Bidirectional role of acupuncture in the treatment of drug addiction

Lee, Mi Young; Lee, Bong Hyo; Kim, Hee Young; Yang, Chae Ha

doi:10.1016/j.neubiorev.2021.04.004

Cited by 30 publications

(20 citation statements)

References 159 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The putamen and the primary motor cortex were activated when patients with PD received acupuncture treatment and these activations correlated with individual enhanced motor function [62]. Moreover, it was found that acupuncture can reduce drug addiction via direct activation of brain pathways [63]. In this work, we confirmed that acupuncture can affect the characteristics of the latent neural subspace.…”

Section: Discussionsupporting

confidence: 69%

Low-Dimensional Dynamics of Brain Activity Associated with Manual Acupuncture in Healthy Subjects

Guo

Wang

2021

Sensors

View full text Add to dashboard Cite

Acupuncture is one of the oldest traditional medical treatments in Asian countries. However, the scientific explanation regarding the therapeutic effect of acupuncture is still unknown. The much-discussed hypothesis it that acupuncture’s effects are mediated via autonomic neural networks; nevertheless, dynamic brain activity involved in the acupuncture response has still not been elicited. In this work, we hypothesized that there exists a lower-dimensional subspace of dynamic brain activity across subjects, underpinning the brain’s response to manual acupuncture stimulation. To this end, we employed a variational auto-encoder to probe the latent variables from multichannel EEG signals associated with acupuncture stimulation at the ST36 acupoint. The experimental results demonstrate that manual acupuncture stimuli can reduce the dimensionality of brain activity, which results from the enhancement of oscillatory activity in the delta and alpha frequency bands induced by acupuncture. Moreover, it was found that large-scale brain activity could be constrained within a low-dimensional neural subspace, which is spanned by the “acupuncture mode”. In each neural subspace, the steady dynamics of the brain in response to acupuncture stimuli converge to topologically similar elliptic-shaped attractors across different subjects. The attractor morphology is closely related to the frequency of the acupuncture stimulation. These results shed light on probing the large-scale brain response to manual acupuncture stimuli.

show abstract

Section: Discussionsupporting

confidence: 69%

Low-Dimensional Dynamics of Brain Activity Associated with Manual Acupuncture in Healthy Subjects

Guo

Wang

2021

Sensors

View full text Add to dashboard Cite

show abstract

“…Eine Aktivierung limbischer Hirnareale wie der Amygdala ist mit verstärkter Emotionalität und Stressantwort assoziiert, sodass eine Beruhigung dieser Strukturen einen Teil der Effekte von Akupunktur auf psychiatrische Erkrankungen erklären könnte [110]. Als möglicher Wirkmechanismus der Akupunktur bei Abhängigkeit wird u. a. eine neurobiologische Wirkung auf das Belohnungszentrum diskutiert [111]. Bei neurokognitiven Störungen, wie z.…”

Section: Wirkweise Von Akupunktur Im Psychiatrischen Kontextunclassified

Akupunktur in der Psychiatrie – Chancen und Grenzen

Musil¹,

Hofer²,

Colling³

2021

Zeitschrift für Komplementärmedizin

View full text Add to dashboard Cite

SummaryAkupunktur wird in zunehmendem Umfang an deutschen psychiatrischen Kliniken angeboten. Die Evidenz in der publizierten Literatur hat über die letzten Jahre deutlich zugenommen. Die Qualität der Studien muss sich allerdings weiterhin verbessern, um zu klaren Ergebnissen und Empfehlungen in Metaanalysen zu kommen. Insbesondere bei depressiven Erkrankungen und Traumafolgestörungen könnte Akupunktur durch seine Nebenwirkungsarmut in Zukunft einen größeren Stellenwert gewinnen. Akupunktur lässt sich in unterschiedliche Behandlungsstrategien relativ einfach integrieren. Eine große Hürde stellt allerdings die geringe Verbreitung einer ausreichenden Ausbildung bei Behandlern in psychiatrischen und psychosomatischen Kliniken dar.

show abstract

“…Substance addiction and misuse have evolved into a socio-therapeutic concern [ 2 ]. Trends in usage include the decrease in the mean age of consumers [ 3 ]. The frequency of occupational lead (Pb) poisoning in adults has declined in recent years due to increased workplace safety and improving housing characteristics [ 4 ], although Pb-contaminated drugs could be an emerging source.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study on the Association of Lead, 8-Hydroxyguanine, and Malondialdehyde Levels in Opium Addicts’ Blood Serum with Illicit Drug Use and Non-Addict Persons

Hesaruiyeh

Rajabi

Motamed-Jahromi

et al. 2022

IJERPH

View full text Add to dashboard Cite

While a large body of literature has shown the health problems of illicit drug use, research is needed on how substance abuse impacts DNA damage and contaminants in blood, especially given Pb-contaminated opium. This pilot study aimed to evaluate the levels of lead (Pb), 8-hydroxy di-guanine (8-oxo-Gua), and malondialdehyde (MDA) in the blood serum of opium addicts and non-addict people. The current study is a case–control study with a cross-sectional design. A sample of 50 opium-addicted and non-addict adults were chosen for this study using convenience and random sampling methods. Participants were divided into two groups: addicts and non-addicts. The atomic absorption spectroscopy method was used to measure the quantity of Pb, and the Enzyme-Linked Immunosorbent Assay (ELISA) method was used to measure the amount of 8-oxo-Gua and MDA. The data were analyzed using an independent t-test. The results show that the amount of Pb in the blood serum of addicted women and men was higher than levels in non-addict men and women, for the study participants (p-value = 0.001). Blood levels were not significantly different between addicts and non-addicts for men or women for 8-oxo-Gua (p-value = 0.647 for women and p-value = 0.785 for men) and MDA (p-value = 0.867 for women and p-value = 0.995 for men). In general, addicts’ blood Pb levels were found to be substantially higher than those of normal non-addict persons in this pilot study. As a result, testing for blood Pb levels in addicts may be informative in instances when symptoms are inconclusive.

show abstract

Bidirectional role of acupuncture in the treatment of drug addiction

Cited by 30 publications

References 159 publications

Low-Dimensional Dynamics of Brain Activity Associated with Manual Acupuncture in Healthy Subjects

Low-Dimensional Dynamics of Brain Activity Associated with Manual Acupuncture in Healthy Subjects

Akupunktur in der Psychiatrie – Chancen und Grenzen

A Pilot Study on the Association of Lead, 8-Hydroxyguanine, and Malondialdehyde Levels in Opium Addicts’ Blood Serum with Illicit Drug Use and Non-Addict Persons

Contact Info

Product

Resources

About