidates the potential mechanisms by which the gut microbiome influences the progress of sarcopenia through metabolites and provides a meaningful theoretical foundation for reference in the diagnosis and treatment of sarcopenia.

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“…Therefore, the depletion of SCFAproducing species may play a role in the frailty and agerelated diseases. Recent studies have demonstrated that supplementation of Bifidobacterium adolescentis can ameliorate osteoporosis and neurodegeneration of premature aging mice, and further improve healthspan and lifespan in Drosophila and C. elegans (Chen et al, 2021b). On the other hand, the mucin-consuming bacteria Akkermansia is confirmed on its role in maintaining the barrier function and metabolic homeostasis (DeJong et al, 2020;Shin et al, 2019).…”

Section: Aging Microbiomementioning

confidence: 99%

The landscape of aging

Cai

Song

et al. 2022

Sci. China Life Sci.

158

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Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels.

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Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species

Cited by 23 publications

References 69 publications

Vitamin K2 Enhances Fat Degradation to Improve the Survival of C. elegans

Vitamin K2 Enhances Fat Degradation to Improve the Survival of C. elegans

Metabolites of the gut microbiota may serve as precise diagnostic markers for sarcopenia in the elderly

The landscape of aging

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