Bidirectional association between functional disability and multimorbidity among middle-aged and older adults in Thailand

Pengpid, Supa; Peltzer, Karl; Anantanasuwong, Dararatt

doi:10.3389/fpubh.2022.1055699

Cited by 6 publications

(6 citation statements)

References 51 publications

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“…With regard to physical function, we found that multimorbidity was significantly associated with an increased risk of disability, which was consistent with previous research studies ( Quiñones et al, 2016 , 2018 ; Wei et al, 2018 ; Pengpid et al, 2022 ). We also found that the “cardio-metabolic” and “multisystem morbidity” classes were associated with a higher risk of disability, which is consistent with previous studies showing a positive association of metabolic multimorbidity with a higher risk of disability ( Zhao et al, 2021 ).…”

Section: Discussionsupporting

confidence: 92%

The effect of multimorbidity patterns on physical and cognitive function in diabetes patients: a longitudinal cohort of middle-aged and older adults in China

Zhou,

Qin,

et al. 2024

Front. Aging Neurosci.

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BackgroundThe prevalence of diabetes has increased rapidly, and comorbid chronic conditions are common among diabetes patients. However, little is known about the pattern of multimorbidity in diabetes patients and the effect on physical and cognitive function. This study aimed to assess the disease clusters and patterns of multimorbidity in diabetes patients using a novel latent class analysis (LCA) approach in middle-aged and older adults and explore the association between different clusters of multimorbidity in diabetes and the effect on physical and cognitive function.MethodsThis national observational study included 1,985 diabetes patients from the four waves of the China Health and Retirement Longitudinal Study (CHARLS) in 2011 to 2018. Thirteen chronic diseases were used in latent class analysis to identify the patterns of multimorbidity in diabetes, which span the cardiovascular, physical, psychological, and metabolic systems. Cognitive function is assessed via a structured questionnaire in three domains: memory, executive function, and orientation. We combined activities of daily living (ADL) with instrumental activities of daily living (IADL) to measure physical function. Linear mixed models and negative binomial regression models were used to analyze the association between patterns of multimorbidity in diabetes and the effect on cognitive function and disability, respectively.ResultsA sample of 1,985 diabetic patients was identified, of which 1,889 (95.2%) had multimorbidity; their average age was 60.6 years (standard deviation (SD) = 9.5), and 53.1% were women. Three clusters were identified: “cardio-metabolic” (n = 972, 51.5%), “mental-dyslipidemia-arthritis” (n = 584, 30.9%), and “multisystem morbidity” (n = 333, 17.6%). Compared with diabetes alone, the “multisystem morbidity” class had an increased association with global cognitive decline. All patterns of multimorbidity were associated with an increased risk of memory decline and disability; however, the “multisystem morbidity” group also had the strongest association and presented a higher ADL-IADL disability (ratio = 4.22, 95% CI = 2.52, 7.08) and decline in memory Z scores (β = −0.322, 95% CI = −0.550, −0.095, p = 0.0058).ConclusionSignificant longitudinal associations between different patterns of multimorbidity in diabetes patients and memory decline and disability were observed in this study. Future studies are needed to understand the underlying mechanisms and common risk factors for multimorbidity in diabetes patients and to propose treatments that are more effective.

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Section: Discussionsupporting

confidence: 92%

The effect of multimorbidity patterns on physical and cognitive function in diabetes patients: a longitudinal cohort of middle-aged and older adults in China

Zhou,

Qin,

et al. 2024

Front. Aging Neurosci.

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“…Although previous research used different classifications for the Barthel Index, for the current study, any participant with a score less than 100 was considered as having disability as this approach has been used in prior research using disability scales on community-dwelling older adults. [36][37][38][39] In the current study, we found that individuals with MLTC (those with ≥2 chronic diseases) are 2.5 times more likely to fall than those without a chronic disease. This is consistent with earlier reports by Yan et al 45 and You et al 46 Yan et al reported that patients with two, and ≥3 chronic diseases had an 85%, and 175% increased risk of falls, respectively, compared with older adults without chronic conditions.…”

Section: Discussionsupporting

confidence: 48%

“…This approach has been used in prior research using disability scales on community-dwelling older adults. [36][37][38][39] The validity and reliability of the BI was established for geriatric populations 40 and languages. [41][42][43] At the time of the study, no Arabic version of the BI was available.…”

Section: Falls Efficacy Scale International (Fes-i)mentioning

confidence: 99%

Multiple Long-Term Conditions and Disability are Independently Associated with Higher Risk of Fall Among Community Adults: a Cross-Sectional Study

Alenazi,

Alhwoaimel,

Alqahtani

et al. 2024

RMHP

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Background: Previous studies have suggested an association between falls and the presence of Multiple Long-Term Conditions (MLTC) or disabilities. However, there is limited understanding of how these factors independently or collectively contribute to the risk of falls and fear of falling among community-dwelling adults.Objective: This study examined the independent association between MLTC and the presence of disability with the risk of falls among community adults. Methods: A cross-sectional study included 324 adults (age ≥ 50). Demographic and clinical data included age, sex, body mass index (BMI), MLTC (≥ two chronic diseases) risk of fall (ie, history of fall in the previous 12-months, number of falls, and recurrent falls). The Barthel Index and Falls Efficacy Scale-International (FES-I) were used to assess disability and fear of fall, respectively. Results: MLTC (Odds Ratio (OR) 2.50, 95% Confidence Interval (CI) [1.26, 4.95], p=0.009), and disability (OR 1.71, 95% CI [1.04, 2.79], p = 0.034) were independently associated with history of falls. MLTC (Incidence Rate Ratio (IRR) 2.87, 95% CI [1.93, 4.29], p < 0.001) and disability (IRR 1.86 95% CI [1.46, 2.36], p < 0.001) were independently associated with an increased number of falls. MLTC (OR 4.50, 95% CI [1.78, 11.36], p = 0.001) and disability (OR 2.82, 95% CI [1.58,5.05], p < 0.001) were independently associated with recurrent falls. MLTC (B = 6.45, p < 0.001) and disability (B = 3.05, p = 0.025) were independently associated with increased fear of falling. Conclusion: This study indicated that both MLTC and disability are independently associated with falls, number of falls and fear of falling in this population.

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“…Chronic conditions were assessed by (self-reported) healthcare provider diagnosis: ‘(1) hypertension, (2) diabetes, (3) cardiovascular diseases, heart disease and heart failure, (4) rheumatism, arthritis, bone diseases and osteoporosis, (5) kidney diseases, (6) brain diseases and psychiatric problems and (7) lung diseases/emphysema’. 31 …”

Section: Methodsmentioning

confidence: 99%

Predictors of and healthcare utilisation of depressive symptoms among middle-aged and older adults in Thailand: a national cross-sectional community-based study in 2015

Kengganpanich,

Pengpid,

Peltzer

2023

BMJ Open

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ObjectiveThe prevalence of depressive symptoms and healthcare utilisation among the ageing population in Thailand is unclear. The study assessed the predictors of and healthcare utilisation of depressive symptoms among an ageing population in Thailand.DesignCross-sectional, population-based study.SettingNational sample of people aged 45 years and older in Thailand from the 2015 Health, Ageing and Retirement in Thailand (HART) study.ParticipantsThe sample included 5135 individuals (≥45 years) with complete depressive symptoms data from the 2015 HART study.Outcome measuresDepressive symptoms were measured with the Centre for Epidemiological Studies Depression Scale. Logistic regression was used to estimate the associations between sociodemographic factors, health factors and depressive symptoms, and the associations between depressive symptoms and different types of healthcare utilisation.ResultsThe study population included 5135 participants with a median age of 66 years. The prevalence of depressive symptoms was 13.9%. The proportion of past 2 year hospital admission was 12.8%, hospital outpatient 49.7%, health centre outpatient 26.2%, private clinic 8.4%, traditional medical practitioner 2.8%, medical home visit 4.9% and past-year medical check-up 50.3%. In adjusted logistic regression analysis, low income, residing in the Southern region, history of a cardiovascular disease, brain diseases and/or psychiatric problems and functional disability were positively associated with depressive symptoms. Male sex, being a Buddhist, urban residence, high religious involvement, moderate and high physical activity were negatively associated with depressive symptoms. In fully adjusted logistic regression models, depressive symptoms were positively associated with hospital inpatient utilisation, hospital outpatient utilisation, health centre utilisation and utilisation of a traditional medicine practitioner.ConclusionsMore than one in 10 participants had depressive symptoms. Chronic conditions, sociodemographic factors, physical inactivity and low religious involvement increased the odds of depressive symptoms. Furthermore, depressive symptoms increased the odds of conventional and traditional healthcare utilisation.

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Bidirectional association between functional disability and multimorbidity among middle-aged and older adults in Thailand

Cited by 6 publications

References 51 publications

The effect of multimorbidity patterns on physical and cognitive function in diabetes patients: a longitudinal cohort of middle-aged and older adults in China

The effect of multimorbidity patterns on physical and cognitive function in diabetes patients: a longitudinal cohort of middle-aged and older adults in China

Multiple Long-Term Conditions and Disability are Independently Associated with Higher Risk of Fall Among Community Adults: a Cross-Sectional Study

Predictors of and healthcare utilisation of depressive symptoms among middle-aged and older adults in Thailand: a national cross-sectional community-based study in 2015

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