2020
DOI: 10.1038/s41598-020-71834-w
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Bidirectional alterations in antibiotics susceptibility in Staphylococcus aureus—Pseudomonas aeruginosa dual-species biofilm

Abstract: In mixed infections, the bacterial susceptibility differs significantly compared to monocultures of bacteria, and generally the concentrations of antibiotics required for the treatment increases drastically. For S. aureus and P. aeruginosa dual species biofilms, it has been numerously reported that P. aeruginosa decreases S. aureus susceptibility to a broad range of antibiotics, including beta-lactams, glycopeptides, aminoglycosides, macrolides, while sensitizes to quinolones via secretion of various metabolit… Show more

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Cited by 53 publications
(45 citation statements)
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“…These changes to the environment alter how bacteria may interact with one another. This is highlighted by Trizna et al (2020) where polymicrobial biofilms of P. aeruginosa and S. aureus without treatment revealed that P. aeruginosa dominated the lower layers within the biofilm whereas S. aureus was found within microcolonies in the upper layers. Upon treatment with vancomycin, however, the spatial organization of the biofilm changed and S. aureus was found within the middle-lower layers.…”
Section: Hos T Environment Lo C Aliz Ati On and Motilit Y During P Aerug Inosa S Aureus Coinfec Ti On Smentioning
confidence: 99%
“…These changes to the environment alter how bacteria may interact with one another. This is highlighted by Trizna et al (2020) where polymicrobial biofilms of P. aeruginosa and S. aureus without treatment revealed that P. aeruginosa dominated the lower layers within the biofilm whereas S. aureus was found within microcolonies in the upper layers. Upon treatment with vancomycin, however, the spatial organization of the biofilm changed and S. aureus was found within the middle-lower layers.…”
Section: Hos T Environment Lo C Aliz Ati On and Motilit Y During P Aerug Inosa S Aureus Coinfec Ti On Smentioning
confidence: 99%
“…In this regard, mixed biofilms with C. albicans have been shown to confer S. epidermidis and S. aureus cells a specific and enhanced tolerance toward vancomycin and other antimicrobials, linked to the protective effect provided by the fungal ECM and modulation of the drug metabolism in bacterial cells [ 38 , 111 , 112 , 113 ]. Similarly, in mixed biofilms, S. aureus and P. aeruginosa have been shown to bidirectionally alter their respective antimicrobial susceptibility patterns [ 114 , 115 , 116 ].…”
Section: Hurdles In Tackling Staphylococcal Biofilmsmentioning
confidence: 99%
“…Some studies have found P. aeruginosa to suppress S. aureus biofilm formation [159], while others have found compounds produced by P. aeruginosa to increase S. aureus biofilm formation [160,161]. S. aureus completely avoided vancomycin, ampicillin, and ceftriaxone by 'hiding' in P. aeruginosa biofilms; however, the mixed biofilms were found to be more susceptible to the broad-spectrum antibiotics ciprofloxacin and aminoglycosides [162] (Figure 1). Many of these studies have focused on interactions between reference strains, with PA01 or PA14 commonly outcompeting S. aureus isolates.…”
Section: Impacts On Antibacterial Resistancementioning
confidence: 99%
“…The staphylococcal protein A (SpA) produced by S. aureus has been shown to bind to the P. aeruginosa EPS, Psl, modifying biofilm architecture and increasing resistance of P. aeruginosa to inhaled tobramycin [28]. Another recent study has shown bi-directional changes in resistance of both P. aeruginosa and S. aureus in mixed biofilms [162]. P. aeruginosa evolved for 150 generations in the presence of S. aureus and became more resistant to ß-lactam antibiotics but not ciprofloxacin or polymyxin due to a loss of a glycosyltransferase, wbpL PA14 , involved in the biosynthesis of polysaccharide antigen and the O-specific antigen (OSA).…”
Section: Impacts On Antibacterial Resistancementioning
confidence: 99%