“…Multiple centralized neuromodulatory systems widely innervate sensory and integrative brain regions, and respond to changes in environmental conditions [ 64 ]. For example, noradrenergic neurons within the locus coeruleus are sensitive to behaviorally important information, such as social context or stress, are affected by social experience, influence connectivity in neural networks related to salience and affect, and alter performance on sensory and cognitive tasks [ 201 , 202 , 203 , 204 , 205 , 206 ]. These kinds of similarities in some of the aspects of how serotonergic, noradrenergic, and other neurochemical systems work have led to the view that these systems may cooperate in regulating integrative neural functions [ 74 , 207 ].…”