Bidirectional Associations between Handgrip Strength and Depressive Symptoms: A Longitudinal Cohort Study

Lian, Ying; Wang, Gang-Pu; Chen, Guoqiang; Jia, Cun-Xian

doi:10.1016/j.jamda.2021.04.006

Cited by 17 publications

(11 citation statements)

References 45 publications

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“…30,31 Bidirectional analyses suggested that these associations are more likely to be unidirectional, rather than bidirectional, as documented in some observational studies. [32][33][34] According to the frailty phenotype, depression seems to increase physical frailty symptoms, but not the individual component of the frailty phenotype. This could be due to depression being more closely related to impairments of whole-body physical fitness and function, as opposed to limited functional activity captured by a single measure.…”

Section: Discussionmentioning

confidence: 99%

“…For example, a recent cohort study in 13 208 Chinese participants identified an L-shaped dose-response association between depressive symptoms and subsequent decreased grip strength. 32 Several mechanisms have been proposed to support the bidirectional association between frailty and depression. Chronic inflammation, oxidative stress and mitochondrial dysfunction may act as the overlapping biological pathways in both directions.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study

Zhu,

Zhou,

Nie

et al. 2023

J cachexia sarcopenia muscle

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BackgroundObservational studies have demonstrated a strong bidirectional association between frailty and depression, but it remains unclear whether this association reflects causality. This study aimed to examine the bidirectional causal relationship between frailty and depression.MethodsUsing genome‐wide association study summary data, two‐sample Mendelian randomization was performed to test for the potential bidirectional causality between frailty, as defined by both the frailty index and the frailty phenotype, and depression. Several frailty‐related traits were additionally investigated, including weaker hand grip strength, slower walking pace and physical inactivity. Findings were replicated using an independent depression data source and verified using multiple sensitivity analyses.ResultsGenetically predicted higher frailty index (odds ratio [OR], 1.86; P < 0.001), higher frailty phenotype score (OR, 2.79; P < 0.001), lower grip strength (OR, 1.23; P = 0.003), slower walking pace (OR, 1.55; P = 0.027) and physical inactivity (OR, 1.44; P = 0.003) all were associated with a higher risk of depression. As for the reverse direction, genetic liability to depression showed consistent associations with a higher frailty index (beta, 0.167; P < 0.001) and a higher frailty phenotype score (beta, 0.067; P = 0.001), but not with other frailty‐related traits that were investigated. The results were stable across sensitivity analyses and across depression datasets.ConclusionsOur findings add novel evidence supporting the bidirectional causal association between frailty and depression. Improving balance and muscle strength and increasing physical activity may be beneficial in both depression and frailty.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study

Zhu,

Zhou,

Nie

et al. 2023

J cachexia sarcopenia muscle

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“…Existing epidemiological studies have explored the association between depressive symptoms and sarcopenia, with some reporting an increased risk associated with depressive symptoms ( 8 ). Regarding the potential mechanisms, depressive symptoms and sarcopenia share common pathophysiological pathways related to neurotrophins, inflammation, and oxidative stress, in which inflammation is one of the most frequently cited mechanisms ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Relationships Between Depressive Symptoms, Dietary Inflammatory Potential, and Sarcopenia: Mediation Analyses

2022

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BackgroundSarcopenia is a major public health problem. Depressive symptoms and dietary inflammatory potential play important roles in the development of sarcopenia. We aimed to disentangle the relationships between depressive symptoms, dietary inflammatory potential, and sarcopenia.MethodsA total of 6,082 participants from the National Health and Nutrition Examination Survey (NHANES) were included in the analyses. Sarcopenia was defined according to the Foundation for the National Institutes for Health (FNIH) criteria. The Depressive symptoms were assessed using the nine-item Patient Health Questionnaire (PHQ-9). Dietary Inflammatory Index (DII) was calculated based on 24-h dietary recall interview. Two sets of mediation models were constructed separately.ResultsDepressive symptoms and DII were associated with sarcopenia, with odds ratios [ORs] (95% CIs) 2.54 (1.27, 5.13) and 1.17 (1.00, 1.37), respectively. DII score mediated the association of depressive symptoms with low muscle mass, explaining a total of 10.53% of the association (indirect effect = 0.004). Depressive symptoms had a significant mediating effects on the association between DII with low muscle mass, explaining a total of 12.50% of the association (indirect effect = 0.001).ConclusionsOur findings suggested that both depressive symptoms and dietary inflammatory potential had direct effects, and indirect effects on low muscle mass, handgrip strength, muscle mass, through each other. It provides important insights into integrated nutritional and psychological intervention strategies in preventing sarcopenia.

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“…This association persisted even after adjusting for several confounders including the level of physical activity, particularly in older people ( Volaklis et al, 2019 ). A longitudinal cohort study identified the bidirectional associations between handgrip strength and depressive symptoms in Chinese adults ( Lian et al, 2021 ). Low handgrip strength has also been found to be associated with poor mental health among Korean males ( Hwang, Ahn & Choi, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Correlations between muscle strength and psychological health in Chinese adolescents: a cross-sectional analysis

Sun

Liu

et al. 2022

PeerJ

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Background Studies indicate that muscle strength is associated with good mental health. However, it remains unclear whether muscle strength is directly correlated with psychological symptoms in Chinese adolescents. Given the declining muscle strength and worrying mental health status of Chinese adolescents, the present study aimed to estimate the correlation between muscle strength and psychological symptoms as well as explore the gender differences in those correlations in Chinese adolescents. Method From April to July 2018, a total of 14,344 Chinese adolescents from eight provinces were selected using a stratified clustered sampling method. Psychological symptoms were evaluated using the Multidimensional Sub-health Questionnaire of Adolescents (MSQA), a verified and validated questionnaire that assesses three psychological areas: emotional symptoms, behavioral symptoms, and social adaptation difficulties. Muscle strength was assessed using grip strength, sit-ups, and standing long jump. The Chi-square test was used to compare the detection rates of the different categories of psychological symptoms. A logistic regression analysis was used to analyze the correlations between muscle strength and psychological symptoms and explore the gender differences in those correlations in Chinese adolescents. Results In general, the detection rate of psychological symptoms for Chinese adolescents was 21.39%. Males had a higher detection rate of psychological symptoms (22.12%) than females (20.66%, p < 0.05). Psychological symptoms were present in significantly fewer Chinese adolescents with a muscle strength index >P75 (19.26%) than among Chinese adolescents with a muscle strength index ≤P25 (23.00%) (χ2 = 23.417, p < 0.01). Compared with females, the OR values for males in most groups were over one (OR = 1.04–1.43), indicating that males have a higher risk of psychological symptoms than females. Conclusions The psychological symptom detection rate of Chinese adolescents is correlated with muscle strength. Psychological symptoms were more correlated to muscle strength in males than in females. The significance of the present study lies in the important insights for integrated mental and physical fitness intervention strategies that promote muscle strength and psychological symptoms simultaneously.

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Bidirectional Associations between Handgrip Strength and Depressive Symptoms: A Longitudinal Cohort Study

Cited by 17 publications

References 45 publications

Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study

Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study

Relationships Between Depressive Symptoms, Dietary Inflammatory Potential, and Sarcopenia: Mediation Analyses

Correlations between muscle strength and psychological health in Chinese adolescents: a cross-sectional analysis

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