Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila

Doherty, Caroline A.; Amargant, Farners; Duncan, Francesca E.; Gavis, Elizabeth R.

doi:10.1016/j.tcb.2021.11.005

Cited by 28 publications

(22 citation statements)

References 101 publications

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“…Ovarian folliculogenesis is a complicated process, filled with the communication between oocytes and granulosa cells, and supported by ovarian stroma ( 40 ). Growing follicles with activated cell proliferation of granulosa are more sensitivity to the toxicity of AAs.…”

Section: Discussionmentioning

confidence: 99%

PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice

Dai

Wang

et al. 2022

Front. Endocrinol.

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Alkylating agents (AAs) that are commonly used for cancer therapy cause great damage to the ovary. Pyrroloquinoline-quinine (PQQ), which was initially identified as a redox cofactor for bacterial dehydrogenases, has been demonstrated to benefit the fertility of females. The aim of this study was to investigate whether PQQ dietary supplementation plays a protective role against alkylating agent-induced ovarian dysfunction. A single dose of busulphan (20 mg/kg) and cyclophosphamide (CTX, 120 mg/kg) were used to establish a mouse model of ovarian dysfunction. Feed containing PQQNa2 (5 mg/kg) was provided starting 1 week before the establishment of the mouse model until the date of sacrifice. One month later, estrous cycle period of mice were examined and recorded for consecutive 30 days. Three months later, some mice were mated with fertile male mice for fertility test. The remaining mice were sacrificed to collect serum samples and ovaries. One day before sacrifice, some mice received a single injection of BrdU to label proliferating cells. Serum samples were used for test hormonal levels. Ovaries were weighted and used to detect follicle counts, cell proliferation, cell apoptosis and cell senescence. In addition, the levels of inflammation, oxidative damage and Pgc1α expression were detected in ovaries. Results showed that PQQ treatment increased the ovarian weight and size, partially normalized the disrupted estrous cycle period and prevented the loss of follicles of mice treated with AAs. More importantly, we found that PQQ treatment significantly increased the pregnancy rate and litter size per delivery of mice treated with AAs. The protective effects of PQQ appeared to be directly mediated by promoting cell proliferation of granulosa, and inhibiting cell apoptosis of granulosa and cell senescence of ovarian stromal cells. The underlying mechanisms may attribute to the anti-oxidative stress, anti-inflammation and pro-mitochondria biogenesis effects of PQQ.Our study highlights the therapeutic potential of PQQ against ovarian dysfunction caused by alkylating agents.

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Section: Discussionmentioning

confidence: 99%

PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice

Dai

Wang

et al. 2022

Front. Endocrinol.

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“…A complex bidirectional attachment between the enclosing cumulus cells and germ cell occurs during oocyte growth and differentiation (Eppig, 1991;Eppig, 2001;Doherty et al, 2022). Oocyte within primordial follicle stage is stopped at prophase of 1 st meiotic stages and enclosed by a single layer-squamous cells.…”

Section: Growing and Fully-grown Germinal Vesicle Oocytesmentioning

confidence: 99%

Changes in Nucleus and Cytoplast During Oocyte Maturation: Involvement in Embryo Production

Zeidi¹,

Masruri²,

Mufarji³

et al. 2022

AAVS

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Embryo production steps either in vivo or in vitro include oocyte meiotic maturation, fertilization and culture processes. Oocyte maturation is the first step for in vivo or in vitro embryo production. Oocyte maturation appears to be a simple step, but it is a very complex process. Maturation of oocytes include several changes at the cytoplasmic and nuclear levels that makes the oocytes able to undergo fertilization, pre-implantation and post-implantation embryo development. Oocyte meiotic maturation in vivo starts after LH hormone surge whereas it starts in vitro upon release of oocyte from the ovarian follicle. Rodent oocyte maturation lasts 15-17hr. whereas that of ruminant oocyte lasts 24hr. Several factors affect on oocytes maturation either in vitro or in vivo and therefore affect development of the resulting embryos. Because of the significance of oocyte maturation stage on further embryonic development, this review aims to discuss the knowledge of oocyte maturation and its effect on further development of embryos in vivo and in vitro.

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“…The remaining ∼90% of FCs differentiate into main body FCs (MBFCs) and posterior FCs (PFCs), which specialize to facilitate oocyte maturation and thus must eventually cover the entire oocyte. However, at the time point of fate specification, germline cells and FCs do not match yet: MBFCs are initially in contact with nurse cells and AFCs cover only a small proportion of the nurse cell compartment 4, 10, 12, 21, 22 . Thus, FCs must redistribute over the germline surface to establish the right match.…”

Section: Introductionmentioning

confidence: 99%

“…Oogenesis is a prime example of a developmental process that depends on the close interaction of two lineages. From invertebrates to vertebrates, oocytes develop within a germline cyst that is enveloped by somatic cells 4 . The germline cyst consists of the oocyte itself and so-called nurse cells [5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

“…The maturation of the oocyte, as well as the removal of nurse cells is strictly dependent on the cooperation with somatic cells enveloping the germline cyst. These socalled follicle cells (FCs) differentiate into diverse cell fates, which, among others, specialize to facilitate oocyte maturation by eggshell secretion or nurse cell removal by phagoptosis 4,7,[9][10][11][12] . Thus, it is essential that germline cells and somatic cells match each other, such that nurse cells are in contact with FCs that facilitate nurse cell removal, and the oocyte is in contact with FCs that enable oocyte maturation.…”

Section: Introductionmentioning

confidence: 99%

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Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis

Classen

Weichselberger

Dondl

2022

Preprint

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Cooperative morphogenesis of cell lineages underlies the development of functional units and organs. To study mechanisms driving the coordination of lineages, we investigated soma-germline interactions during oogenesis. From invertebrates to vertebrates, oocytes develop as part of a germline cyst that consists of the oocyte itself and so-called nurse cells, which feed the oocyte and are eventually removed. The enveloping somatic cells specialize to facilitate either oocyte maturation or nurse cell removal, which makes it essential to establish the right match between germline and somatic cells. We uncover that the transcriptional regulator Eya, expressed in the somatic lineage, controls bilateral cell-cell affinity between germline and somatic cells in Drosophila oogenesis. Employing functional studies and mathematical modelling, we show that differential affinity and the resulting forces drive somatic cell redistribution over the germline surface and control oocyte growth to match oocyte and nurse cells with their respective somatic cells. Thus, our data demonstrate that differential affinity between cell lineages is sufficient to drive the complex assembly of inter-lineage functional units and underlies tissue self-organization during Drosophila oogenesis.

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Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila

Cited by 28 publications

References 101 publications

PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice

PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice

Changes in Nucleus and Cytoplast During Oocyte Maturation: Involvement in Embryo Production

Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis

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