Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma

Yue, Kaile; Sheng, Dashuang; Xue, Xinxin; Zhao, Lanlan; Zhao, Guoping; Jin, Chuandi; Zhang, Lei

doi:10.1128/spectrum.00904-23

Cited by 10 publications

(8 citation statements)

References 63 publications

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“…As for the mechanism, many studies have revealed that non- H. pylori microorganisms promote GC by inducing inflammation, modulating the immune response, triggering DNA damage, and promoting epithelial–mesenchymal transformation ( Yang et al, 2022 ; Liao et al, 2023 ). Gastric non- H. pylori microorganisms may participate in the progression of GC by affecting host DNA methylation ( Yue et al, 2023 ). Different bacterial taxa are related to certain types of infiltrating immune cells ( Liao et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

Ke,

Tan,

Zhen

et al. 2024

Front. Microbiol.

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BackgroundNumerous studies have cast light on the relationship between the gastric microbiota and gastric carcinogenesis. In this study, we conducted a bibliometric analysis of the relevant literature in the field of gastric cancer and the gastric microbiota and clarified its research status, hotspots, and development trends.Materials and methodsPublications were retrieved from the Web of Science Core Collection on 18 July 2023. CiteSpace 6.2.R4, VOSviewer 1.6.19.0, and Biblioshiny were used for the co-occurrence and cooperation analyses of countries, institutions, authors, references, and keywords. A keyword cluster analysis and an emergence analysis were performed, and relevant knowledge maps were drawn.ResultsThe number of published papers in this field totaled 215 and showed an increasing trend. The analysis of funding suggested that the input in this field is increasing steadily. China had the highest number of publications, while the United States had the highest betweenness centrality. Baylor College of Medicine published the most articles cumulatively. Both Ferreira RM and Cooker OO had the highest citation frequency. The journal Helicobacter showed the most interest in this field, while Gut provided a substantial research foundation. A total of 280 keywords were obtained using CiteSpace, which were primarily focused on the eradication and pathogenic mechanisms of Helicobacter pylori, as well as the application of the gastric microbiota in the evaluation and treatment of gastric cancer. The burst analysis suggested that in the future, research may focus on the application of gastric microorganisms, particularly Fusobacterium nucleatum, in the diagnosis and treatment of gastric cancer, along with their pathogenic mechanisms.ConclusionCurrent studies have been tracking the eradication of Helicobacter pylori and its pathogenic mechanisms, as well as changes in the gastric microbiota during gastric carcinogenesis. Future research may focus on the clinical application and pathogenesis of stomach microorganisms through bacteria such as Fusobacterium nucleatum.

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Section: Discussionmentioning

confidence: 99%

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

Ke,

Tan,

Zhen

et al. 2024

Front. Microbiol.

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“…Helicobacter pylori is an ITM known to promote gastric cancer and affects tumors mainly through methylation. By screening methylation pathways H. pylori was observed to be highly enriched in gastric cancer, and cellular experiments have shown that Staphylococcus saccharolyticus promotes gastric cell proliferation and cloning by regulating the gene expression level of the zinc finger protein 215 gene 42 . Thus, screening for methylation pathways may be a potential metabolic target to identify gastric cancer.…”

Section: Itm Identification For Tumor Diagnosis and Stagingmentioning

confidence: 99%

“…In hepatocellular carcinoma, microbial α and β diversities are increased, with a significant increase in the abundance of microorganisms, such as Enterobacteriaceae, Clostridium , and Neisseria , and a decrease in the abundance of certain antitumor bacteria, such as Pseudomonas . In terms of metabolism, processes such as fatty acid and lipid synthesis are significantly enhanced in the microbiota of cancerous tissues 42 . Huang et al 42 have used the ITM model of liver cancer to differentiate between patients with liver cancer and healthy populations, which shows excellent performance with an area under the curve (AUC) of 0.968.…”

Section: Itm Identification For Tumor Diagnosis and Stagingmentioning

confidence: 99%

“…In terms of metabolism, processes such as fatty acid and lipid synthesis are significantly enhanced in the microbiota of cancerous tissues 42 . Huang et al 42 have used the ITM model of liver cancer to differentiate between patients with liver cancer and healthy populations, which shows excellent performance with an area under the curve (AUC) of 0.968. The authors selected the top five groups, including Bacillus , Acidobacter, Parcubacteria, Saccharimonadia, and Gammaproteobacteria, with an AUC of 0.939 in the validation cohort, demonstrating the efficacy of ITM in predicting liver cancer.…”

Section: Itm Identification For Tumor Diagnosis and Stagingmentioning

confidence: 99%

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The value of intratumoral microbiota in the diagnosis and prognosis of tumors

Zhou,

Zhang,

Fan

et al. 2024

Cell Biochemistry & Function

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Intratumoral microbiota (ITM) are microorganisms present in tumor cells. ITM participate in tumor development by affecting tumor cells directly and the tumor microenvironment (TME), indirectly. Alterations in ITM instigate changes in tumor DNA, activate oncogenic pathways, induce tumor inflammatory responses, disrupt normal immune activity, and facilitate the secretion of effectors leading to tumor progression, metastasis, or diminished therapeutic effects. ITM varies significantly in different types of cancer cells and disease states. The presence of certain ITM serves as a predictor of various disease states. Thus, ITM predicts tumorigenesis, tumor grade, treatment efficacy, and prognosis, making it a potential tumor biomarker. The present study aimed to determine the mechanisms by which ITM affects tumor development, especially through the TME; highlight the significant potential of ITM in enhancing tumor diagnosis and prognosis; and outline future directions for ITM research, with a focus on the development of innovative tumor markers.

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“…Moreover, there is also much evidence showing that microbiome regulates the biology of cancer cells via epigenetic mechanisms. In stomach cancer, the intratumor microbiome, especially Kytococcus sedentarius and Actinomyces orisinteracted , was strongly associated with methylation changes in immune‐related genes of cancer cells and regulated gene expression 88 . In esophageal cancer, the presence of F. nucleatum was associated with LINE‐1 hypomethylation, which was associated with poor prognosis 89 .…”

Section: Mechanisms Of Intratumor Microbiome In Modulating Tumor Init...mentioning

confidence: 99%

Intratumor microbiome: selective colonization in the tumor microenvironment and a vital regulator of tumor biology

Jiang,

Yang,

Dai

et al. 2023

MedComm

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The polymorphic microbiome has been proposed as a new hallmark of cancer. Intratumor microbiome has been revealed to play vital roles in regulating tumor initiation and progression, but the regulatory mechanisms have not been fully uncovered. In this review, we illustrated that similar to other components in the tumor microenvironment, the reside and composition of intratumor microbiome are regulated by tumor cells and the surrounding microenvironment. The intratumor hypoxic, immune suppressive, and highly permeable microenvironment may select certain microbiomes, and tumor cells may directly interact with microbiome via molecular binding or secretions. Conversely, the intratumor microbiomes plays vital roles in regulating tumor initiation and progression via regulating the mutational landscape, the function of genes in tumor cells and modulating the tumor microenvironment, including immunity, inflammation, angiogenesis, stem cell niche, etc. Moreover, intratumor microbiome is regulated by anti‐cancer therapies and actively influences therapy response, which could be a therapeutic target or engineered to be a therapy weapon in the clinic. This review highlights the intratumor microbiome as a vital component in the tumor microenvironment, uncovers potential mutual regulatory mechanisms between the tumor microenvironment and intratumor microbiome, and points out the ongoing research directions and drawbacks of the research area, which should broaden our view of microbiome and enlighten further investigation directions.

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Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma

Cited by 10 publications

References 63 publications

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

The value of intratumoral microbiota in the diagnosis and prognosis of tumors

Intratumor microbiome: selective colonization in the tumor microenvironment and a vital regulator of tumor biology

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